systhiperСистемные гипертензииSystemic Hypertension2075-082X2542-2189LLC «ИнтерМедсервис»systhiper-372Research ArticleОБЗОРЫПлейотропные свойства дигидропиридиновых антагонистов кальциевых каналов‌‌Pleiotropic features of dihydropyridine calcium channel antagonistsАникинГ. С.AnikinG. S.noemail@neicon.ruГБОУ ВПО Первый Московский государственный медицинский университет им. И.М.Сеченова Минздрава России; ФГБУ Поликлиника №3 Управления делами Президента Российской ФедерацииRussian Federation2014231220221138183Copyright © Аникин Г.С., 20222022Аникин Г.С.Anikin G.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.syst-hypertension.ru/jour/article/view/372

Современную медицину трудно представить без надежных и безопасных лекарственных средств. Зачастую нежелательные лекарственные реакции являются поводом для отмены средства, которое в целом эффективно. Так, у дигидропиридиновых блокаторов кальциевых каналов основными нежелательными лекарственными реакциями, служащими поводом для отмены данных препаратов, являются отеки голеней и тахикардия. Лерканидипин - относительно новый представитель данного класса, представляет собой высоколипофильное соединение, которое долго ингибирует кальциевые каналы L-типа благодаря сохранению высокой внутримембранной концентрации. В обзоре представлены данные об эффективности и безопасности лерканидипина,а также о его плейотропных свойствах.

It is hard to imagine modern medicine without safe drugs (D). Often, adverse drug reactions (ADR) are the reason for drug with drawal, which is quite effective as a whole. The main dihydropyridine calcium channel antagonists (DCCA) ADR are the edema of shin and tachycardia, causing this drug with drawal. Lercanidipine is aquite new member of this class; it is a highly lipophilic compound, which blocking the influx of calcium ions through L-type calcium channels, by maintaining the high intramembrane concentration. This review provides the data on the efficacy and safety of lercanidipine and its pleiotropic features.

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The authors declare that there are no conflicts of interest present.