systhiperСистемные гипертензииSystemic Hypertension2075-082X2542-2189LLC «ИнтерМедсервис»systhiper-526Research ArticleСТАТЬИARTICLESВзаимоотношение отдельных популяций лейкоцитов и деятельность сердечно-сосудистой системы у женщин, страдающих гипертонической болезньюRelationship between selected populations of leukocytes and cardiovascular system activity in women with essential hypertensionКузникБ. И.KuznikB. I.*bi_kuznik@mail.ruДавыдовС. О.DavydovS. O.noemail@neicon.ruГусеваЕ. С.GusevaE. S.noemail@neicon.ruСтепановА. В.StepanovA. V.avstep@rambler.ruСмоляковЮ. Н.SmolyakovY. N.noemail@neicon.ruЦыбиковН. Н.TsybikovN. N.noemail@neicon.ruФайнИ. В.FineI. V.noemail@neicon.ruМагенЭ.MagenE. ..allergologycom@gmail.comФГБОУ ВО ЧГМА; ИК «Академия здоровья»РоссияChita State Medical Academy; Innovative Clinic “Health Academy”Russian FederationФГБОУ ВО ЧГМАРоссияChita State Medical AcademyRussian FederationElfi-Tech Ltd., RehovotРоссияElfi-Tech LtdRussian FederationУниверситетский медицинский центр Барзилай, Университет им. Бен-ГурионаРоссияMedicine C Department, Barzilai Medical Center, Ben-Gurion University of the NegevRussian Federation2017231220221443237Copyright © Кузник Б.И., Давыдов С.О., Гусева Е.С., Степанов А.В., Смоляков Ю.Н., Цыбиков Н.Н., Файн И.В., Маген Э..., 20222022Кузник Б.И., Давыдов С.О., Гусева Е.С., Степанов А.В., Смоляков Ю.Н., Цыбиков Н.Н., Файн И.В., Маген Э.Kuznik B.I., Davydov S.O., Guseva E.S., Stepanov A.V., Smolyakov Y.N., Tsybikov N.N., Fine I.V., Magen E...Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.syst-hypertension.ru/jour/article/view/526

Цель - исследовать влияние количественных соотношений различных видов лейкоцитов на деятельность сердечно-сосудистой системы у здоровых людей и страдающих гипертонической болезнью (ГБ). Материалы и методы. Исследования проведены с участием 102 женщин, страдающих ГБ. Контрольную группу составили 30 здоровых пациенток. Результаты. У женщин, больных ГБ, как не занимающихся (ГБ-1), так и занимающихся регулярно кинезитерапией (ГБ-2), по сравнению с контролем повышено общее содержание лейкоцитов, а также соотношение НЕЙТР/ЭОЗ, ЛИМ/ЭОЗ, ЛИМ/БАЗ и ЭОЗ/БАЗ. У больных ГБ увеличены ударный объем и конечный диастолический объем левого желудочка, минутный объем сердца, повышены масса и индекс массы миокарда левого желудочка. У больных ГБ-1 баланс распределения скоростей в микроциркуляторном русле изменяется в сторону быстрых межслоевых процессов. У больных ГБ-2 эти изменения выражены в значительно меньшей степени. У здоровых женщин и больных ГБ обнаружены существенные взаимосвязи между лейкоцитарными соотношениями и уровнем систолического, диастолического, среднего, пульсового давления, показателями кардиогемодинамики и гемодинамическими индексами. Заключение. Регулярные занятия кинезитерапией приближают тесты, характеризующие состояние гемокардиодинамики, гемодинамические индексы, а также исследуемые корреляционные отношения к показателям, характерным для здоровых женщин. Представленные данные свидетельствуют о важной роли взаимоотношения различных популяций лейкоцитов в патогенезе ГБ.

Objective. To investigate the effect of the quantitative ratios of different types of white blood cells on the cardiovascular system in healthy individuals and patients with essential hypertension (EH). Materials and methods. The study was performed on 102 women suffering EH. The control group consisted of 30 healthy patients. Results. In women with EH, both non-engaged (EH-1) and regularly engaged in kinesitherapy (EH-2), compared with the control group, the total content of leukocytes was increased, as well as the ratios of NEUTR/EOS, LYM/EOS, LYM/BAS and EOS/BAS. In hypertensive patients increased stroke volume and end-diastolic left ventricular volume, cardiac output, increased mass and the index of left ventricular mass. In EH-1 patients group, the balance of velocity distribution in the microcirculatory bed changes to fast interlayer processes. In patients with EH-2, these changes are much less pronounced. In healthy women and patients with EH, significant relationships between leukocyte ratios and the level of systolic diastolic, mean, pulse pressure, cardiohemodynamics, hemodynamic indices were found. Conclusion. Regular practice of kinesitherapy brings the condition of cardiohemodynamics, hemodynamic indices, as well as the investigated correlations to the characteristic of healthy women. These data suggest an important role of the relationship of various leukocyte populations in the pathogenesis of EH.

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The authors declare that there are no conflicts of interest present.