systhiperСистемные гипертензииSystemic Hypertension2075-082X2542-2189LLC «ИнтерМедсервис»systhiper-500Research ArticleОБЗОРЫДигидропиридиновые антагонисты кальция: осознанный выборDihydropyridine calcium antagonists: conscious choiceОстроумоваО. Д.OstroumovaO. D.ostroumova.olga@mail.ruВикентьевВ. В.VikentevV. V.vvvikentiev@mail.ruАбросимовА. Г.AbrosimovA. G.noemail@neicon.ruСмолярчукЕ. А.SmoliarchukE. A.smolyarchuk@mail.ruФГБОУ ВО «Московский государственный медико-стоматологический университет им. А.И.Евдокимова» Минздрава России; ФГАОУ ВО «Первый Московский государственный университет им. И.М.Сеченова» Минздрава РоссииРоссияA.I.Evdokimov Moscow State University of Medicine and Dentistry of the Ministry of Health of the Russian Federation; I.M.Sechenov First Moscow State Medical University of the Ministry of Health of the Russian FederationRussian FederationФГБОУ ВО «Московский государственный медико-стоматологический университет им. А.И.Евдокимова» Минздрава РоссииРоссияA.I.Evdokimov Moscow State University of Medicine and Dentistry of the Ministry of Health of the Russian FederationRussian FederationФГАОУ ВО «Первый Московский государственный университет им. И.М.Сеченова» Минздрава РоссииРоссияI.M.Sechenov First Moscow State Medical University of the Ministry of Health of the Russian FederationRussian Federation2017231220221416168Copyright © Остроумова О.Д., Викентьев В.В., Абросимов А.Г., Смолярчук Е.А., 20222022Остроумова О.Д., Викентьев В.В., Абросимов А.Г., Смолярчук Е.А.Ostroumova O.D., Vikentev V.V., Abrosimov A.G., Smoliarchuk E.A.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.syst-hypertension.ru/jour/article/view/500

В статье приведены данные об особенностях фармакокинетики и фармакодинамики дигидропиридиновых антагонистов кальция. Рассмотрена доказательная база амлодипина в лечении артериальной гипертонии, ишемической болезни сердца, хронической сердечной недостаточности. Проведено сравнение эффективности, безопасности и особенностей применения в особых клинических ситуациях отдельных представителей класса дигидропиридиновых антагонистов кальция.

This article contains information concerning the aspects of pharmacokinetics and pharmacodynamics of dihydropyridine calcium antagonists. The authors have discussed the evidence-based amlodipine treatment of arterial hypertension, ischemic heart disease and chronic heart failure. The authors present the comparison of the efficacy, safety and application characteristics of the different dihydropyridine calcium antagonists that can be used in specific clinical cases.

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The authors declare that there are no conflicts of interest present.