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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">systhiper</journal-id><journal-title-group><journal-title xml:lang="ru">Системные гипертензии</journal-title><trans-title-group xml:lang="en"><trans-title>Systemic Hypertension</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2075-082X</issn><issn pub-type="epub">2542-2189</issn><publisher><publisher-name>LLC «ИнтерМедсервис»</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">systhiper-276</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>СТАТЬИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ARTICLES</subject></subj-group></article-categories><title-group><article-title>«Ингибиторы ангиотензинпревращающего фермента или сартаны у больных с высоким риском развития осложнений сердечно-сосудистых заболеваний» – неправильный вопрос или нежелательный ответ</article-title><trans-title-group xml:lang="en"><trans-title>Angiotensin-converting enzyme inhibitors or sartans in patients at high risk for cardiovascular events: a wrong question or an undesirable answer</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гиляревский</surname><given-names>С. Р.</given-names></name><name name-style="western" xml:lang="en"><surname>Gilyarevsky</surname><given-names>S. R.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Орлов</surname><given-names>В. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Orlov</surname><given-names>V. A.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кузьмина</surname><given-names>И. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Kuzmina</surname><given-names>I. M.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Голшмид</surname><given-names>М. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Golshmid</surname><given-names>M. V.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff xml:lang="ru" id="aff-1"><institution>ГБОУ ДПО Российская медицинская академия последипломного образования Минздрава РФ</institution><country>Russian Federation</country></aff><aff xml:lang="ru" id="aff-2"><institution>Московский городский научно-исследовательский институт скорой помощи им. Н.В.Склифосовского</institution><country>Russian Federation</country></aff><pub-date pub-type="collection"><year>2013</year></pub-date><pub-date pub-type="epub"><day>23</day><month>12</month><year>2022</year></pub-date><volume>10</volume><issue>1</issue><fpage>35</fpage><lpage>38</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Гиляревский С.Р., Орлов В.А., Кузьмина И.М., Голшмид М.В., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Гиляревский С.Р., Орлов В.А., Кузьмина И.М., Голшмид М.В.</copyright-holder><copyright-holder xml:lang="en">Gilyarevsky S.R., Orlov V.A., Kuzmina I.M., Golshmid M.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.syst-hypertension.ru/jour/article/view/276">https://www.syst-hypertension.ru/jour/article/view/276</self-uri><abstract><p>В статье обсуждаются современные представления о роли применения ингибиторов ангиотензинпревращающего фермента и блокаторов рецепторов ангиотензина II с целью профилактики развития тяжелых осложнений сердечно-сосудистых заболеваний. Приводятся как соответствующие доказательные данные, так и мнения экспертов. Рассматриваются возможные причины клинической инертности, обусловливающей отклонения в тактике применения средств, подавляющих активность ренин-ангиотензиновой системы.</p></abstract><trans-abstract xml:lang="en"><p>The paper discusses current views on the role of using angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers to prevent severe cardiovascular events. It gives both respective documentary information and experts’ opinions. The possible causes of clinical inertness defining deviations in the tactics of using drugs that suppress the activity of the renin-angiotensin system are considered.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>ингибиторы ангиотензинпревращающего фермента</kwd><kwd>блокаторы рецепторов ангиотензина II</kwd><kwd>клиническая инертность</kwd></kwd-group><kwd-group xml:lang="en"><kwd>angiotensin-converting enzyme inhibitors</kwd><kwd>angiotensin II receptor blockers</kwd><kwd>clinical inertness</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Heart Outcomes Prevention Evaluation Study Investigators. Effects of an angiotensin - converting - enzyme inhibitor, ramipril, on cardiovascular events in high risk patients. 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