<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">systhiper</journal-id><journal-title-group><journal-title xml:lang="ru">Системные гипертензии</journal-title><trans-title-group xml:lang="en"><trans-title>Systemic Hypertension</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2075-082X</issn><issn pub-type="epub">2542-2189</issn><publisher><publisher-name>LLC «ИнтерМедсервис»</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">systhiper-168</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>СТАТЬИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ARTICLES</subject></subj-group></article-categories><title-group><article-title>Метаболические и антиоксидантные эффекты небиволола при лечении больных артериальной гипертензией</article-title><trans-title-group xml:lang="en"><trans-title></trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Напалков</surname><given-names>Д. А.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Головенко</surname><given-names>Е. Н.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff xml:lang="ru" id="aff-1"><institution>Московская медицинская академия имени И.М.Сеченова</institution><country>Russian Federation</country></aff><pub-date pub-type="collection"><year>2008</year></pub-date><pub-date pub-type="epub"><day>23</day><month>12</month><year>2022</year></pub-date><volume>5</volume><issue>4</issue><fpage>40</fpage><lpage>42</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Напалков Д.А., Головенко Е.Н., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Напалков Д.А., Головенко Е.Н.</copyright-holder><copyright-holder xml:lang="en">Напалков Д.А., Головенко Е.Н.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.syst-hypertension.ru/jour/article/view/168">https://www.syst-hypertension.ru/jour/article/view/168</self-uri></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Schmidt АС, Graf С, Brixius K, Scholze1 J. Blood pressure-lowering effect of nebivolol in hypertensive patients with type 2 diabetes mellitus. The YESTONO Study. Clin Drug Investigat 2007; 27 (12): 841-9.</mixed-citation><mixed-citation xml:lang="en">Schmidt АС, Graf С, Brixius K, Scholze1 J. Blood pressure-lowering effect of nebivolol in hypertensive patients with type 2 diabetes mellitus. The YESTONO Study. Clin Drug Investigat 2007; 27 (12): 841-9.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Lithel HO. Effect of antihypertensive drugs on insulin, glucose and lipid metabolism. Diabet Care 1991; 14: 203-9.</mixed-citation><mixed-citation xml:lang="en">Lithel HO. Effect of antihypertensive drugs on insulin, glucose and lipid metabolism. Diabet Care 1991; 14: 203-9.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Ignarro L, Zanchetti A, Vintila MM, Redon J. Cardiovascular risk management: the role of nebivolol. June 2008 Supplement of Practicing Medicine. Information and Management Journal.</mixed-citation><mixed-citation xml:lang="en">Ignarro L, Zanchetti A, Vintila MM, Redon J. Cardiovascular risk management: the role of nebivolol. June 2008 Supplement of Practicing Medicine. Information and Management Journal.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Kuroedov A, Cosentino F, Lusher TF. Pharmacological mechanisms of clinically favorable properties of a selective b1-adrenoreceptor antagonist, nibivolol. Cardiovasc Drug Rev 2004; 22 (3): 155-68.</mixed-citation><mixed-citation xml:lang="en">Kuroedov A, Cosentino F, Lusher TF. Pharmacological mechanisms of clinically favorable properties of a selective b1-adrenoreceptor antagonist, nibivolol. Cardiovasc Drug Rev 2004; 22 (3): 155-68.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Cockeroft JR, Chowienezyk PJ, Brett SE et al. Nebivolol vasodilates human forearm vasculature: evidence for an L-arginin/NO-dependent mechanism. J Pharmacol Exp Ther 1995; 274: 1067-71.</mixed-citation><mixed-citation xml:lang="en">Cockeroft JR, Chowienezyk PJ, Brett SE et al. Nebivolol vasodilates human forearm vasculature: evidence for an L-arginin/NO-dependent mechanism. J Pharmacol Exp Ther 1995; 274: 1067-71.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Pessina AC. Metabolic effects and safety profile of nebivolol. J Cardiovasc Pharmacol 2001; 38 (Suppl. 3): 33-5.</mixed-citation><mixed-citation xml:lang="en">Pessina AC. Metabolic effects and safety profile of nebivolol. J Cardiovasc Pharmacol 2001; 38 (Suppl. 3): 33-5.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Peter P, Martin U, Sharma A et al. Effect of treatment with nebivolol on parameters of oxidative stress in type 2 diabetics with mild to moderate hypertension. J Clin Pharm Ther 2006; 31: 153-9.