systhiperСистемные гипертензииSystemic Hypertension2075-082X2542-2189LLC «ИнтерМедсервис»systhiper-289Research ArticleКАРДИОЛОГИЯCARDIOLOGYСартаны в лечении больных артериальной гипертензией высокого риска: возможности кандесартанаSartans in the treatment of high-risk hypertension: the abilities of candesartanМорозоваТ. Е.MorozovaT. E.temorozova@gmail.comГБОУ ВПО Первый МГМУ им. И.М.Сеченова Минздрава РФRussian Federation2013231220221021318Copyright © Морозова Т.Е., 20222022Морозова Т.Е.Morozova T.E.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.syst-hypertension.ru/jour/article/view/289

В работе представлен обзор литературы по вопросам лечения артериальной гипертензии препаратами, блокирующими активность ренин-ангиотензин-альдостероновой системы, – блокаторами рецепторов ангиотензина II, действие которых основано на торможении активности ренин-ангиотензин-альдостероновой системы на уровне рецепторов ангиотензина II. Блокатор ангиотензиновых рецепторов кандесартан (Атаканд®) наряду с выраженным долгосрочным антигипертензивным действием обладает органопротективными свойствами (вызывает обратное развитие гипертрофии левого желудочка, оказывает нефропротекцию), антидиабетогенным действием, предупреждает развитие мозгового инсульта. Опыт клинического применения кандесартана свидетельствует о высокой эффективности и хорошем спектре безопасности у разных категорий больных артериальной гипертензией, при сочетанной патологии, при хронической сердечной недостаточности, сахарном диабете, ожирении.

This paper presents an overview of the literature on the treatment of arterial hypertension drugs that block the renin-angiotensin-aldosterone system (RAAS) – angiotensin receptor blockers ΙΙ (ARB), whose action is based on inhibition of the RAAS at the AII receptor. ARB candesartan (atakand), along with a strong long-term antihypertensive effect has organoprotective (causes regression of LVH has nephroprotection) antidiabetogennym effect, prevents the development of stroke. Clinical experience suggests candesartan, high efficiency and a good range of security among different categories of hypertensive patients with concomitant pathology, chronic heart failure, diabetes, obesity.

артериальная гипертензияантигипертензивная терапияблокада ренин-ангиотензин-альдостероновой системыблокатор рецепторов ангиотензина IIорганопротекциягипертрофия миокарда левого желудочкакандесартанАтаканд®hypertensionhypertensionantihypertensive therapyblockade of the renin-angiotensin-aldosterone systemangiotensin receptor blocker IIorganoprotectiveregression of LVHcandesartanAtakand®ReferencesEzzati M, Lopez A, Rodgers A et al. Comparative Quantification of Health Risks: Global and Regional Burden of Disease Attributable to Selected Major Risk Factors. Geneva: World Health Organization, 2004.Ezzati M, Lopez A, Rodgers A et al. Comparative Quantification of Health Risks: Global and Regional Burden of Disease Attributable to Selected Major Risk Factors. Geneva: World Health Organization, 2004.Chobanian A.V. Shattuck Lecture. The hypertension paradox – more uncontrolled disease despite improved therapy. N Engl J Med 2009; 361: 878–87.Chobanian A.V. Shattuck Lecture. 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The authors declare that there are no conflicts of interest present.