<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">systhiper</journal-id><journal-title-group><journal-title xml:lang="ru">Системные гипертензии</journal-title><trans-title-group xml:lang="en"><trans-title>Systemic Hypertension</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2075-082X</issn><issn pub-type="epub">2542-2189</issn><publisher><publisher-name>LLC «ИнтерМедсервис»</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">systhiper-308</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КАРДИОНЕВРОЛОГИЯ</subject></subj-group></article-categories><title-group><article-title>Cовременные представления об идеальной комбинации антигипертензивных препаратов для профилактики инсульта</article-title><trans-title-group xml:lang="en"><trans-title></trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Остроумова</surname><given-names>О. Д.</given-names></name></name-alternatives><email xlink:type="simple">ostroumova.olga@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Фомина</surname><given-names>В. М.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гусева</surname><given-names>Т. Ф.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff xml:lang="ru" id="aff-1"><institution>ГБОУ ВПО Московский государственный медико-стоматологический университет им. А.И.Евдокимова Минздрава России; ГБОУ ВПО Первый Московский государственный медицинский университет им. И.М.Сеченова Минздрава России</institution><country>Russian Federation</country></aff><aff xml:lang="ru" id="aff-2"><institution>ГБОУ ВПО Московский государственный медико-стоматологический университет им. А.И.Евдокимова Минздрава России</institution><country>Russian Federation</country></aff><pub-date pub-type="collection"><year>2013</year></pub-date><pub-date pub-type="epub"><day>23</day><month>12</month><year>2022</year></pub-date><volume>10</volume><issue>3</issue><fpage>71</fpage><lpage>76</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Остроумова О.Д., Фомина В.М., Гусева Т.Ф., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Остроумова О.Д., Фомина В.М., Гусева Т.Ф.</copyright-holder><copyright-holder xml:lang="en">Остроумова О.Д., Фомина В.М., Гусева Т.Ф.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.syst-hypertension.ru/jour/article/view/308">https://www.syst-hypertension.ru/jour/article/view/308</self-uri><abstract><p>Статья посвящена выбору антигипертензивного препарата для профилактики инсульта. Подробно рассмотрены преимущества и механизмы церебропротективного действия лозартана и амлодипина. Приведены данные большого количества исследований, доказывающие эффективность данных препаратов в профилактике цереброваскулярных осложнений.</p></abstract><kwd-group xml:lang="ru"><kwd>артериальная гипертония</kwd><kwd>инсульт</kwd><kwd>антигипертензивная терапия</kwd><kwd>антагонисты рецепторов к ангиотензину II</kwd><kwd>лозартан</kwd><kwd>антагонисты кальция</kwd><kwd>амлодипин</kwd><kwd>фиксированные комбинации антигипертензивных препаратов</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Смертность населения Российской Федерации, 1998 г. (статистические материалы). М.: Минздрав РФ, 2006.</mixed-citation><mixed-citation xml:lang="en">Смертность населения Российской Федерации, 1998 г. (статистические материалы). М.: Минздрав РФ, 2006.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Гусев Е.И., Скворцова В.И., Стаховская Л.В. Проблема инсульта в Российской Федерации: время активных совместных действий. Журн. неврологии и психиатрии. 2007; 8: 4–10.</mixed-citation><mixed-citation xml:lang="en">Гусев Е.И., Скворцова В.И., Стаховская Л.В. Проблема инсульта в Российской Федерации: время активных совместных действий. Журн. неврологии и психиатрии. 2007; 8: 4–10.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Диагностика и лечение артериальной гипертензии. Системные гипертензии. 2010; 3: 5–26.</mixed-citation><mixed-citation xml:lang="en">Диагностика и лечение артериальной гипертензии. Системные гипертензии. 2010; 3: 5–26.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Lewington S, Clarke R, Qizilbash N et al. Prospective Studies Collaboration. Age - specific relevance of usual blood pressure to vascular mortality: a meta - analysis of individual data for one million adults in 61 prospective studies. Lancet 2002; 360: 1903–13.