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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">systhiper</journal-id><journal-title-group><journal-title xml:lang="ru">Системные гипертензии</journal-title><trans-title-group xml:lang="en"><trans-title>Systemic Hypertension</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2075-082X</issn><issn pub-type="epub">2542-2189</issn><publisher><publisher-name>LLC «ИнтерМедсервис»</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">systhiper-483</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КАРДИОЛОГИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CARDIOLOGY</subject></subj-group></article-categories><title-group><article-title>Использование ивабрадина в рациональном лечении ишемической болезни сердца</article-title><trans-title-group xml:lang="en"><trans-title>The application of ivabradine in the management of ischaemic heart disease</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гуревич</surname><given-names>М. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Gurevich</surname><given-names>M. A.</given-names></name></name-alternatives><email xlink:type="simple">magurevich@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кузьменко</surname><given-names>Н. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Kuzmenko</surname><given-names>N. A.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ГБУЗ МО Московский областной научно-исследовательский клинический институт им. М.Ф.Владимирского</institution><country>Россия</country></aff><aff xml:lang="en"><institution>M.F.Vladimirskiy Moscow Regional Clinical Institute</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2016</year></pub-date><pub-date pub-type="epub"><day>23</day><month>12</month><year>2022</year></pub-date><volume>13</volume><issue>4</issue><fpage>26</fpage><lpage>29</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Гуревич М.А., Кузьменко Н.А., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Гуревич М.А., Кузьменко Н.А.</copyright-holder><copyright-holder xml:lang="en">Gurevich M.A., Kuzmenko N.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.syst-hypertension.ru/jour/article/view/483">https://www.syst-hypertension.ru/jour/article/view/483</self-uri><abstract><p>Ишемическая болезнь сердца на данный момент является не только тяжелым в клиническом плане заболеванием, требующим, как правило, мультидисциплинарного подхода, но и важной социальной и экономической проблемой. Контроль частоты сердечных сокращений - один из основных терапевтических принципов, который необходимо соблюдать у больных с ишемической болезнью сердца. В практической деятельности нередки случаи, когда существуют противопоказания к назначению β-адреноблокаторов для снижения частоты сердечных сокращений у таких больных (например, нарушения углеводного или липидного обменов). Альтернативой может служить препарат ивабрадин - If-ингибитор ионных потоков избирательного действия, характеризующийся отрицательным хронотропным действием и не оказывающий отрицательного инотропного действия, а также не влияющий на атриовентрикулярную проводимость и артериальное давление. Терапия ивабрадином, как правило, хорошо переносится, что увеличивает приверженность пациентов лечению. Одним из качественных генериков ивабрадина является препарат Раеном® («Гедеон Рихтер», Венгрия).</p></abstract><trans-abstract xml:lang="en"><p>Ischemic heart disease is not only serious disorder with special clinical characteristics and generally requiring multidisciplinary approach, but also a social and economic problem now. Heart rate control is one of the main therapeutic principles that should be applied in patients with ischemic heart disease. In practice there are always cases when β-blockers for reducing heart rate should not be used because of contraindications in patients (for example, disorders of carbohydrate and lipid metabolism). Ivabradine can be an alternative in this situation due to selective and specific inhibition of the If-channels current across the cardiac pacemaker, characterized by negative chronotropism without negative inotropic effect and without affecting atrioventricular conduction and blood pressure. Ivabradine therapy is generally well tolerated and increases adherence commitment of patients to treatment. Raenom® (Gedeon Richter, Hungary) is generic ivabradine of good-quality.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>ишемическая болезнь сердца</kwd><kwd>частота сердечных сокращений</kwd><kwd>осложнения</kwd><kwd>внезапная коронарная смерть</kwd><kwd>хроническая сердечная недостаточность</kwd><kwd>ивабрадин</kwd></kwd-group><kwd-group xml:lang="en"><kwd>ischemic heart disease</kwd><kwd>heart rate</kwd><kwd>complications</kwd><kwd>sudden cardiac death</kwd><kwd>chronic heart failure</kwd><kwd>ivabradine</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Российский статистический ежегодник-2014, Федеральная служба государственной статистики. электронный ресурс: www.gks.ru</mixed-citation><mixed-citation xml:lang="en">Российский статистический ежегодник-2014, Федеральная служба государственной статистики. электронный ресурс: www.gks.ru</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">ESC guidelines on the management of stable coronary artery disease, 2013. 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