systhiperСистемные гипертензииSystemic Hypertension2075-082X2542-2189LLC «ИнтерМедсервис»systhiper-280Research ArticleСТАТЬИARTICLESРеальные и потенциальные преимущества антагониста кальция III поколения лерканидипинаReal and potential benefits of third-generation calcium antagonistsКириченкоА. А.KirichenkoA. A.noemail@neicon.ruГБОУ ДПО Российская медицинская академия последипломного образованияRussian Federation2013231220221015761Copyright © Кириченко А.А., 20222022Кириченко А.А.Kirichenko A.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.syst-hypertension.ru/jour/article/view/280

Рассмотрены особенности фармакокинетики дигидропиридинов III поколения (фармакокинетика, контролируемая мембраной). Сравнительные исследования показали наряду с большой продолжительностью действия высокую эффективность, не уступающую действию основных групп антигипертензивных препаратов. Для лерканидипина доказано нефропротективное действие, сопоставимое с таковым ингибиторов ангиотензинпревращающего фермента. Показана лучшая переносимость и безопасность в сравнении с антагонистами кальция II поколения.

The paper considers the specific features of the pharmacokinetics of third-generation dihydropyridines (membrane-controlled pharmacokinetics). Comparative trials have shown their longer action and high efficacy, which are highly competitive with those of major groups of antihypertensive drugs. Lercanidipine proved to have the nephroprotective activity comparable with that of angiotensin-converting enzyme (ACE) inhibitors. They have been demonstrated to have a better tolerance and safety than second-generation calcium antagonists.

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The authors declare that there are no conflicts of interest present.