</mixed-citation><mixed-citation xml:lang="en">Peter P, Martin U, Sharma A et al. Effect of treatment with nebivolol on parameters of oxidative stress in type 2 diabetics with mild to moderate hypertension. J Clin Pharm Ther 2006; 31: 153-9.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Poirier L, Cleroux J, Nadeau A et al. Effects of nebivolol and atenolol on insulin sensitivity and haemodynamics in hypertensive patients. J Hypertens 2001; 19: 1429-35.</mixed-citation><mixed-citation xml:lang="en">Poirier L, Cleroux J, Nadeau A et al. Effects of nebivolol and atenolol on insulin sensitivity and haemodynamics in hypertensive patients. J Hypertens 2001; 19: 1429-35.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Tzemos N, Lim PO, MacDonald TM. Nebivolol reverses endothelial dysfunction in essential hypertension. Circulation 2001; 104: 511-4.</mixed-citation><mixed-citation xml:lang="en">Tzemos N, Lim PO, MacDonald TM. Nebivolol reverses endothelial dysfunction in essential hypertension. Circulation 2001; 104: 511-4.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Pasini AF, Garbin U, Nava MC et al. Nebivolol decreases oxidative stress in essential hypertensive patients and increases nitric oxide by reducing its oxidative inactivation. J Hypertens 2005; 23: 589-96.</mixed-citation><mixed-citation xml:lang="en">Pasini AF, Garbin U, Nava MC et al. Nebivolol decreases oxidative stress in essential hypertensive patients and increases nitric oxide by reducing its oxidative inactivation. J Hypertens 2005; 23: 589-96.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Falciani M, Rinaldi B, D'Agostino B et al. Effects of nebivolol on human platelet aggregation. J Cardiovasc Pharmacol 2001; 38: 922-9.</mixed-citation><mixed-citation xml:lang="en">Falciani M, Rinaldi B, D'Agostino B et al. Effects of nebivolol on human platelet aggregation. J Cardiovasc Pharmacol 2001; 38: 922-9.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Brehm BR, Wolf SC, Bertsch D et al. Effects of nebivolol on proliferation and apoptosis of human coronary artery smooth muscle and endothelial cells. Cardiovasc Res 2001; 49: 430-9.</mixed-citation><mixed-citation xml:lang="en">Brehm BR, Wolf SC, Bertsch D et al. Effects of nebivolol on proliferation and apoptosis of human coronary artery smooth muscle and endothelial cells. Cardiovasc Res 2001; 49: 430-9.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Ambrosioni E, Borghi C. Tolerability of nebivolol in head-to-head clinical trials versus other cardioselective b-blockers in treatment of hypertension. A meta-analysis. High Blood Press Cardiovasc Prev 2005; 12 (1): 27-35.</mixed-citation><mixed-citation xml:lang="en">Ambrosioni E, Borghi C. Tolerability of nebivolol in head-to-head clinical trials versus other cardioselective b-blockers in treatment of hypertension. A meta-analysis. High Blood Press Cardiovasc Prev 2005; 12 (1): 27-35.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Predel HG, Mainka W, Schillings W et al. Integrated effects of the vasodilating beta-blocker nebivolol on exercise performance, energy metabolism, cardiovascular and neurohormonal parameters in physically active patients with arterial hypertension. J Hum Hypertens 2001; 15 (10): 715-21.</mixed-citation><mixed-citation xml:lang="en">Predel HG, Mainka W, Schillings W et al. Integrated effects of the vasodilating beta-blocker nebivolol on exercise performance, energy metabolism, cardiovascular and neurohormonal parameters in physically active patients with arterial hypertension. J Hum Hypertens 2001; 15 (10): 715-21.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Flather MD, Shibata MC, Coats AJ et al. Randomized trial to determine the effect of nebivolol on mortality and cardiovascular hospital admission in elderly patients with heart failure (SENIORS). Eur Heart J 2005; 26 (3): 215-25.</mixed-citation><mixed-citation xml:lang="en">Flather MD, Shibata MC, Coats AJ et al. Randomized trial to determine the effect of nebivolol on mortality and cardiovascular hospital admission in elderly patients with heart failure (SENIORS). Eur Heart J 2005; 26 (3): 215-25.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">SENIORS, data on file. In: The Proceedings of the World Congress of Cardiology; 2006 Sept. 2-6, Barcelona.</mixed-citation><mixed-citation xml:lang="en">SENIORS, data on file. In: The Proceedings of the World Congress of Cardiology; 2006 Sept. 2-6, Barcelona.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Celik T, Iyisoy A, Kursaklioglu H et al. Comparative effects of nebivolol and metoprolol on oxidative stress, insulin resistance, plasma adiponectin and soluble P-selectin levels in hypertensive patients. J Hypertens 2006; 24 (3): 591-6.