systhiperСистемные гипертензииSystemic Hypertension2075-082X2542-2189LLC «ИнтерМедсервис»systhiper-293Research ArticleМЕТАБОЛИЧЕСКИЕ НАРУШЕНИЯMETABOLIC DISTURBANCESВозможности агониста имидазолиновых рецепторов моксонидина в лечении больных артериальной гипертонией с метаболическими нарушениями: окончательные результаты исследования MERSYUse of diuretics in hypertensive patients with metabolic disturbancesЖернаковаЮ. В.noemail@neicon.ruЧазоваИ. Е.noemail@neicon.ruИнститут клинической кардиологии им. А.Л.Мясникова ФГБУ РКНПК Минздрава РФ, МоскваRussian Federation2013231220221023440Copyright © Жернакова Ю.В., Чазова И.Е., 20222022Жернакова Ю.В., Чазова И.Е.Жернакова Ю.В., Чазова И.Е.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.syst-hypertension.ru/jour/article/view/293

Завершенное в 2008 г. многоцентровое исследование MERSY (Moxonidine Efficacy on blood pressure Reduction revealed in a metabolic SYndrome population) было посвящено оценке долгосрочной безопасности и эффективности агониста имидазолиновых рецепторов типа I2 – моксонидина (у пациентов с артериальной гипертонией и метаболическим синдромом в общей группе и заранее определенной подгруппе пациенток в постменопаузе). В 2013 г. были опубликованы окончательные международные результаты исследования MERSY, которые показали высокую антигипертензивную активность моксонидина, а также его позитивное влияние на метаболические параметры и массу тела.

The multicenter research MERSY (Moxonidine Efficacy on blood pressure Reduction revealed in a metabolic SYndrome population) finished in 2008 was devoted to an assessment of long-term safety and efficiency of agonist I2-imidazolin receptors – moxonidine in patients with arterial hypertension and metabolic syndrome (in the general group and in advance defined subgroup of patients in a postmenopause). In 2013 final international results of the research MERSY which showed high antihypertensive activity of moxonidine, and also its positive influence on metabolic parameters and mass of a body were published.

метаболический синдромартериальная гипертонияожирениемоксонидинменопаузаmetabolic syndromearterial hypertensionobesityindapamide retardReferencesЖернакова Ю.В. Клиническая характеристика различных вариантов течения метаболического синдрома и возможности влияния антигипертензивной терапии на уровень артериального давления, состояние углеводного, липидного обменов и выраженность ожирения у больных артериальной гипертонией и метаболическим синдромом. Автореф. дис.. д - ра мед. наук. М., 2012.Жернакова Ю.В. Клиническая характеристика различных вариантов течения метаболического синдрома и возможности влияния антигипертензивной терапии на уровень артериального давления, состояние углеводного, липидного обменов и выраженность ожирения у больных артериальной гипертонией и метаболическим синдромом. Автореф. дис.. д - ра мед. наук. М., 2012.Шарипова Г.М. Особенности поражения органов - мишеней у больных артериальной гипертонией в зависимости от наличия и отсутствия метаболического синдрома. Автореф. дис.. д - ра мед. наук. М., 2009.Шарипова Г.М. Особенности поражения органов - мишеней у больных артериальной гипертонией в зависимости от наличия и отсутствия метаболического синдрома. Автореф. дис.. д - ра мед. наук. М., 2009.Reaven G.M. Banting Lecture 1988. Role of insulin resistance in human disease. Diabetes 1988; 37: 1595–607.Reaven G.M. Banting Lecture 1988. Role of insulin resistance in human disease. Diabetes 1988; 37: 1595–607.Randle P.J, Garland P, Hales C et al. The glucose - fatty acid cycle: its role in insulin sensitivity and metabolic disturbance of diabetes mellitus. Lancet 1963; 1: 785–9.Randle P.J, Garland P, Hales C et al. The glucose - fatty acid cycle: its role in insulin sensitivity and metabolic