</mixed-citation><mixed-citation xml:lang="en">Lewington S, Clarke R, Qizilbash N et al. Prospective Studies Collaboration. Age - specific relevance of usual blood pressure to vascular mortality: a meta - analysis of individual data for one million adults in 61 prospective studies. Lancet 2002; 360: 1903–13.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Staessen J.A, Wang J-G, Thijs L. Cardiovascular prevention and blood pressure reduction: a quantitative overview updated until 1 March 2003. J Hypertens 2003; 21: 1055–76.</mixed-citation><mixed-citation xml:lang="en">Staessen J.A, Wang J-G, Thijs L. Cardiovascular prevention and blood pressure reduction: a quantitative overview updated until 1 March 2003. J Hypertens 2003; 21: 1055–76.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Reboldi G, Angeli F, Cavallini C et al. Comparison between angiotensin - converting enzyme inhibitors and angiotensin receptor blockers on the risk of myocardial infarction, stroke and death: a meta - analysis. J Hypertens 2008; 26 (7): 1282–9.</mixed-citation><mixed-citation xml:lang="en">Reboldi G, Angeli F, Cavallini C et al. Comparison between angiotensin - converting enzyme inhibitors and angiotensin receptor blockers on the risk of myocardial infarction, stroke and death: a meta - analysis. J Hypertens 2008; 26 (7): 1282–9.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Dahlöf B, Devereux R.B, Kjeldsen S.E et al. Cardiovascular morbidity and mortality in the Losartan Intervention For Endpoint reduction in hypertension study (LIFE). Lancet 2002; 359: 995–1003.</mixed-citation><mixed-citation xml:lang="en">Dahlöf B, Devereux R.B, Kjeldsen S.E et al. Cardiovascular morbidity and mortality in the Losartan Intervention For Endpoint reduction in hypertension study (LIFE). Lancet 2002; 359: 995–1003.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Dahlöf B, Devereux R.B, de Faire U et al. The Losartan Intervention For Endpoint reduction (LIFE) in hypertension study. Am J Hypertens 1997; 10: 705–13.</mixed-citation><mixed-citation xml:lang="en">Dahlöf B, Devereux R.B, de Faire U et al. The Losartan Intervention For Endpoint reduction (LIFE) in hypertension study. Am J Hypertens 1997; 10: 705–13.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Verdecchia P Porcellati C, Reboldi G et al. Left ventricular hypertrophy as an independent predictor of acute cerebrovascular events in essential hypertension. Circulation 2001; 104: 2039–44.</mixed-citation><mixed-citation xml:lang="en">Verdecchia P Porcellati C, Reboldi G et al. Left ventricular hypertrophy as an independent predictor of acute cerebrovascular events in essential hypertension. Circulation 2001; 104: 2039–44.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Верещагин Н.В. Гетерогенность инсульта в клинической практике. Атмосфера. Нервные болезни. 2004; 1: 19–20.</mixed-citation><mixed-citation xml:lang="en">Верещагин Н.В. Гетерогенность инсульта в клинической практике. Атмосфера. Нервные болезни. 2004; 1: 19–20.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Dempsey R.J, Diana A.L, Moore R.W. Thickness of carotid artery atherosclerotic plaque and ischemic risk. Neurosurgery 1990; 27 (3): 343–8.</mixed-citation><mixed-citation xml:lang="en">Dempsey R.J, Diana A.L, Moore R.W. Thickness of carotid artery atherosclerotic plaque and ischemic risk. Neurosurgery 1990; 27 (3): 343–8.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Olsen M.H, Wachtell K, Neland K et al. Losartan but not atenolol reduce carotid artery hypertrophy in essential hypertension. A LIFE substudy. Blood Press 2005; 14: 177–83.</mixed-citation><mixed-citation xml:lang="en">Olsen M.H, Wachtell K, Neland K et al. Losartan but not atenolol reduce carotid artery hypertrophy in essential hypertension. A LIFE substudy. Blood Press 2005; 14: 177–83.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Sonoda M, Aoyagi T, Takenaka K et al. A One-Year Study of the Antiatherosclerotic Effect of the Angiotensin-II Receptor Blocker Losartan in Hypertensive Patients (A Comparison With Angiotensin-Converting Enzyme Inhibitors). Int Heart J 2008; 49 (1): 95–103.