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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">systhiper</journal-id><journal-title-group><journal-title xml:lang="ru">Системные гипертензии</journal-title><trans-title-group xml:lang="en"><trans-title>Systemic Hypertension</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2075-082X</issn><issn pub-type="epub">2542-2189</issn><publisher><publisher-name>LLC «ИнтерМедсервис»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.38109/2075-082X-2022-1-5-22</article-id><article-id custom-type="elpub" pub-id-type="custom">systhiper-3</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КОНСЕНСУС</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CONSENSUS</subject></subj-group></article-categories><title-group><article-title>Консенсус по ведению пациентов с гиперурикемией и высоким сердечно-сосудистым риском: 2022</article-title><trans-title-group xml:lang="en"><trans-title>Consensus on patients with hyperuricemia and high cardiovascular risk treatment: 2022</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9822-4357</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Чазова</surname><given-names>И. Е.</given-names></name><name name-style="western" xml:lang="en"><surname>Chazova</surname><given-names>I. E.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Чазова Ирина Евгеньевна, д-р мед. наук, проф., акад. РАН, зам. ген. дир. по научно-экспертной работе, рук. отдела гипертонии, НИИ клинической кардиологии им. А.Л. Мясникова</p><p>ул. 3-я Черепковская, д. 15а, г. Москва 121552</p><p>тел.: +7(495) 415-52-05</p></bio><bio xml:lang="en"><p>Irina E. Chazova (chairman), Prof., Dr. of Sci. (Med.), Academician of RAS, Deputy General Director for Scientific and Expert Work, Head of Hypertension Department</p><p>3rd Cherepkovskaya str., 15a, Moscow 121552</p><p>Phone: +7(495) 415-52-05</p></bio><email xlink:type="simple">c34h@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7895-9068</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Жернакова</surname><given-names>Ю. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Zhernakova</surname><given-names>Yu. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Жернакова Юлия Валерьевна, д-р мед. наук, проф., ученый секретарь НИИ клинической кардиологии им. А.Л. Мясникова</p><p>ул. 3-я Черепковская, д. 15а, г. Москва 121552</p><p>тел.: +7(495) 414-63-00</p></bio><bio xml:lang="en"><p>Yuliya V. Zhernakova, Prof., Dr. of Sci. (Med.), Scientific Secretary of the Institute of Clinical Cardiology named after A.L. Myasnikov</p><p>3rd Cherepkovskaya str., 15a, Moscow 121552</p><p>Phone: +7(495) 495-414-63-00</p><p> </p></bio><email xlink:type="simple">juli001@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2028-8748</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кисляк</surname><given-names>О. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Kislyak</surname><given-names>O. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кисляк Оксана Андреевна, д-р мед. наук, проф., зав. каф. факультетской терапии лечебного факультета</p><p>ул. Островитянова д. 1, г. Москва 117997</p></bio><bio xml:lang="en"><p>Oksana A. Kislyak, Prof., Dr. of Sci. (Med.), Head of the Department of Faculty Therapy</p><p>Ostrovitianov str. 1, Moscow 117997</p></bio><email xlink:type="simple">kisliakoa@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0758-5609</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Подзолков</surname><given-names>В. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Podzolkov</surname><given-names>V. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Подзолков Валерий Иванович, проф., д-р мед. наук, зав. каф. факультетской терапии №2</p><p>ул. Трубецкая, 8 стр. 2, г. Москва 119991</p></bio><bio xml:lang="en"><p>Valerij I. Podzolkov, Prof., Dr. of Sci. (Med.), Head of the Department of Faculty Therapy No. 2</p><p>st. Trubetskaya, 8 building 2, Moscow 119991</p></bio><email xlink:type="simple">podzolkov@list.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4534-9890</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ощепкова</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Oshchepkova</surname><given-names>E. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ощепкова Елена Владимировна, проф., д-р мед. наук, гл. науч. сотр. отдела гипертонии НИИ клинической кардиологии им.А.Л.Мясникова</p><p>ул. 3-я Черепковская, д. 15а, г. Москва 121552</p><p>тел.: +7 (495) 414-66-63</p></bio><bio xml:lang="en"><p>Elena V. Oshchepkova, Prof., Dr. of Sci. (Med.), Chief Researcher, Department of Hypertension, A.L. Myasnikov Research Institute of Clinical Cardiology</p><p>3rd Cherepkovskaya str., 15a, Moscow 121552</p><p>Phone: +7 (495) 414-66-63</p></bio><email xlink:type="simple">arthyplab@list.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5820-1759</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Миронова</surname><given-names>О. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Mironova</surname><given-names>O. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Миронова Ольга Юрьевна, д-р мед. наук, проф. каф. факультетской терапии №1 Института клинической медицины им. Н.