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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">systhiper</journal-id><journal-title-group><journal-title xml:lang="ru">Системные гипертензии</journal-title><trans-title-group xml:lang="en"><trans-title>Systemic Hypertension</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2075-082X</issn><issn pub-type="epub">2542-2189</issn><publisher><publisher-name>LLC «ИнтерМедсервис»</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">systhiper-479</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ</subject></subj-group></article-categories><title-group><article-title>Верапамил замедленного высвобождения: возможности применения в клинической практике</article-title><trans-title-group xml:lang="en"><trans-title>Prolonged release verapamil: application in clinical practice</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гапонова</surname><given-names>Н. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Gaponova</surname><given-names>N. I.</given-names></name></name-alternatives><email xlink:type="simple">nade-gaponova@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Абдрахманов</surname><given-names>В. Р.</given-names></name><name name-style="western" xml:lang="en"><surname>Abdrakhmanov</surname><given-names>V. R.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">ФГБОУ ВО Московский государственный медико-стоматологический университет им. А.И.Евдокимова Минздрава России<country>Россия</country></aff><aff xml:lang="en">A.I.Evdokimov Moscow State University of Medicine and Dentistry of the Ministry of Health of the Russian Federation<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2016</year></pub-date><pub-date pub-type="epub"><day>23</day><month>12</month><year>2022</year></pub-date><volume>13</volume><issue>3</issue><fpage>64</fpage><lpage>68</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Гапонова Н.И., Абдрахманов В.Р., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Гапонова Н.И., Абдрахманов В.Р.</copyright-holder><copyright-holder xml:lang="en">Gaponova N.I., Abdrakhmanov V.R.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.syst-hypertension.ru/jour/article/view/479">https://www.syst-hypertension.ru/jour/article/view/479</self-uri><abstract><p>В обзоре отражены результаты применения верапамила (препарат Изоптин® СР) пролонгированного действия в клинической практике. Многочисленные рандомизированные клинические исследования подтверждают высокую эффективность и безопасность применения препарата Изоптин® СР при артериальной гипертонии, а также у пациентов с артериальной гипертонией в сочетании с ишемической болезнью сердца, хроническими обструктивными заболеваниями легких, нарушениями углеводного и липидного обмена. Доказано преимущество применения препарата Изоптин® СР (верапамил) при наджелудочковых нарушениях сердечного ритма.</p></abstract><trans-abstract xml:lang="en"><p>The review shows the results of the use of prolonged release verapamil (Isoptin® SR) in clinical practice. Numerous randomized clinical studies confirm the high efficiency and safety of Isoptin® SR in patients with arterial hypertension, as well as in patients with arterial hypertension in combination with ischaemic heart disease, chronic obstructive pulmonary diseasesand disorders of carbohydrate and lipid metabolism. The advantage of Isoptin® SR (verapamil) application in case of supraventricular arrhythmias has been proven.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>артериальная гипертония</kwd><kwd>блокаторы кальциевых каналов</kwd><kwd>верапамил</kwd><kwd>Изоптин® СР замедленного высвобождения</kwd></kwd-group><kwd-group xml:lang="en"><kwd>arterial hypertension</kwd><kwd>calcium channel blockers</kwd><kwd>verapamil</kwd><kwd>Isoptin® SR prolonged-release tablets</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Чазова И.Е., Жернакова Ю.В. Блокаторы кальциевых каналов: более 50 лет на страже здоровья//Системные гипертензии. 2015; 12 (12): 49-56.</mixed-citation><mixed-citation xml:lang="en">Чазова И.Е., Жернакова Ю.В. Блокаторы кальциевых каналов: более 50 лет на страже здоровья//Системные гипертензии. 2015; 12 (12): 49-56.