</mixed-citation><mixed-citation xml:lang="en">Sonoda M, Aoyagi T, Takenaka K et al. A One-Year Study of the Antiatherosclerotic Effect of the Angiotensin-II Receptor Blocker Losartan in Hypertensive Patients (A Comparison With Angiotensin-Converting Enzyme Inhibitors). Int Heart J 2008; 49 (1): 95–103.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Strawn W.B, Chappell M.C, Dean R.H et al. Inhibition of early atherogenesis by losartan in monkeys with diet - induced hypercholesterolemia. Circulation 2000; 101: 1586–93.</mixed-citation><mixed-citation xml:lang="en">Strawn W.B, Chappell M.C, Dean R.H et al. Inhibition of early atherogenesis by losartan in monkeys with diet - induced hypercholesterolemia. Circulation 2000; 101: 1586–93.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Schiffrin E.L, Park J.B, Intengan H.D et al. Correction of arterial structure and endothelial dysfunction in human essential hypertension by the angiotensin receptor antagonist losartan. Circulation 2000; 101: 1653–9.</mixed-citation><mixed-citation xml:lang="en">Schiffrin E.L, Park J.B, Intengan H.D et al. Correction of arterial structure and endothelial dysfunction in human essential hypertension by the angiotensin receptor antagonist losartan. Circulation 2000; 101: 1653–9.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Prasad A, Tupas-Habib T, Schenke W.H et al. Acute and chronic angiotensin-1 receptor antagonism reverses endothelial dysfunction in atherosclerosis. Circulation 2000; 101: 2349–54.</mixed-citation><mixed-citation xml:lang="en">Prasad A, Tupas-Habib T, Schenke W.H et al. Acute and chronic angiotensin-1 receptor antagonism reverses endothelial dysfunction in atherosclerosis. Circulation 2000; 101: 2349–54.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Cheetham C, Collis J, O’Driscoll G et al. Losartan, an angiotensin type 1 receptor antagonist, improves endothelial function in non - insulin - dependent diabetes. J Am Coll Cardiol 2000; 36 (5): 1461–6.</mixed-citation><mixed-citation xml:lang="en">Cheetham C, Collis J, O’Driscoll G et al. Losartan, an angiotensin type 1 receptor antagonist, improves endothelial function in non - insulin - dependent diabetes. J Am Coll Cardiol 2000; 36 (5): 1461–6.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Hornig B, Landmesser U, Kohler C et al. Comparative effect of ACE inhibition and angiotensin II type 1 receptor antagonism on bioavailability of nitric oxide in patients with coronary artery disease: Role of superoxide dismutase. Circulation 2001; 103: 799–805.</mixed-citation><mixed-citation xml:lang="en">Hornig B, Landmesser U, Kohler C et al. Comparative effect of ACE inhibition and angiotensin II type 1 receptor antagonism on bioavailability of nitric oxide in patients with coronary artery disease: Role of superoxide dismutase. Circulation 2001; 103: 799–805.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Guerra-Cuesta J.I, Montón M, Rodriguez-Feo J.A et al. Effect of losartan on human platelet activation. J Hypertens 1999; 17: 447–52.</mixed-citation><mixed-citation xml:lang="en">Guerra-Cuesta J.I, Montón M, Rodriguez-Feo J.A et al. Effect of losartan on human platelet activation. J Hypertens 1999; 17: 447–52.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Erdem Y, Usalan C, Haznedaroğlu I.C et al. Effects of angiotensin converting enzyme and angiotensin II receptor inhibition on impaired fibrinolysis in systemic hypertension. Am J Hypertens 1999; 11: 1071–6.</mixed-citation><mixed-citation xml:lang="en">Erdem Y, Usalan C, Haznedaroğlu I.C et al. Effects of angiotensin converting enzyme and angiotensin II receptor inhibition on impaired fibrinolysis in systemic hypertension. Am J Hypertens 1999; 11: 1071–6.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Levy P.J, Yunis C, Owen J et al. Inhibition of platelet aggregability by losartan in essential hypertension. Am J Cardiol 2000; 86: 1188–92.</mixed-citation><mixed-citation xml:lang="en">Levy P.J, Yunis C, Owen J et al. Inhibition of platelet aggregability by losartan in essential hypertension. Am J Cardiol 2000; 86: 1188–92.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Fogari R, Zoppi A, Malamani G et al. Effects of four angiotensin II-receptor antagonists on fibrinolysis in postmenopausal women with hypertension. Curr Ther Res Clin Exp 2001; 62: 68–78.