systhiperСистемные гипертензииSystemic Hypertension2075-082X2542-2189LLC «ИнтерМедсервис»systhiper-351Research ArticleМЕТАБОЛИЧЕСКИЕ НАРУШЕНИЯMETABOLIC DISTURBANCESМеханизмы развития сердечно-сосудистых заболеваний и сахарного диабета типа 2: роль инсулинорезистентности, гиперинсулинемии и гипоадипонектинемии. Вопросы коррекцииThe mechanisms of developmentcardiovascular disease and type 2 diabetes: the role of insulin resistance, hyperinsulinemia and hypoadiponektinemia. Treatment and managementШишковаВ. Н.ShishkovaV. N.noemail@neicon.ruГУЗ Центр патологии речи и нейрореабилитации, МоскваRussian Federation2014231220221124853Copyright © Шишкова В.Н., 20222022Шишкова В.Н.Shishkova V.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.syst-hypertension.ru/jour/article/view/351

Согласно современным представлениям первичная инсулинорезистентность играет важную роль в развитии не только сахарного диабета, но и его сердечно-сосудистых осложнений, таких как артериальная гипертензия, атеросклероз, сердечная недостаточность, фибрилляция предсердий. Защитный механизм, противостоящий развитию данных заболеваний, включает секрецию адипонектина клетками жировой ткани. Возможности современного антигипертензивного препарата из группы блокаторов рецептора ангиотензина - телмисартана в противодействии прогрессии инсулинорезистентности и значимом увеличении секреции адипонектина делают его применение патогенетически обоснованным у большинства пациентов с артериальной гипертензией.

In the current paradigm, the primary insulin resistance plays a central role in the development of not only diabetes but also associated with cardiovascular complications, such as arterial hypertension, arteriosclerosis, heart failure, atrial fibrillation. Defense mechanism involves the secretion of adiponectin from adipoctyes and thus helps to block the development of these diseases. Modern antihypertensive treatment options of angiotensin-receptor blocker telmisartan show that, telmisartan can be used in patients with arterial hypertension because of improving insulin resistance and increasing adiponectin levels.

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The authors declare that there are no conflicts of interest present.