References

systhiper

Системные гипертензии

Systemic Hypertension

2075-082X2542-2189

LLC «ИнтерМедсервис»

systhiper-417

Research Article

КАРДИОЛОГИЯ / CARDIOLOGY

Жесткость сосудистой стенки у пациентов с артериальной гипертонией

The hardness of the vessel wall in patients with arterial hypertension

Остроумова

О. Д.

Ostroumova

O. D.

ostroumova.olga@mail.ru

Кочетков

А. И.

Kochetkov

A. I.

ak_info@list.ru

Копченов

И. И.

Kopchenov

I. I.

iik976@mail.ru

Гусева

Т. Ф.

Guseva

T. F.

noemail@neicon.ru

Бондарец

О. В.

Bondarec

O. V.

noemail@neicon.ru

ГБОУ ВПО Московский государственный медико-стоматологический университет им. А.И.Евдокимова Минздрава России; ГБОУ ВПО Первый Московский государственный медицинский университет им. И.М.Сеченова Минздрава РоссииРоссияA.I.Evdokimov Moscow State Medical and Dental University of the Ministry of Health of the Russian Federation; I.M.Sechenov First Moscow State Medical University of the Ministry of Health of the Russian FederationRussian Federation

ГБОУ ВПО Московский государственный медико-стоматологический университет им. А.И.Евдокимова Минздрава РоссииРоссияA.I.Evdokimov Moscow State Medical and Dental University of the Ministry of Health of the Russian FederationRussian Federation

2015

23122022

1224348

2022

Остроумова О.Д., Кочетков А.И., Копченов И.И., Гусева Т.Ф., Бондарец О.В.

Ostroumova O.D., Kochetkov A.I., Kopchenov I.I., Guseva T.F., Bondarec O.V.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://www.syst-hypertension.ru/jour/article/view/417

В статье рассмотрена роль жесткости сосудистой стенки в патогенезе артериальной гипертонии, ее осложнений и сердечно-сосудистой смертности. Обсуждаются факторы, повышающие жесткость сосудистой стенки, - возраст, уровень артериального давления, атеросклероз, курение, сахарный диабет. Приведены показатели, которые отражают состояние сосудистой стенки и являются маркерами повышенного риска развития сердечно-сосудистых осложнений. Рассмотрены данные об улучшении параметров, характеризующих жесткость сосудистой стенки под влиянием антигипертензивной терапии блокатором рецепторов ангиотензина II 1-го типа кандесартаном. Обсуждаются возможные механизмы влияния кандесартана на эластические свойства сосудов. Подчеркивается, что эффект антигипертензивных медикаментов, даже относящихся к одному классу, на жесткость артерий разный, что, по-видимому, обусловлено различием в фармакокинетических свойствах.

The article deals with the role of the hardness of the vessel wall in the pathogenesis of arterial hypertension and its complications and cardiovascular mortality. We discussed the factors increasing the hardness of the vessel wall, such as age, blood pressure level, atherosclerosis, smoking and diabetes mellitus. We showed the indicators reflecting the status of the vascular wall and which could play a role of markers of increased risk of cardiovascular complications. We reviewed the data concerning the improvement of the parameters of the hardness of the vessel wall under the influence of antihypertensive therapy using the angiotensin II type 1 receptor blocker - candesartan. We discussed the possible mechanisms of the candesartan influence on the elastic properties of the vessels. We stressed that the effect on the hardness of the arteries on using antihypertensive drugs, even within the same class, was different, which, apparently, was associated with the difference in the pharmacokinetic properties.

артериальная гипертониясахарный диабетжесткость сосудистой стенкискорость пульсовой волныблокаторы рецепто- ров ангиотензина IIкандесартан

arterial hypertensiondiabetes mellitusthe hardness of the vessel wallpulse ware velocityangiotensin II receptor blockerscan- desartan

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The authors declare that there are no conflicts of interest present.