</mixed-citation><mixed-citation xml:lang="en">Celik T, Iyisoy A, Kursaklioglu H et al. Comparative effects of nebivolol and metoprolol on oxidative stress, insulin resistance, plasma adiponectin and soluble P-selectin levels in hypertensive patients. J Hypertens 2006; 24 (3): 591-6.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Agabiti Rosei E, Rizzoni D. Metabolic profile of nebivolol, a b-adrenoceptor antagonist with unique characteristics. Drugs 2007; 67 (8): 1097-107.</mixed-citation><mixed-citation xml:lang="en">Agabiti Rosei E, Rizzoni D. Metabolic profile of nebivolol, a b-adrenoceptor antagonist with unique characteristics. Drugs 2007; 67 (8): 1097-107.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Дедов И.И., Бондаренко И.З., Соляник Ю.А. и др. Метаболические эффекты небиволола у больных сахарным диабетом 2 типа. Кардиология. 2001; 5 (41): 35-7.</mixed-citation><mixed-citation xml:lang="en">Дедов И.И., Бондаренко И.З., Соляник Ю.А. и др. Метаболические эффекты небиволола у больных сахарным диабетом 2 типа. Кардиология. 2001; 5 (41): 35-7.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Fogari R, Zoppi A, Lazzari P et al. Comparative effects of nebivolol and atenolol on blood pressure and insulin sensitivity in hypertensive subjects with type II diabetes. J Hum Hypertens 1997; 11: 753-7.</mixed-citation><mixed-citation xml:lang="en">Fogari R, Zoppi A, Lazzari P et al. Comparative effects of nebivolol and atenolol on blood pressure and insulin sensitivity in hypertensive subjects with type II diabetes. J Hum Hypertens 1997; 11: 753-7.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Маколкин В.И., Ахмедова О.О., Бувальцев В.И. и др. Клинические и метаболические эффекты кардиоселективных b-адреноблокаторов небиволола и метопролола у пациентов с гипертонией и ишемической болезнью сердца в сочетании с сахарным диабетом 2 типа. Кардиология. 2003; 43 (2): 40-3.</mixed-citation><mixed-citation xml:lang="en">Маколкин В.И., Ахмедова О.О., Бувальцев В.И. и др. Клинические и метаболические эффекты кардиоселективных b-адреноблокаторов небиволола и метопролола у пациентов с гипертонией и ишемической болезнью сердца в сочетании с сахарным диабетом 2 типа. Кардиология. 2003; 43 (2): 40-3.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Rizos E, Bairaktari E, Kostoula A et al. The combination of nebivolol plus pravastatin is associated with a more beneficial metabolic profile compared to that of atenolol plus pravastatin in hypertensive patients with dyslipidemia: a pilot study. J Cardiovasc Pharmacol Ther 2003; 8 (2): 127-34.</mixed-citation><mixed-citation xml:lang="en">Rizos E, Bairaktari E, Kostoula A et al. The combination of nebivolol plus pravastatin is associated with a more beneficial metabolic profile compared to that of atenolol plus pravastatin in hypertensive patients with dyslipidemia: a pilot study. J Cardiovasc Pharmacol Ther 2003; 8 (2): 127-34.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Lacourciere Y, Poirier L, Lefebvre J et al. Comparative effects of a new cardioselective beta-blocker nebivolol and nifedipine sustained-release on 24-hour ambulatory blood pressure and plasma lipoproteins. J Clin Pharmacol 1992; 32 (7): 660-6.</mixed-citation><mixed-citation xml:lang="en">Lacourciere Y, Poirier L, Lefebvre J et al. Comparative effects of a new cardioselective beta-blocker nebivolol and nifedipine sustained-release on 24-hour ambulatory blood pressure and plasma lipoproteins. J Clin Pharmacol 1992; 32 (7): 660-6.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Lacourciere Y, Arnott W. Placebo-controlled comparison of the effects of nebivolol and low-dose hydrochlorothiazide as monotherapies and in combination on blood pressure and lipid profile in hypertensive patients. J Hum Hypertens 1994; 8 (4): 283-8.</mixed-citation><mixed-citation xml:lang="en">Lacourciere Y, Arnott W. Placebo-controlled comparison of the effects of nebivolol and low-dose hydrochlorothiazide as monotherapies and in combination on blood pressure and lipid profile in hypertensive patients. J Hum Hypertens 1994; 8 (4): 283-8.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Kaiser T, Heise T, Nosek L et al. Influence of nebivolol and enalapril on metabolic parameters and arterial stiffness in hypertensive type 2 diabetic patients. J Hypertens 2006; 24: 1397-403.</mixed-citation><mixed-citation xml:lang="en">Kaiser T, Heise T, Nosek L et al. Influence of nebivolol and enalapril on metabolic parameters and arterial stiffness in hypertensive type 2 diabetic patients. J Hypertens 2006; 24: 1397-403.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