disturbance of diabetes mellitus. Lancet 1963; 1: 785–9.Uysal K.T, Wiesbrock S.M, Marino M.W et al. Protection from obecity – induced insulin resistance in mice. Lacking TNF - a function. Nature 1997; 389: 610–4.Uysal K.T, Wiesbrock S.M, Marino M.W et al. Protection from obecity – induced insulin resistance in mice. Lacking TNF - a function. Nature 1997; 389: 610–4.Ferrannini E, Buzzigoli G, Bonadonna R et al. Insulin resistance in essential hypertension. N Engl J Med 1987; 317: 350–7.Ferrannini E, Buzzigoli G, Bonadonna R et al. Insulin resistance in essential hypertension. N Engl J Med 1987; 317: 350–7.Ernsberger P. Pharmacology of moxonidine: and I1 - imidazoline receptor agonist. J Cardiovasc Pharmacol 2000; 35 (7 Suppl. 4): s27–41.Ernsberger P. Pharmacology of moxonidine: and I1 - imidazoline receptor agonist. J Cardiovasc Pharmacol 2000; 35 (7 Suppl. 4): s27–41.Rosen P, Ohhy P, Gleichmann H. Experimental benefit of moxonidine on glucose metabolism and insulin secretion in the fructoseied rat. J Hypertens 1997; Suppl. 15: s31–8.Rosen P, Ohhy P, Gleichmann H. Experimental benefit of moxonidine on glucose metabolism and insulin secretion in the fructoseied rat. J Hypertens 1997; Suppl. 15: s31–8.Ernsberger P, Ishizuka T, Liu S et al. Mechanisms of antihyperglycemic effects of moxonidine in the obese spontaneously hypertensive Koletsky rat (SHROB). J Pharmacol Exp Ther 1999; 288: 139–47.Ernsberger P, Ishizuka T, Liu S et al. Mechanisms of antihyperglycemic effects of moxonidine in the obese spontaneously hypertensive Koletsky rat (SHROB). J Pharmacol Exp Ther 1999; 288: 139–47.Kirch W, Hutt H.J, Planitz V. Pharmacodynamic action and pharmacokinetics of moxonidine after single oral administration in hypertension patients. J Clin Pharmacol 1990; 30: 1088–95.Kirch W, Hutt H.J, Planitz V. Pharmacodynamic action and pharmacokinetics of moxonidine after single oral administration in hypertension patients. J Clin Pharmacol 1990; 30: 1088–95.Mitrovic V, Patyna W, Huting J et al. Hemodynamic and neurohumoral effects of moxonidine in patients with essential hypertension. Cardiovasc Drugs Ther 1991; 5 (6): 967–72.Mitrovic V, Patyna W, Huting J et al. Hemodynamic and neurohumoral effects of moxonidine in patients with essential hypertension. Cardiovasc Drugs Ther 1991; 5 (6): 967–72.Friedman J.E, Ishizuka T, Liu S et al. Antihyperglycemic activity of moxonidine: metabolic and molecular effects in obese spontaneously hypertensive rats. Blood Press 1998; Suppl. 3: 32–9.Friedman J.E, Ishizuka T, Liu S et al. Antihyperglycemic activity of moxonidine: metabolic and molecular effects in obese spontaneously hypertensive rats. Blood Press 1998; Suppl. 3: 32–9.Чазова И.Е., Мычка В.Б. Новые возможности в лечении больных с метаболическим синдромом. Результаты исследования ALMAZ. Системные гипертензии. 2006; 8 (2): 456–65.Чазова И.Е., Мычка В.Б. Новые возможности в лечении больных с метаболическим синдромом. Результаты исследования ALMAZ. Системные гипертензии. 2006; 8 (2): 456–65.Chazova I, Schlaich M.P. Improved hypertension control with the imidazoline agonist moxonidine in a multinational metabolic syndrome population: principal results of the MERSY Study. Intern J Hypertens 2013; 1–9.Chazova I, Schlaich M.P. Improved hypertension control with the imidazoline agonist moxonidine in a multinational metabolic syndrome population: principal results of the MERSY Study. Intern J Hypertens 2013; 1–9.Sharma A.M, Wagner T, Marsalek P. Moxonidine in the treatment of overweight and obese patients with the metabolic syndrome: a post marketing surveillance study. J Hum Hypertens 2004; 18: 669–75.Sharma A.M, Wagner T, Marsalek P. Moxonidine in the treatment of overweight and obese patients with the metabolic syndrome: a post marketing surveillance study. J Hum Hypertens 2004; 18: 669–75.Prichard B.N.C, Simmons R, Rooks J et al. A double - blind comparison of moxonidine and atenolol in the management of patients with mild to moderate hypertension. J Cardiovasc Pharmacol 1992; 20 (Suppl. 