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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">systhiper</journal-id><journal-title-group><journal-title xml:lang="ru">Системные гипертензии</journal-title><trans-title-group xml:lang="en"><trans-title>Systemic Hypertension</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2075-082X</issn><issn pub-type="epub">2542-2189</issn><publisher><publisher-name>LLC «ИнтерМедсервис»</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">systhiper-26</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КАРДИОЛОГИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CARDIOLOGY</subject></subj-group></article-categories><title-group><article-title>Что лежит в основе эффективности лечения периндоприлом больных ишемической болезнью сердца – небольшое снижение артериального давления или нечто большее? Итоги и перспективы исследования EUROPA</article-title><trans-title-group xml:lang="en"><trans-title></trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Хирманов</surname><given-names>В. Н.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff xml:lang="ru" id="aff-1"><institution>Санкт-Петербургская государственная медицинская академия им. И.И.Мечникова</institution><country>Russian Federation</country></aff><pub-date pub-type="collection"><year>2004</year></pub-date><pub-date pub-type="epub"><day>23</day><month>12</month><year>2022</year></pub-date><issue>1</issue><fpage>34</fpage><lpage>37</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Хирманов В.Н., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Хирманов В.Н.</copyright-holder><copyright-holder xml:lang="en">Хирманов В.Н.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.syst-hypertension.ru/jour/article/view/26">https://www.syst-hypertension.ru/jour/article/view/26</self-uri><abstract><p>Завершено рандомизированное двойное слепое плацебо-контролируемое, многоцентровое исследование EUROPA (European trial on Reduction Of cardiac events with Perindopril in stable coronary Artery disease). Его результаты опубликованы в журнале Lancet (N 9386 за 2003 г.) [<xref ref-type="bibr" rid="cit1">1</xref>] и впервые обсуждены на съезде Европейского общества кардиологов в сентябре прошедшего года. Это новое крупное международное исследование имеет большое значение для развития многих аспектов клинической и теоретической кардиологии. Один из них – причина достоверных преимуществ нового подхода к лечению больных ишемической болезнью сердца – представляется актуальным для обсуждения. Но прежде необходимо кратко сформулировать основные положения исследования EUROPA. Цель исследования. Как это следует из названия проекта, цель состояла в решении вопроса о том, эффективно ли применение ингибитора ангиотензинпревращающего фермента (ИАПФ) периндоприла (хорошо известного отечественным врачам под названием "Престариум") для лечения больных со стабильным течением ишемической болезни сердца (ИБС), не осложненной сердечной недостаточностью.</p></abstract></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Fox K.M. EURopean trial On reduction of cardiac events with Perindopril in stable coronary Artery disease Investigators/Efficacy of perindopril in reduction of cardiovascular events among patients with stable coronary artery disease: randomised, double - blind, placebo - controlled, multicentre trial (the EUROPA study). Lancet 2003; 362 (9386): 782–8.</mixed-citation><mixed-citation xml:lang="en">Fox K.M. 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