References

systhiper

Системные гипертензии

Systemic Hypertension

2075-082X2542-2189

LLC «ИнтерМедсервис»

systhiper-418

Research Article

АНТИГИПЕРТЕНЗИВНАЯ ТЕРАПИЯ / ANTIHYPERTENSIVE THERAPY

Блокаторы кальциевых каналов: более 50 лет на страже здоровья

Calcium channel blockers: more than 50 years on guard of health

Чазова

И. Е.

Chazova

I. E.

noemail@neicon.ru

Жернакова

Ю. В.

Zhernakova

Yu. V.

juli001@mail.ru

Институт клинической кардиологии им. А.Л.Мясникова ФГБУ Российский кардиологический научно-производственный комплекс Минздрава РоссииРоссияA.L.Myasnikov Institute of Clinical Cardiology, Russian Cardiological Scientific-Industrial Complex of the Ministry of Health of the Russian FederationRussian Federation

2015

23122022

1224956

2022

Чазова И.Е., Жернакова Ю.В.

Chazova I.E., Zhernakova Y.V.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://www.syst-hypertension.ru/jour/article/view/418

Класс препаратов антагонисты кальция (АК), или блокаторы кальциевых каналов (БКК), объединяет в себе довольно разнородную группу лекарственных средств, обладающих общими вазодилатирующими свойствами за счет снижения тока кальция через гладкомышечные клетки сосудистой стенки и вместе с тем разной степенью влияния на сердечную мышцу, функцию синусового узла, атриовентрикулярную проводимость, тонус периферических сосудов и коронарное кровоснабжение. Появление лекарственных препаратов этого класса стало одним из великих достижений в области фармакологии в конце XX в. Особое место в гипертензиологии занимают БКК III поколения, обладающие высокой биодоступностью и тканевой селективностью. Современные пролонгированные АК широко применяются при артериальной гипертонии (АГ), особенно актуальны они у пациентов с сахарным диабетом, заболеваниями периферических артерий, хронической обструктивной болезнью легких и бронхиальной астмой, ишемической болезнью сердца, у больных пожилого возраста с систолической АГ. Эти препараты обладают не только выраженным антигипертензивным действием, органопротективными свойствами, но и способны улучшать прогноз у пациентов высокого и очень высокого кардиоваскулярного риска.

The class of drugs - calcium antagonists (CA), or calcium channel blockers (CCBs) is combined a quite heterogeneous drugs group possessing common vasodilatatory characteristics by disruption of the movement of calcium through the vascular smooth muscle cells and with different degree of impact on myocardium, the sinus node function, atrioventricular conduction, tonus of peripheral vessels and coronary blood flow. The existence of this class of drugs has become one of the great achievements in the field of pharmacology, at the end of the 20th century. Third Generation CCBs takes the special place in hypertensiology because of high bioavailability and tissue selectivity. Modern long-acting CA are widely used in case of arterial hypertension (AH), they can be used especially in patients with diabetes mellitus, peripheral artery disease, chronic obstructive pulmonary disease and bronchial asthma, ischemic heart disease and in elderly patients with systolic AH. These drugs show not only antihypertensive effect and organoprotective characteristics, but also can improve the prognosis in patients with high and very high cardiovascular risk.

артериальная гипертонияантигипертензивная терапияблокаторы кальциевых каналов

arterial hypertensionantihypertensive therapycalcium channel blockers

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The authors declare that there are no conflicts of interest present.