4): s45–9.Prichard B.N.C, Simmons R, Rooks J et al. A double - blind comparison of moxonidine and atenolol in the management of patients with mild to moderate hypertension. J Cardiovasc Pharmacol 1992; 20 (Suppl. 4): s45–9.Wolf R. The treatment of hypertensive patients with a calcium antagonist or moxonidine: a comparison. J Cardiovasc Pharmacol 1992; 20 (Suppl. 4): s42–4.Wolf R. The treatment of hypertensive patients with a calcium antagonist or moxonidine: a comparison. J Cardiovasc Pharmacol 1992; 20 (Suppl. 4): s42–4.Trieb G, Jager B, Hughes P.R et al. Long - term evaluation of the antihypertensive efficacy and tolerability of the orally - acting imidazoline I1-receptor agonist moxonidine. Eur J Clin Res 1995; 7: 227–40.Trieb G, Jager B, Hughes P.R et al. Long - term evaluation of the antihypertensive efficacy and tolerability of the orally - acting imidazoline I1-receptor agonist moxonidine. Eur J Clin Res 1995; 7: 227–40.Kjeldsen S.E, Naditch-Brule L, Perlini S et al. Increased prevalence of metabolic syndrome in uncontrolled hypertension across Europe: the global cardio metabolic risk profile in patients with hypertension disease survey. J Hypertens 2008; 26: 2064–70.Kjeldsen S.E, Naditch-Brule L, Perlini S et al. Increased prevalence of metabolic syndrome in uncontrolled hypertension across Europe: the global cardio metabolic risk profile in patients with hypertension disease survey. J Hypertens 2008; 26: 2064–70.Chazova I, Almazov V.A, Shlyakhto E. Moxonidine improves glycaemic control in mildly hypertensive, overweight patients: a comparison with metformin. Diabetes Obes Metab 2006; 8: 456–65.Chazova I, Almazov V.A, Shlyakhto E. Moxonidine improves glycaemic control in mildly hypertensive, overweight patients: a comparison with metformin. Diabetes Obes Metab 2006; 8: 456–65.James W.P, Caterson I.D, Coutinho W et al. Effect of sibutramine on cardiovascular outcomes in overweight and obese subjects. N Engl J Med 2010; 363: 905–17.James W.P, Caterson I.D, Coutinho W et al. Effect of sibutramine on cardiovascular outcomes in overweight and obese subjects. N Engl J Med 2010; 363: 905–17.Lambert E, Sari C.I, Dawood T et al. Sympathetic nervous system activity is associated with obesity - induced subclinical organ damage in young adults. Hypertension 2010; 56: 351–8.Lambert E, Sari C.I, Dawood T et al. Sympathetic nervous system activity is associated with obesity - induced subclinical organ damage in young adults. Hypertension 2010; 56: 351–8.Lambert G.W, Straznicky N.E, Lambert E.A et al. Sympathetic nervous activation in obesity and the metabolic syndrome – causes, consequences and therapeutic implications. Pharmacol Ther 2010; 126: 159–72.Lambert G.W, Straznicky N.E, Lambert E.A et al. Sympathetic nervous activation in obesity and the metabolic syndrome – causes, consequences and therapeutic implications. Pharmacol Ther 2010; 126: 159–72.Mancia G, Bousquet P, Elghozi J.L et al. The sympathetic nervous system and the metabolic syndrome. J Hypertens 2007; 25: 909–20.Mancia G, Bousquet P, Elghozi J.L et al. The sympathetic nervous system and the metabolic syndrome. J Hypertens 2007; 25: 909–20.Zidek W, Naditch-Brule L, Perlini S et al. Blood pressure control and components of the metabolic syndrome: the GOOD survey. Cardiovasc Diabet 2009; 8: 51.Zidek W, Naditch-Brule L, Perlini S et al. Blood pressure control and components of the metabolic syndrome: the GOOD survey. Cardiovasc Diabet 2009; 8: 51.

The authors declare that there are no conflicts of interest present.