systhiperСистемные гипертензииSystemic Hypertension2075-082X2542-2189LLC «ИнтерМедсервис»systhiper-278Research ArticleСТАТЬИARTICLESЛечение артериальной гипертензии: есть ли место для b-адреноблокаторов?Hypertension treatment: Is there a place for b-adrenoblockers?МинушкинаЛ. О.MinushkinaL. O.minushkina@mail.ruФГБУ Учебно-научный медицинский центр Управления делами Президента РФRussian Federation2013231220221014851Copyright © Минушкина Л.О., 20222022Минушкина Л.О.Minushkina L.O.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.syst-hypertension.ru/jour/article/view/278

Статья посвящена возможностям использования в терапии артериальной гипертензии (АГ) b-адреноблокаторов. Более подробно рассмотрены особенности небиволола, высокоселективного b-адреноблокатора III поколения, оказывающего влияние на функцию эндотелия и стимулирующего синтез NO. Описан возможный механизм ангиопротективного действия препарата. Приведены доказательства антигипертензивной эффективности. Рассмотрены вопросы влияния небиволола на состояние органов-мишеней при АГ, метаболические эффекты небиволола, возможности назначения препарата у больных с сопутствующими заболеваниями.

The paper considers whether b-adrenoblockers may be used in the therapy of hypertension. It views in more detail the specific features of nebivolol, a third-generation highly selective b-adrenoblocker that has properties of acting on endothelial function and stimulating NO synthesis. The possible mechanism for the angioprotective activity of the drug is described. There is evidence for its antihypertensive efficacy. The effect of nebivolol on target organs in hypertension, its metabolic effects, and the possibilities of using the drug in patients with comorbidities are considered.

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The authors declare that there are no conflicts of interest present.