systhiperСистемные гипертензииSystemic Hypertension2075-082X2542-2189LLC «ИнтерМедсервис»systhiper-370Research ArticleОБЗОРЫB-адреноблокаторы‌‌ при сердечно-сосудистых заболеваниях: фокус на метопрололBeta-adrenergic blocking agent in cardiovascular disease: focus on metoprololБарышниковаГ. А.BaryshnikovG. A.noemail@neicon.ruСтепановаИ. И.StepanovaI. I.noemail@neicon.ruКудрявцеваН. А.KudryavtsevaN. A.noemail@neicon.ruФГБУ Учебно-научный медицинский центр Управления делами Президента Российской ФедерацииРоссия2014231220221136874Copyright © Барышникова Г.А., Степанова И.И., Кудрявцева Н.А., 20222022Барышникова Г.А., Степанова И.И., Кудрявцева Н.А.Baryshnikov G.A., Stepanova I.I., Kudryavtseva N.A.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.syst-hypertension.ru/jour/article/view/370

В статье представлены данные о терапевтической эффективности b-адреноблокаторов при ишемической болезни сердца, хронической сердечной недостаточности, артериальной гипертонии. Рассмотрены основные механизмы фармакологического действия препаратов этого класса. В сравнении с другими b-адреноблокаторами обсуждаются фармакодинамическиеи фармакокинетические особенности метопролола сукцината пролонгированного действия, его преимущества перед короткодействующими препаратами, его влияние на течение хронической сердечной недостаточности. На основании результатов рандомизированных клинических исследований сделан вывод о высокой терапевтической эффективности и безопасности метопролола сукцината с пролонгированным действием.

This article presents the data on the therapeutic efficacy ofbeta-adrenergic blocking agentsin ischemic heart disease, chronic heart failure (CHF), arterial hypertension. We analyzed the basic pharmacological mechanism of action of these drugs class. The comparison of pharmacodynamic and pharmacokinetic characteristics of metoprolol succinate retard with other beta-adrenoreceptor-blocking agents showed metoprolol succinate advantage over the short-term drugs for treatment of CHF. According to the results of randomised clinical trialswe determined high therapeutic efficacy and safety of metoprolol succinate retard.

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The authors declare that there are no conflicts of interest present.