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Furberg C.D, Psaty B.M, Meyer J.V. Nifedipine: Dose - related increase in mortality in patients with coronary heart disease. Circulation 1995; 92 (5): 1326-31.</mixed-citation><mixed-citation xml:lang="en">Furberg C.D, Psaty B.M, Meyer J.V. Nifedipine: Dose - related increase in mortality in patients with coronary heart disease. Circulation 1995; 92 (5): 1326-31.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Lee S.H, Yu W.C, Cheng J.J et al. Effect of verapamil on long - term tachycardia - induced atrial electrical remodeling. Circulation 2000; 101: 200-6.</mixed-citation><mixed-citation xml:lang="en">Lee S.H, Yu W.C, Cheng J.J et al. Effect of verapamil on long - term tachycardia - induced atrial electrical remodeling. Circulation 2000; 101: 200-6.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Leistad E, Alknes G, Verburg E et al. Atrial contractile dysfunction after short - term atrial fibrillation is reduced by verapamil but increased by BAY K 8644. Circulation 1996; 93: 1736-54.</mixed-citation><mixed-citation xml:lang="en">Leistad E, Alknes G, Verburg E et al. Atrial contractile dysfunction after short - term atrial fibrillation is reduced by verapamil but increased by BAY K 8644. Circulation 1996; 93: 1736-54.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Lefrandt J.D, Heitmann J, Sevre K et al. The effects of dihydropyridine and phenylalkylamine calcium antagonist classes on autonomic function in hypertension: the VAMPHYRE study. Am J Hypertens 2001; 14: 1083-9.</mixed-citation><mixed-citation xml:lang="en">Lefrandt J.D, Heitmann J, Sevre K et al. The effects of dihydropyridine and phenylalkylamine calcium antagonist classes on autonomic function in hypertension: the VAMPHYRE study. Am J Hypertens 2001; 14: 1083-9.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Harris D.C.H, Hammond W.S, Bure T.J et al. Verapamil protects against progression of experimental chronic renal failure. Kidney Int 1987; 31: 41-6.</mixed-citation><mixed-citation xml:lang="en">Harris D.C.H, Hammond W.S, Bure T.J et al. Verapamil protects against progression of experimental chronic renal failure. Kidney Int 1987; 31: 41-6.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Bacris G.Z, Copley J.B, Vicknair N et al. Verapamil SR has similar nephroprotective properties to lisinopril and is significantly better in comparison to atenolol. Kidney International 1996; 50: 1641-59.</mixed-citation><mixed-citation xml:lang="en">Bacris G.Z, Copley J.B, Vicknair N et al. Verapamil SR has similar nephroprotective properties to lisinopril and is significantly better in comparison to atenolol. Kidney International 1996; 50: 1641-59.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Stadler P, Leonardi L, Riesen W et al. Cardiovascular effects of verapamil in essential hypertension. Clin Pharmacol Ther 1987; 42: 485-92.</mixed-citation><mixed-citation xml:lang="en">Stadler P, Leonardi L, Riesen W et al. Cardiovascular effects of verapamil in essential hypertension. Clin Pharmacol Ther 1987; 42: 485-92.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Speders S, Sosna J, Schumacher A et al. Efficacy and tolerability of Isoptin SR in essential hypertension. Hochdruck 1988; 8: 3-14.</mixed-citation><mixed-citation xml:lang="en">Speders S, Sosna J, Schumacher A et al. Efficacy and tolerability of Isoptin SR in essential hypertension. Hochdruck 1988; 8: 3-14.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">EVEREST’H - Evaluation of Verapamil for Efficacy, Safety and Tolerability in the management of Hypertension. Multicentre trial of the antihypertensive efficacy and safety of Verapamil SR. Act Med Int 1990; 2: 3-7.</mixed-citation><mixed-citation xml:lang="en">EVEREST’H - Evaluation of Verapamil for Efficacy, Safety and Tolerability in the management of Hypertension. Multicentre trial of the antihypertensive efficacy and safety of Verapamil SR. Act Med Int 1990; 2: 3-7.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Кукес В.Г., Красных Л.М., Теплоногова Е.В. Применение Изоптина SR в лечении артериальной гипертонии. Клин. фармакология и терапия. 1999; 8: 51-2.</mixed-citation><mixed-citation xml:lang="en">Кукес В.Г., Красных Л.М., Теплоногова Е.В. Применение Изоптина SR в лечении артериальной гипертонии. Клин. фармакология и терапия. 1999; 8: 51-2.