systhiperСистемные гипертензииSystemic Hypertension2075-082X2542-2189LLC «ИнтерМедсервис»systhiper-459Research ArticleКАРДИОЛОГИЯCARDIOLOGYСосудистая жесткость у больных артериальной гипертензией: возможности антигипертензивной терапииVascular stiffness in patients with arterial hypertension: possible antihypertensive therapyОстроумоваО. Д.OstroumovaO. D.ostroumova.olga@mail.ruКочетковА. И.KochetkovA. I.ak_info@list.ruЛопухинаМ. В.LopukhinaM. V.ofd70@mail.ruГБОУ ВПО Московский государственный медико-стоматологический университет им. А.И.Евдокимова Минздрава России; ГБОУ ВПО Первый Московский государственный медицинский университет им. И.М.Сеченова Минздрава РоссииРоссияA.I.Evdokimov Moscow State Medical and Dental University of the Ministry of Health of the Russian Federation; I.M.Sechenov First Moscow State Medical University of the Ministry of Health of the Russian FederationRussian FederationГБОУ ВПО Московский государственный медико-стоматологический университет им. А.И.Евдокимова Минздрава РоссииРоссияA.I.Evdokimov Moscow State Medical and Dental University of the Ministry of Health of the Russian FederationRussian FederationГБУЗ Городская клиническая больница им. Е.О.Мухина Департамента здравоохранения МосквыРоссияE.O.Mukhin City Clinical Hospital of the Department of Health of MoscowRussian Federation2016231220221321723Copyright © Остроумова О.Д., Кочетков А.И., Лопухина М.В., 20222022Остроумова О.Д., Кочетков А.И., Лопухина М.В.Ostroumova O.D., Kochetkov A.I., Lopukhina M.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.syst-hypertension.ru/jour/article/view/459

В статье обсуждаются факторы, повышающие жесткость сосудистой стенки: уровень артериального давления, атеросклероз, курение, сахарный диабет, возраст. Приведены данные о том, что скорость пульсовой волны и ряд других показателей, которые отражают состояние сосудистой стенки, являются маркерами повышенного риска развития сердечно-сосудистых осложнений и смертности. Рассмотрено влияние антигипертензивных препаратов разных групп на жесткость сосудистой стенки, особое внимание уделено эффектам лекарственных средств из группы диуретиков. Обсуждаются возможные механизмы влияния индапамида ретард на эластические свойства сосудов. Подчеркивается, что влияние на жесткость артерий разных антигипертезивных медикаментов, даже относящихся к одному классу, отличается, что обусловлено различием в фармакокинетических свойствах.

The article discusses the factors that increase the arterial stiffness: the blood pressure, atherosclerosis, smoking, diabetes, age. Given evidence that pulse wave velocity and a number of other indicators that reflect the state of the vascular wall, are markers for increased risk of cardiovascular complications and mortality. The influence of antihypertensive drugs of different groups on the stiffness of the vascular wall, with particular attention paid to the effects of drugs from group of diuretics. We discuss possible mechanisms of the influence of indapamide retard on the elastic properties of vessels. It is emphasized that the influence on the stiffness of the arteries of different antigipertenzivny medicines, even belong to the same class, is different, due to differences in pharmacokinetic properties.

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The authors declare that there are no conflicts of interest present.