systhiperСистемные гипертензииSystemic Hypertension2075-082X2542-2189LLC «ИнтерМедсервис»systhiper-477Research ArticleМЕТАБОЛИЧЕСКИЕ НАРУШЕНИЯMETABOLIC DISTURBANCESЭтногенетические аспекты ожирения и нарушений углеводного обмена как факторов риска артериальной гипертензииEthnogenetic aspects of obesity and disorders of carbohydrate metabolism as a risk factor of arterial hypertensionМулероваТ. А.MulerovaT. A.mulerova-77@mail.ruЦыганковаД. П.TsygankovaD. P.noemail@neicon.ruВоропаеваЕ. Н.VoropaevaE. N.noemail@neicon.ruМаксимовВ. Н.MaksimovV. N.noemail@neicon.ruОгарковМ. Ю.OgarkovM. Yu.noemail@neicon.ruФГБНУ НИИ комплексных проблем сердечно-сосудистых заболеваний; ГБОУ ДПО Новокузнецкий государственный институт усовершенствования врачей Минздрава РоссииРоссияResearch Institute for Complex Issues of Cardiovascular Diseases; Novokuznetsk State Institute of Postgraduate Medicine of the Ministry of Health of the Russian FederationRussian FederationФГБНУ НИИ комплексных проблем сердечно-сосудистых заболеванийРоссияResearch Institute for Complex Issues of Cardiovascular DiseasesRussian FederationФГБНУ НИИ терапии и профилактической медициныРоссияInstitution of Internal and Preventive MedicineRussian Federation2016231220221334857Copyright © Мулерова Т.А., Цыганкова Д.П., Воропаева Е.Н., Максимов В.Н., Огарков М.Ю., 20222022Мулерова Т.А., Цыганкова Д.П., Воропаева Е.Н., Максимов В.Н., Огарков М.Ю.Mulerova T.A., Tsygankova D.P., Voropaeva E.N., Maksimov V.N., Ogarkov M.Y.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.syst-hypertension.ru/jour/article/view/477

Цель - изучить ассоциации генов-кандидатов артериальной гипертензии (АГ): ACE, ADRA2B, ADRB1, MTHFR и eNOS - с ожирением и нарушениями углеводного обмена с учетом этнической принадлежности. Материал и методы. Проведено клинико-эпидемиологическое исследование компактно проживающего населения в труднодоступных районах Горной Шории (п. Ортон, п. Усть-Кабырза, п. Шерегеш Кемеровской области). Сплошным методом обследованы 1178 жителей указанных поселков, выборка состояла из взрослого населения (18 лет и старше). Результаты. В группе респондентов коренной национальности средние величины индекса Кетле, окружности талии и глюкозы крови натощак в зависимости от полиморфизма генов-кандидатов АГ - ACE, ADRA2B, ADRB1, MTHFR и eNOS - оказались ниже, чем в группе обследованных некоренного этноса. В популяции шорцев была выявлена статистически значимая взаимосвязь индекса Кетле с генотипами гена AСЕ, в популяции некоренных представителей - с генотипами гена ADRA2B. В группе коренного этноса выявлена взаимосвязь окружности талии с полиморфизмом гена АСЕ. Независимо от национальной принадлежности выявлена ассоциативная связь данного показателя с полиморфизмом гена ADRA2B. Уровень глюкозы плазмы в популяции некоренного этноса был взаимосвязан с генотипами гена ADRA2B. Заключение. Метаболические нарушения были выявлены реже в коренной этнической группе по сравнению с представителями некоренной национальности. В группе шорцев генотипы DD генов АСЕ и ADRA2B ассоциировались с ожирением, генотип 4а/4а гена eNOS - с абдоминальным ожирением. В группе некоренного этноса генотип СС гена MTHFR ассоциировался с абдоминальным ожирением, генотипы II гена АСЕ и DD гена ADRA2B - с нарушениями углеводного обмена.

Objective - to explore the association of candidate genes of arterial hypertension ACE, ADRA2B, ADRB1, MTHFR and eNOS with obesity and impaired glucose metabolism based on ethnicity. Materials and methods. Clinical and epidemiological study of compactly living population in the remote areas of the Mountain Shoria (Orton, Ust-Kabyrza, Sheregesh settlements, Kemerovo region). 1178 residents of these settlements were surveyed with the help of continuous sampling method; the sample consisted of adults (18 years and older). Results. In the group of respondents of the indigenous nationality averages Quetelet index, waist circumference and fasting blood glucose, depending on the polymorphism of candidate genes of arterial hypertension ACE, ADRA2B, ADRB1, MTHFR and eNOS were lower than in non-indigenous ethnic group surveyed. In a population of Shor was found a statistically significant relationship with the body mass index of ACE gene genotypes in a population of non-indigenous representatives - with genotypes of ADRA2B gene. In the group of indigenous ethnic group revealed the relationship from ACE gene polymorphism. Regardless of nationality, found associative connection of the indicator polymorphism of ADRA2B gene. The level of plasma glucose levels in a population of non-indigenous ethnic group was correlated with genotypes of ADRA2B gene. Conclusion. Metabolic abnormalities were detected less frequently in indigenous ethnic group compared with the non-indigenous. In Shor group ACE DD genotype and ADRA2B genes associated with obesity, the genotype 4a/4a eNOS gene - with abdominal obesity. In the group of non-indigenous ethnic group CC genotype of the MTHFR gene was associated with abdominal obesity, II genotype of ACE gene and DD ADRA2B gene - with impaired carbohydrate metabolism.

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The authors declare that there are no conflicts of interest present.