</mixed-citation><mixed-citation xml:lang="en">Fogari R, Zoppi A, Malamani G et al. Effects of four angiotensin II-receptor antagonists on fibrinolysis in postmenopausal women with hypertension. Curr Ther Res Clin Exp 2001; 62: 68–78.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Krämer C, Sunkomat J, Witte J et al. Angiotensin II receptor - independent antiinflammatory and antiaggregatory properties of losartan: Role of the active metabolite EXP3179. Circ Res 2002; 90: 770–6.</mixed-citation><mixed-citation xml:lang="en">Krämer C, Sunkomat J, Witte J et al. Angiotensin II receptor - independent antiinflammatory and antiaggregatory properties of losartan: Role of the active metabolite EXP3179. Circ Res 2002; 90: 770–6.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Wolf P.A, Abbott R.D, Kannel W.B. Atrial fibrillation as an independent risk factor for stroke: the Framingham Study. Stroke 1991; 22: 983–8.</mixed-citation><mixed-citation xml:lang="en">Wolf P.A, Abbott R.D, Kannel W.B. Atrial fibrillation as an independent risk factor for stroke: the Framingham Study. Stroke 1991; 22: 983–8.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Wachtell K, Lehto M, Gerdts E et al. Angiotensin II receptor blockade reduces new - onset atrial fibrillation and subsequent stroke compared to atenolol: The LIFE Study. J Am Coll Cardiol 2005; 45: 712–9.</mixed-citation><mixed-citation xml:lang="en">Wachtell K, Lehto M, Gerdts E et al. Angiotensin II receptor blockade reduces new - onset atrial fibrillation and subsequent stroke compared to atenolol: The LIFE Study. J Am Coll Cardiol 2005; 45: 712–9.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Devereux R.B, Bella J, Boman K et al. Echocardiographic left ventricular geometry in hypertensive patients with electrocardiographic left ventricular hypertrophy: The LIFE Study. Blood Press 2001; 10: 74–82.</mixed-citation><mixed-citation xml:lang="en">Devereux R.B, Bella J, Boman K et al. Echocardiographic left ventricular geometry in hypertensive patients with electrocardiographic left ventricular hypertrophy: The LIFE Study. Blood Press 2001; 10: 74–82.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Wachtell K, Hornestam B, Lehto M et al. Cardiovascular morbidity and mortality in hypertensive patients with atrial fibrillation: The LIFE study. J Am Coll Cardiol 2005; 45: 705–11.</mixed-citation><mixed-citation xml:lang="en">Wachtell K, Hornestam B, Lehto M et al. Cardiovascular morbidity and mortality in hypertensive patients with atrial fibrillation: The LIFE study. J Am Coll Cardiol 2005; 45: 705–11.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Olsen M.H, Wachtell K, Bella J.N et al. Aortic valve sclerosis and albuminuria predict cardiovascular events independently in hypertension: a Losartan Intervention For Endpoint reduction in hypertension (LIFE) substudy. Am J Hypertens 2005; 18: 1430–6.</mixed-citation><mixed-citation xml:lang="en">Olsen M.H, Wachtell K, Bella J.N et al. Aortic valve sclerosis and albuminuria predict cardiovascular events independently in hypertension: a Losartan Intervention For Endpoint reduction in hypertension (LIFE) substudy. Am J Hypertens 2005; 18: 1430–6.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Ibsen H, Wachtell K, Olsen M.H et al., for the LIFE Substudy. Does albuminuria predict cardiovascular outcome on treatment with losartan versus atenolol in hypertension with left ventricular hypertrophy? A LIFE substudy. J Hypertens 2004; 22: 1805–11.</mixed-citation><mixed-citation xml:lang="en">Ibsen H, Wachtell K, Olsen M.H et al., for the LIFE Substudy. Does albuminuria predict cardiovascular outcome on treatment with losartan versus atenolol in hypertension with left ventricular hypertrophy? A LIFE substudy. J Hypertens 2004; 22: 1805–11.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Kobel F, Gregorova I, Sonka J. Hyperuricaemia in hypertension. Lancet 1965; 1: 519–20.</mixed-citation><mixed-citation xml:lang="en">Kobel F, Gregorova I, Sonka J. Hyperuricaemia in hypertension. Lancet 1965; 1: 519–20.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Kinsey D, Walther R, Sise H.S et al. Incidence of hyperuricaemia in 400 hypertensive patients. Circulation 1961; 24: 972–3.