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Grossman E, Messerli F.H. Effect of calcium antagonists on plasma norepinerhrine levels, heart rate and blood pressure. Am J Cardiol 1997; 80: 1453-8.</mixed-citation><mixed-citation xml:lang="en">Grossman E, Messerli F.H. Effect of calcium antagonists on plasma norepinerhrine levels, heart rate and blood pressure. Am J Cardiol 1997; 80: 1453-8.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Zachariah P, Sheps S, Oshrain C et al. Antihypertensive efficacy of sustained - release verapamil. J Clin Hypertens 1987; 3: 536-46.</mixed-citation><mixed-citation xml:lang="en">Zachariah P, Sheps S, Oshrain C et al. Antihypertensive efficacy of sustained - release verapamil. J Clin Hypertens 1987; 3: 536-46.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Speders S, Sosna J, Schumacher A et al. Efficacy and safety of verapamil SR 240 mg in essential hypertension: results of a multicentric phase IV study. J Cardiovasc Pharmacol 1989; 13 (Suppl. 4): S.47-S.49.</mixed-citation><mixed-citation xml:lang="en">Speders S, Sosna J, Schumacher A et al. Efficacy and safety of verapamil SR 240 mg in essential hypertension: results of a multicentric phase IV study. J Cardiovasc Pharmacol 1989; 13 (Suppl. 4): S.47-S.49.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Cummings J.M, Amadlio P, Nelson L. The role of calcium channel blocker in the treatment of essential hypertension. Arch Intern Med 1991; 151: 250-9.</mixed-citation><mixed-citation xml:lang="en">Cummings J.M, Amadlio P, Nelson L. The role of calcium channel blocker in the treatment of essential hypertension. Arch Intern Med 1991; 151: 250-9.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Маколкин В.И. Изоптин СР 240 - эффективный антигипертензивный и антиишемический препарат. Артериальная гипертензия. 2006; 3: 233-6.</mixed-citation><mixed-citation xml:lang="en">Маколкин В.И. Изоптин СР 240 - эффективный антигипертензивный и антиишемический препарат. Артериальная гипертензия. 2006; 3: 233-6.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Hla K, Henry J, Latham A. Pharmacokinetics and pharmacodynamics of two formulations of verapamil. Br J Clin Pharmacol 1987; 24: 661-4.</mixed-citation><mixed-citation xml:lang="en">Hla K, Henry J, Latham A. Pharmacokinetics and pharmacodynamics of two formulations of verapamil. Br J Clin Pharmacol 1987; 24: 661-4.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Weinberger M.H. The relationship of sodium balance and concomitant diuretic therapy to blood pressure response with calcium channel entry blockers. Am J Med 1991; 90 (Suppl. 5A): S.15-S.20.</mixed-citation><mixed-citation xml:lang="en">Weinberger M.H. The relationship of sodium balance and concomitant diuretic therapy to blood pressure response with calcium channel entry blockers. Am J Med 1991; 90 (Suppl. 5A): S.15-S.20.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Weir M, Lavin P. Comparison of the efficacy and tolerability of lisinopril and sustained - release verapamil in older patients with hypertension. Clin Ther 1991; 13 (3): 401-8.</mixed-citation><mixed-citation xml:lang="en">Weir M, Lavin P. Comparison of the efficacy and tolerability of lisinopril and sustained - release verapamil in older patients with hypertension. Clin Ther 1991; 13 (3): 401-8.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Rubio-Guerra A.F, Vargas-Robles H, Vargas-Ayala G et al. The effect of trandolapril and its fixed - dose combination with verapamil on circulating adhesion molecules levels in hypertensive patients with type 2 diabetes. Clin Exp Hypertens 2008; 30 (7): 685-8.</mixed-citation><mixed-citation xml:lang="en">Rubio-Guerra A.F, Vargas-Robles H, Vargas-Ayala G et al. The effect of trandolapril and its fixed - dose combination with verapamil on circulating adhesion molecules levels in hypertensive patients with type 2 diabetes. Clin Exp Hypertens 2008; 30 (7): 685-8.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Манукян А.В., Сидоренкова Н.Б., Лаврентьев А.В. Влияние пролонгированных антагонистов кальция на циркадианный и ультрадианный ритмы артериального давления больных с артериальной гипертонией высокого риска. Фармакология. 2006; 7 (9): 228-35.</mixed-citation><mixed-citation xml:lang="en">Манукян А.