В. Склифосовского</p><p>ул. Трубецкая, 8 стр. 2, г. Москва 119991</p><p>тел.: +7(499) 248-05-53</p></bio><bio xml:lang="en"><p>Olga Iu. Mironova, Prof., Dr. of Sci. (Med.), Associate Professor of the Department of Faculty Therapy No. 1, N.V. Sklifosovsky Institute of Clinical Medicine</p><p>st. Trubetskaya, 8 building 2, Moscow 119991</p><p>Phone: +7(499) 248-05-53</p></bio><email xlink:type="simple">mironova_o_yu@staff.sechenov.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5215-4894</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Блинова</surname><given-names>Н. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Blinova</surname><given-names>N. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Блинова Наталия Владимировна, канд. мед. наук, ст. науч. сотр. отдела гипертонии НИИ клинической кардиологии им. А.Л. Мясникова</p><p>ул. 3-я Черепковская, д. 15а, г. Москва 121552</p><p>тел.: +7(495)414-61-86</p></bio><bio xml:lang="en"><p>Nataliya V. Blinova, Cand. of Sci. (Med.), Senior Researcher, Department of Hypertension, A.L. Myasnikov Research Institute of Clinical Cardiology</p><p>3rd Cherepkovskaya str., 15a, Moscow 121552</p><p>Phone: +7 (495) 414-61-86</p></bio><email xlink:type="simple">nat-cardio1@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБУ «Национальный медицинский исследовательский центр кардиологии имени академика Е.И. Чазова» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>E.I. Chazov National Medical Research Center of Cardiology</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Российский Национальный Исследовательский Медицинский Университет им. Н.И. Пирогова</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Pirogov Russian National Research Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>ФГАОУ Первый МГМУ им. И. М. Сеченова (Сеченовский Университет) МЗ РФ</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Sechenov First Moscow State Medical University (Sechenov University)</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2022</year></pub-date><pub-date pub-type="epub"><day>16</day><month>10</month><year>2022</year></pub-date><volume>19</volume><issue>1</issue><fpage>5</fpage><lpage>22</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Чазова И.Е., Жернакова Ю.В., Кисляк О.А., Подзолков В.И., Ощепкова Е.В., Миронова О.Ю., Блинова Н.В., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Чазова И.Е., Жернакова Ю.В., Кисляк О.А., Подзолков В.И., Ощепкова Е.В., Миронова О.Ю., Блинова Н.В.</copyright-holder><copyright-holder xml:lang="en">Chazova I.E., Zhernakova Y.V., Kislyak O.A., Podzolkov V.I., Oshchepkova E.V., Mironova O.Y., Blinova N.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.syst-hypertension.ru/jour/article/view/3">https://www.syst-hypertension.ru/jour/article/view/3</self-uri><abstract><p>Со времени выхода первого консенсуса по ведению пациентов с гиперурикемией и высоким сердечно-сосудистым риском прошло 3 года. За это время появились новые данные, которые подтверждают важность контроля мочевой кислоты как фактора риска сердечно-сосудистых осложнений и позволяют оптимизировать алгоритм ведения таких пациентов. Исследования, проведенные после выхода первого консенсуса, позволили определить новые пороговые значения гиперурикемии в отношении сердечно-сосудистого риска. Настоящий консенсус регламентирует назначение уратснижающей терапии в зависимости от тяжести выявленной гиперурикемии. Однако несмотря на то, что большая совокупность данных демонстрирует положительное влияние уратснижающей терапии на сердечно-сосудистый прогноз, есть необходимость в дополнительных доказательствах в поддержку лечения бессимптомной гиперурикемии.</p></abstract><trans-abstract xml:lang="en"><p>After 3 years since the release of the first consensus on the management of patients with hyperuricemia and high cardiovascular risk. During this time, new data appeared that confirm the importance of uric acid control as a risk factor for cardiovascular complications and allow optimizing the algorithm for managing such patients. Studies since the first consensus emerged have identified new hyperuricemia thresholds for cardiovascular risk. The present consensus regulates the prescription of urate-lowering therapy depending on the severity of the detected hyperuricemia. However, although a large body of data demonstrates a positive effect of urate-lowering therapy on the cardiovascular prognosis, there is a need for additional evidence to support the treatment of asymptomatic hyperuricemia.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>гиперурикемия</kwd><kwd>мочевая кислота</kwd><kwd>фактор риска</kwd><kwd>сердечно-сосудистый риск</kwd><kwd>артериальная гипертония</kwd><kwd>ингибитор ксантиноксидазы</kwd><kwd>аллопуринол</kwd></kwd-group><kwd-group xml:lang="en"><kwd>hyperuricemia</kwd><kwd>uric acid</kwd><kwd>risk factor</kwd><kwd>cardiovascular risk</kwd><kwd>arterial hypertension</kwd><kwd>xanthine oxidase inhibitor</kwd><kwd>allopurinol</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Bryan Williams, Giuseppe Mancia, Wilko Spiering, Enrico Agabiti Rosei, Michel Azizi, et al. 2018 ESC/ESH Guidelines for the management of arterial hypertension. 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