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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">systhiper</journal-id><journal-title-group><journal-title xml:lang="ru">Системные гипертензии</journal-title><trans-title-group xml:lang="en"><trans-title>Systemic Hypertension</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2075-082X</issn><issn pub-type="epub">2542-2189</issn><publisher><publisher-name>LLC «ИнтерМедсервис»</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">systhiper-424</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ / REVIEWS</subject></subj-group></article-categories><title-group><article-title>Ограничение калорийности пищи -ключ к профилактике сосудистого старения</article-title><trans-title-group xml:lang="en"><trans-title>Restriction of caloric intake is a key to prevention of vascular ageing</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Орлова</surname><given-names>Я. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Orlova</surname><given-names>Ya. A.</given-names></name></name-alternatives><email xlink:type="simple">orlova@cardio.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБОУ ВПО Московский государственный университет им. М.В.Ломоносова</institution><country>Россия</country></aff><aff xml:lang="en"><institution>M.V.Lomonosov Moscow State University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2015</year></pub-date><pub-date pub-type="epub"><day>23</day><month>12</month><year>2022</year></pub-date><volume>12</volume><issue>2</issue><fpage>89</fpage><lpage>95</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Орлова Я.А., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Орлова Я.А.</copyright-holder><copyright-holder xml:lang="en">Orlova Y.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.syst-hypertension.ru/jour/article/view/424">https://www.syst-hypertension.ru/jour/article/view/424</self-uri><abstract><p>Исследования последних десятилетий позволяют предположить, что замедление процессов старения в настоящее время является реалистичной целью. Описан целый ряд физиологических процессов, которые могут повлиять на смертность и связанное с возрастом ухудшение функционального состояния. Одним из наиболее изученных воздействий является ограничение калорийности пищи (ОКП), которое предполагает снижение ежедневного потребления калорий на 30-50% по сравнению с неограниченным приемом пищи. Показаны эффекты ОКП на суммарный риск развития сердечно-сосудистых заболеваний, на разные биомаркеры старения у людей без ожирения, на артериальное давление и др.</p></abstract><trans-abstract xml:lang="en"><p>Studies in recent decades suggest that slowing down the aging process is now real. We describe a number of physiological processes, which may affect the mortality and age-related deterioration of the functional state. One of the most studied impact is to limit caloric intake, which implies a decrease in daily caloric intake by 30-50% compared with an unlimited meal.Showing the effects of GST on the total risk of developing cardiovascular disease, different biomarkers of aging in people without obesity, blood pressure, and others.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>ограничение калорийности пищи</kwd><kwd>сосудистое старение</kwd><kwd>профилактика</kwd><kwd>сиртуины</kwd><kwd>небиволол</kwd></kwd-group><kwd-group xml:lang="en"><kwd>caloric restriction</kwd><kwd>vascular aging</kwd><kwd>prevention</kwd><kwd>sirtuins</kwd><kwd>nebivolol</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">World Population Prospects: The 2008 Revision Population Division of the Department of Economic and Social Affairs of the United Nations Secretariat. 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