systhiperСистемные гипертензииSystemic Hypertension2075-082X2542-2189LLC «ИнтерМедсервис»systhiper-206Research ArticleСТАТЬИARTICLESАнтагонисты рецептора ангиотензина II в нефропротекции при сахарном диабете типа 2: фокус на лозартанAngiotensin receptor blockers in nephroprotection at patients with diabetes mellitus: focus on losartanВикуловаО. К.noemail@neicon.ruШестаковаМ. В.noemail@neicon.ruФГУ Эндокринологический научный центр МЗСР, МоскваRussian Federation200923122022633337Copyright © Викулова О.К., Шестакова М.В., 20222022Викулова О.К., Шестакова М.В.Викулова О.К., Шестакова М.В.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.syst-hypertension.ru/jour/article/view/206

Целый ряд крупных исследований убедительно доказали связь между повышенным АД и риском возникновения сердечно-сосу- дистых осложнений (ССО), таких как мозговой инсульт, инфаркт миокарда, сердечная недостаточность. Но ни одно исследова- ние в сравнении с активным препаратом не доказало превосходства одного лекарственного средства над другим в отношении снижения риска ССО и смертности. В обзоре представлены данные об эффективности терапии рамиприлом в свете доказатель- ной медицины, которые наглядно демонстрируют, наряду с хорошими антигипертензивными свойствами, эффективность в от- ношении возникновения новых случаев сахарного диабета и его осложнений. Высокая эффективность лозартана сочетается с низкой частотой развития побочных эффектов.

Many large studies have provided strong evidence that there is an association of elevated BP with a risk for cardiovascular events (CVE), such as stroke, myocardial infarction and heart failure. But none of the studies has indicated that a drug is more effective than another one in reducing the risk for CVE and death. The article summarizes the available data on ramipril in hypertensive patients of high cardiovascular risk. The results of studies demonstrate strong and long-lasting antihypertensive effect of losartan. Moreover, losartan treatment decreases cardiovascular events rate, damage of target organs, atherosclerosis progression and new cases of diabetes mellitus. Losartan shows both high efficacy and low adverse event rate.

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The authors declare that there are no conflicts of interest present.