</mixed-citation><mixed-citation xml:lang="en">Kinsey D, Walther R, Sise H.S et al. Incidence of hyperuricaemia in 400 hypertensive patients. Circulation 1961; 24: 972–3.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">France L.V, Pahor M, Di Bari M et al. Serum uric acid, diuretic treatment and risk of cardiovascular events in the Systolic Hypertension in the Elderly Program (SHEP). J Hypertens 2000; 18: 1149–54.</mixed-citation><mixed-citation xml:lang="en">France L.V, Pahor M, Di Bari M et al. Serum uric acid, diuretic treatment and risk of cardiovascular events in the Systolic Hypertension in the Elderly Program (SHEP). J Hypertens 2000; 18: 1149–54.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Hoieggen A, Alderman M.H, Kjeldsen S.E et al. The impact of serum uric acid on cardiovascular outcomes in the LIFE study. Kidney Int 2004; 65: 1041–9.</mixed-citation><mixed-citation xml:lang="en">Hoieggen A, Alderman M.H, Kjeldsen S.E et al. The impact of serum uric acid on cardiovascular outcomes in the LIFE study. Kidney Int 2004; 65: 1041–9.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Sweet C.S, Bradstreet D.C, Berman R.S et al. Pharmacodynamic activity of intravenous E-3174, an angiotensin II antagonist, in patients with essential hypertension. Am J Hypertens 1994; 7 (12): 1035–40.</mixed-citation><mixed-citation xml:lang="en">Sweet C.S, Bradstreet D.C, Berman R.S et al. Pharmacodynamic activity of intravenous E-3174, an angiotensin II antagonist, in patients with essential hypertension. Am J Hypertens 1994; 7 (12): 1035–40.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Burnier M, Hagmann M, Nussberger I et al. Short - term and sustained renal effects of angiotensin II receptor blockade in healthy subjects. Hypertension 1995; 25 (4p 1): 602–9.</mixed-citation><mixed-citation xml:lang="en">Burnier M, Hagmann M, Nussberger I et al. Short - term and sustained renal effects of angiotensin II receptor blockade in healthy subjects. Hypertension 1995; 25 (4p 1): 602–9.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Shahinfar S, Simpson R, Carides A et al. Safety of losartan in hypertensive patients with asymptomatic hyperuricemia. JASN 1997; 8: 322.</mixed-citation><mixed-citation xml:lang="en">Shahinfar S, Simpson R, Carides A et al. Safety of losartan in hypertensive patients with asymptomatic hyperuricemia. JASN 1997; 8: 322.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Pitt B, Byington R.P, Furberg C.D et al. Effect of amlodipine on progression of atherosclerosis and the occurrence of clinical events. PREVENT investigators. Circulation 2000; 102 (13): 1503–10.</mixed-citation><mixed-citation xml:lang="en">Pitt B, Byington R.P, Furberg C.D et al. Effect of amlodipine on progression of atherosclerosis and the occurrence of clinical events. PREVENT investigators. Circulation 2000; 102 (13): 1503–10.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Webb A.J.S, Fischer U, Mehta Z, Rothwell P.M. Effects of antihypertensive - drug class on interindividual variation in BP and risk of stroke: a systematic review and meta - analysis. Lancet 2010; 375: 906–15.</mixed-citation><mixed-citation xml:lang="en">Webb A.J.S, Fischer U, Mehta Z, Rothwell P.M. Effects of antihypertensive - drug class on interindividual variation in BP and risk of stroke: a systematic review and meta - analysis. Lancet 2010; 375: 906–15.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Rothwell P.M, Webb A.J.S. Effect of Dose and Combination of Antihypertensives on Interindividual Blood Pressure Variability: A Systematic Review. Stroke 2011; 42: 2860–5.</mixed-citation><mixed-citation xml:lang="en">Rothwell P.M, Webb A.J.S. Effect of Dose and Combination of Antihypertensives on Interindividual Blood Pressure Variability: A Systematic Review. Stroke 2011; 42: 2860–5.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Rothwell P.M, Howard S.C, Dolan E et al. Prognostic significance of visit - to - visit variability, maximum systolic blood pressure, and episodic hypertension. Lancet 2010; 375: 895–905.</mixed-citation><mixed-citation xml:lang="en">Rothwell P.M, Howard S.C, Dolan E et al. Prognostic significance of visit - to - visit variability, maximum systolic blood pressure, and episodic hypertension. Lancet 2010; 375: 895–905.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