В., Сидоренкова Н.Б., Лаврентьев А.В. Влияние пролонгированных антагонистов кальция на циркадианный и ультрадианный ритмы артериального давления больных с артериальной гипертонией высокого риска. Фармакология. 2006; 7 (9): 228-35.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Schmieder R.E, Messerli F.H, Garavaglia G.E et al. Cardiovascular effects of verapamil in patients with essential hypertension. Circulation 1987; 75 (5): 1030-6.</mixed-citation><mixed-citation xml:lang="en">Schmieder R.E, Messerli F.H, Garavaglia G.E et al. Cardiovascular effects of verapamil in patients with essential hypertension. Circulation 1987; 75 (5): 1030-6.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Granier P, Douste-Blazy M, Tredez P et al. Improvement in left ventricular hypertrophy and left ventricular diastolic function following verapamil therapy in mild to moderate hypertension. Eur J Clin Pharmacol 1990; 39 (Suppl. 1): S.45- S.46.</mixed-citation><mixed-citation xml:lang="en">Granier P, Douste-Blazy M, Tredez P et al. Improvement in left ventricular hypertrophy and left ventricular diastolic function following verapamil therapy in mild to moderate hypertension. Eur J Clin Pharmacol 1990; 39 (Suppl. 1): S.45- S.46.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Van Merode T, Van Bortel L, Smeets F.A et al. The effect of verapamil on carotid artery distensability and cross - sectional compliance in hypertensive patients. J Cardiovase Pharmacol 1990; 1: 109-13.</mixed-citation><mixed-citation xml:lang="en">Van Merode T, Van Bortel L, Smeets F.A et al. The effect of verapamil on carotid artery distensability and cross - sectional compliance in hypertensive patients. J Cardiovase Pharmacol 1990; 1: 109-13.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Breithaupt-Grogler K, Gerhardt G, Lehmann G et al. Blood pressure and aortic elasic properties - verapamil SR/trandolapril compared a metoprolol/hydrochlorothiazide combination therapy. Int J Clin Pharm Ther 1998; 36: 425-31.</mixed-citation><mixed-citation xml:lang="en">Breithaupt-Grogler K, Gerhardt G, Lehmann G et al. Blood pressure and aortic elasic properties - verapamil SR/trandolapril compared a metoprolol/hydrochlorothiazide combination therapy. Int J Clin Pharm Ther 1998; 36: 425-31.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Ferrari R, Cuchtnt K, Bobgneti R et al. How do calcium antagonists differ in clinical practice? Cardiovasc Drug Therapy 1994; 8 (Suppl. 3): S.566-S.575.</mixed-citation><mixed-citation xml:lang="en">Ferrari R, Cuchtnt K, Bobgneti R et al. How do calcium antagonists differ in clinical practice? Cardiovasc Drug Therapy 1994; 8 (Suppl. 3): S.566-S.575.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Pepine C, Handberg E, Cooper-De-Hoff R et al. A calcium antagonist vs a non - calcium antagonist hypertension treatment strategy for patients with coronary artery disease. The International Verapamil - Trandolapril Study (INVEST): A Randomized Controlled Trial. JAMA 2003; 290: 2805-16.</mixed-citation><mixed-citation xml:lang="en">Pepine C, Handberg E, Cooper-De-Hoff R et al. A calcium antagonist vs a non - calcium antagonist hypertension treatment strategy for patients with coronary artery disease. The International Verapamil - Trandolapril Study (INVEST): A Randomized Controlled Trial. JAMA 2003; 290: 2805-16.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Pallone N.M. Effect of calcium antagonists in the treatment of silent ischemic heart disease. Curr Ther Res 1989; 45: 339-46.</mixed-citation><mixed-citation xml:lang="en">Pallone N.M. Effect of calcium antagonists in the treatment of silent ischemic heart disease. Curr Ther Res 1989; 45: 339-46.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Rehnqvist N, Hjemdahl P, Billing E et al. Effect of metoprolol vs verapamil in patients with stable angina pectoris. The Angina Prognosis Study in Stockholm (APSIS). Eur Heart J 1996; 17: 76-81.</mixed-citation><mixed-citation xml:lang="en">Rehnqvist N, Hjemdahl P, Billing E et al. Effect of metoprolol vs verapamil in patients with stable angina pectoris. The Angina Prognosis Study in Stockholm (APSIS). Eur Heart J 1996; 17: 76-81.