systhiperСистемные гипертензииSystemic Hypertension2075-082X2542-2189LLC «ИнтерМедсервис»systhiper-288Research ArticleКАРДИОЛОГИЯCARDIOLOGYТорасемид: дополнительные преимущества применения при артериальной гипертензии у женщин в постменопаузеTorasemide: additional benefits for postmenopausal women with arterial hypertensionТкачеваО. Н.TkachevaO. N.noemail@neicon.ruРунихинаН. К.RunikhinaN. K.noemail@neicon.ruШарашкинаН. В.SharashkinaN. V.noemail@neicon.ruФГБУ Государственный научно-исследовательский центр профилактической медицины Минздрава РФ, МоскваRussian FederationФГБУ Научный центр акушерства, гинекологии и перинатологии им. акад. В.И.Кулакова Минздрава РФ, МоскваRussian Federation201323122022102913Copyright © Ткачева О.Н., Рунихина Н.К., Шарашкина Н.В., 20222022Ткачева О.Н., Рунихина Н.К., Шарашкина Н.В.Tkacheva O.N., Runikhina N.K., Sharashkina N.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.syst-hypertension.ru/jour/article/view/288

Эффективный и безопасный петлевой диуретик торасемид в отличие от других петлевых диуретиков имеет дополнительные эффекты, связанные с одновременной блокадой ренин-ангиотензин-альдостероновой системы. Торасемид используется у больных артериальной гипертензией как в виде монотерапии, так и в комбинации с другими антигипертензивными средствами. В низких дозах торасемид оказывает длительное антигипертензивное действие, незначительно влияя на содержание калия в крови и показатели пуринового, углеводного и липидного метаболизма. Благодаря этому он может использоваться для длительного лечения артериальной гипертензии. Торасемид особенно эффективен у женщин в период постменопаузы, так как у этих женщин чаще формируется низкорениновая объемозависимая артериальная гипертензия. Таким образом, торасемид может быть использован для длительной антигипертензивной терапии у женщин в постменопаузе.

Effective and safe diuretic torasemide has additional effects of renin-angiotensin-aldosterone system blockage. Torasemide can be used as monotherapy or combined with other antihypertensives. In low doses torasemide produces pronounced antihypertensive effect without augmentation of excretion of potassium and water with urine. Long-term administration of torasemide was not associated with significant effects on lipid, purine, carbohydrate, or electrolyte metabolism parameters. Torasemide particularly effective in postmenopausal women, as these women are more likely formed low-renin hypertension. Therefore, torasemide can be used more widely in modern clinical practice.

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The authors declare that there are no conflicts of interest present.