systhiperСистемные гипертензииSystemic Hypertension2075-082X2542-2189LLC «ИнтерМедсервис»systhiper-321Research ArticleСТАТЬИARTICLESСовременные возможности медикаментозной терапии артериальной гипертензии. Место кандесартанаModern possibilities of hypertension drug therapy. Candesartan and its place in the therapyБарбарашО. Л.BarbarashO. L.noemail@neicon.ruКашталапВ. В.KashtalapV. V.Olb61@mail.ruФГБУ Научно-исследовательский институт комплексных проблем сердечно-сосудистых заболеваний Сибирского отделения РАМН; ГБОУ ВПО Кемеровская государственная медицинская академия Минздрава РоссииRussian Federation2013231220221045558Copyright © Барбараш О.Л., Кашталап В.В., 20222022Барбараш О.Л., Кашталап В.В.Barbarash O.L., Kashtalap V.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.syst-hypertension.ru/jour/article/view/321

Артериальная гипертензия (АГ) остается одним из основных сердечно-сосудистых заболеваний у взрослого населения и основным фактором сердечно-сосудистой и цереброваскулярной заболеваемости и смертности. Медикаментозная терапия АГ приводит к снижению кардиоваскулярного риска посредством влияния на уровень артериального давления. Ренин-ангиотензин-альдостероновая система (РААС) играет ключевую роль в формировании АГ, медикаментозная блокада ее составляющих может значимо улучшить прогноз больных. Основными средствами, блокирующими РААС, являются ингибиторы ангиотензинпревращающего фермента и антагонисты рецепторов ангиотензина II (АРА II, сартаны). Препараты обоих классов показали свою высокую антигипертензивную эффективность. При этом АРА II – это препараты почти с идеальной переносимостью. Однако в последнее время самостоятельная роль сартанов в лечении АГ подвергается сомнению. Обзор актуальной доказательной базы сартанов с фокусом на современный антигипертензивный препарат кандесартана цилексетил и явился целью настоящей работы.

Arterial hypertension (AH) remains the one of the major cardiovascular diseases in the adult population and a major factor in cardiovascular and cerebrovascular morbidity and mortality. Drug therapy of hypertension leads to a reduction of cardiovascular risk by affecting blood pressure. Renin-angiotensin-aldosterone system (RAAS) plays a key role in the formation of hypertension, as the drug blockade of its components can significantly improve the prognosis of patients. The principal means of blocking the RAAS are angiotensin-converting enzyme (ACE) inhibitors and angiotensin receptor antagonists II (ARA II, sartans). Both classes of drugs have shown their high antihypertensive efficacy, with the ARA II having almost perfect portability. Recently, however, sartans’independent rolein the treatment of hypertension has been questioned. Date overview of the evidence base of sartans with a focus on modern antihypertensive drug called candesartan cilexetil was the following work’s objective.

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The authors declare that there are no conflicts of interest present.