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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">systhiper</journal-id><journal-title-group><journal-title xml:lang="ru">Системные гипертензии</journal-title><trans-title-group xml:lang="en"><trans-title>Systemic Hypertension</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2075-082X</issn><issn pub-type="epub">2542-2189</issn><publisher><publisher-name>LLC «ИнтерМедсервис»</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">systhiper-331</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КАРДИОЛОГИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CARDIOLOGY</subject></subj-group></article-categories><title-group><article-title>Практические аспекты применения фиксированных комбинаций в лечении артериальной гипертензии</article-title><trans-title-group xml:lang="en"><trans-title>Practical aspects of fixed combinations in the treatment of hypertension</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Огарков</surname><given-names>М. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Ogarkov</surname><given-names>M. Yu.</given-names></name></name-alternatives><email xlink:type="simple">ogarmu@cardio.kem.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Баранова</surname><given-names>М. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Baranova</surname><given-names>M. N.</given-names></name></name-alternatives><email xlink:type="simple">baranov1944@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Скрипченко</surname><given-names>А. Е.</given-names></name><name name-style="western" xml:lang="en"><surname>Skripchenko</surname><given-names>A. E.</given-names></name></name-alternatives><email xlink:type="simple">scripae@cardio.kem.ru</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff xml:lang="ru" id="aff-1"><institution>ГБОУ ДПО Новокузнецкий государственный институт усовершенствования врачей Минздрава России</institution><country>Russian Federation</country></aff><aff xml:lang="ru" id="aff-2"><institution>ФГБУ Научно-исследовательский институт комплексных проблем сердечно-сосудистых заболеваний СО РАМН</institution><country>Russian Federation</country></aff><pub-date pub-type="collection"><year>2014</year></pub-date><pub-date pub-type="epub"><day>23</day><month>12</month><year>2022</year></pub-date><volume>11</volume><issue>1</issue><fpage>22</fpage><lpage>25</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Огарков М.Ю., Баранова М.Н., Скрипченко А.Е., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Огарков М.Ю., Баранова М.Н., Скрипченко А.Е.</copyright-holder><copyright-holder xml:lang="en">Ogarkov M.Y., Baranova M.N., Skripchenko A.E.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.syst-hypertension.ru/jour/article/view/331">https://www.syst-hypertension.ru/jour/article/view/331</self-uri><abstract><p>Артериальная гипертензия - ведущая причина возникновения инфарктов и инсультов. Достижение целевого уровня артериального давления (АД) при артериальной гипертензии является основным условием оптимизации прогноза в отношении сердечно - сосудистой заболеваемости и смертности. Для решения этой задачи значительная часть больных нуждаются в применении антигипертензивных препаратов, при этом у 70-80% целевой уровень АД может быть достигнут при использовании комбинированной терапии. Фиксированные комбинации антигипертензивных препаратов повышают приверженность пациентов лечению и обеспечивают лучшую органопротекцию. Новая фиксированная комбинация высокоселективного β-адреноблокатора бисопролола и антагониста кальция амлодипина позволяет достичь целевого уровня АД у 82,5% больных при минимальной частоте побочных эффектов.</p></abstract><trans-abstract xml:lang="en"><p>Hypertension is a leading cause of heart attacks and strokes. Reaching target blood pressure (BP) in hypertension is the main condition optimization outlook for cardiovascular morbidity and mortality. To solve this problem in a substantial portion of patients, who are in need of antihypertensive drugs, wherein 70-80% of the target blood pressure can be achieved using a combination therapy. Fixed combinations of antihypertensive drugs increase treatment compliance and provide better organ protection. The new fixed combination of highly selective β-blocker bisoprolol and the calcium antagonist amlodipine can achieve target BP levels in 82,5% of patients with a minimum frequency of side effects.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>артериальная гипертензия</kwd><kwd>комбинированная терапия</kwd><kwd>фиксированные комбинации</kwd><kwd>бисопролол</kwd><kwd>амлодипин</kwd><kwd>Конкор АМ</kwd></kwd-group><kwd-group xml:lang="en"><kwd>hypertension</kwd><kwd>combination therapy</kwd><kwd>fixed combinations</kwd><kwd>bisoprolol</kwd><kwd>amlodipine</kwd><kwd>Concor AM</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Оганов Р.Г., Тимофеева Т.Н., Колтунов И.Е. и др. Эпидемиология артериальной гипертонии в России. Результаты федерального мониторинга 2003-2010 гг. 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