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">The Danish Verapamil Infarction Trial II - DAVIT II: Effect of verapamil on mortality and maior events after acute myocardial infarction. Am J Cardiol 1990; 66: 331-401.</mixed-citation><mixed-citation xml:lang="en">The Danish Verapamil Infarction Trial II - DAVIT II: Effect of verapamil on mortality and maior events after acute myocardial infarction. Am J Cardiol 1990; 66: 331-401.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Rengo F, Carbonin P, Pahor M et al. A controlled Trial of verapamil inpatients after acute myocardial infarction: results of the Calcium Antagonist Reinfarction Italian Study (CRIS). Am J Cardiol 1996; 77: 365-9.</mixed-citation><mixed-citation xml:lang="en">Rengo F, Carbonin P, Pahor M et al. A controlled Trial of verapamil inpatients after acute myocardial infarction: results of the Calcium Antagonist Reinfarction Italian Study (CRIS). Am J Cardiol 1996; 77: 365-9.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Hoberg E, Dietz R, Frees U et al. Verapamil treatment after coronary angioplasty in patients at high risk of recurrent stenosis. Br Heart J 1994; 71: 254-60.</mixed-citation><mixed-citation xml:lang="en">Hoberg E, Dietz R, Frees U et al. Verapamil treatment after coronary angioplasty in patients at high risk of recurrent stenosis. Br Heart J 1994; 71: 254-60.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Задионченко В.С., Адашева Т.В., Жилова Е.В. и соавт. Клинико - функциональные особенности артериальной гипертонии у больных хроническим обструктивным заболеванием легких. РМЖ. 2003; 9: 535-8.</mixed-citation><mixed-citation xml:lang="en">Задионченко В.С., Адашева Т.В., Жилова Е.В. и соавт. Клинико - функциональные особенности артериальной гипертонии у больных хроническим обструктивным заболеванием легких. РМЖ. 2003; 9: 535-8.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Дворецкий Л.И. Клинические рекомендации по ведению больных ХОБЛ в сочетании с артериальной гипертонией и другой патологией. РМЖ. 2005; 13: 672-5.</mixed-citation><mixed-citation xml:lang="en">Дворецкий Л.И. Клинические рекомендации по ведению больных ХОБЛ в сочетании с артериальной гипертонией и другой патологией. РМЖ. 2005; 13: 672-5.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Карпов Ю.А., Сорокин Е.В. Особенности лечения артериальной гипертонии при хронических обструктивных заболеваниях легких. РМЖ. 2003; 19: 1048-51.</mixed-citation><mixed-citation xml:lang="en">Карпов Ю.А., Сорокин Е.В. Особенности лечения артериальной гипертонии при хронических обструктивных заболеваниях легких. РМЖ. 2003; 19: 1048-51.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Andersson D, Rojdmark S. Improvement of glucose tolerance by verapamil in patients with non - insulin - dependent diabetes mellitus. Acta Med Scand 1981; 210 (1-2): 27-33.</mixed-citation><mixed-citation xml:lang="en">Andersson D, Rojdmark S. Improvement of glucose tolerance by verapamil in patients with non - insulin - dependent diabetes mellitus. Acta Med Scand 1981; 210 (1-2): 27-33.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Libretti A, Catalano M. Lipid profile during antihypertensive treatment. The SLIP Study Group: Study on Lipids with Isoptin Press. Drugs 1993; 46 (Suppl. 2): S.16-S.23.</mixed-citation><mixed-citation xml:lang="en">Libretti A, Catalano M. Lipid profile during antihypertensive treatment. The SLIP Study Group: Study on Lipids with Isoptin Press. Drugs 1993; 46 (Suppl. 2): S.16-S.23.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Rosei E, Dal Palu C, Leonetti G et al. Clinical results of the Verapamil in Hypertension and Atherosclerosis Study (VHAS). J Hypertension 1997; 15: 1337- 44.</mixed-citation><mixed-citation xml:lang="en">Rosei E, Dal Palu C, Leonetti G et al. Clinical results of the Verapamil in Hypertension and Atherosclerosis Study (VHAS). J Hypertension 1997; 15: 1337- 44.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Echizen H, Eichelbaum M. Clinical Pharmacokinetics of verapamil, nifedipine and diltiazem. Clin Pharmacokinetics 1986; 11: 425-49.</mixed-citation><mixed-citation xml:lang="en">Echizen H, Eichelbaum M. Clinical Pharmacokinetics of verapamil, nifedipine and diltiazem. Clin Pharmacokinetics 1986; 11: 425-49.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
