<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">systhiper</journal-id><journal-title-group><journal-title xml:lang="ru">Системные гипертензии</journal-title><trans-title-group xml:lang="en"><trans-title>Systemic Hypertension</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2075-082X</issn><issn pub-type="epub">2542-2189</issn><publisher><publisher-name>LLC «ИнтерМедсервис»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.26442/2075-082X_2018.3.39-43</article-id><article-id custom-type="elpub" pub-id-type="custom">systhiper-557</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>СТАТЬИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ARTICLES</subject></subj-group></article-categories><title-group><article-title>Ожирение как предиктор сердечно-сосудистых заболеваний: роль локальных жировых депо</article-title><trans-title-group xml:lang="en"><trans-title>Obesity as a predictor for cardiovascular disease development: role of localized fat depot</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Азимова</surname><given-names>М. О.</given-names></name><name name-style="western" xml:lang="en"><surname>Azimova</surname><given-names>M. O.</given-names></name></name-alternatives><email xlink:type="simple">m.azimova@doconcall.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Блинова</surname><given-names>Н. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Blinova</surname><given-names>N. V.</given-names></name></name-alternatives><email xlink:type="simple">nat-cardio1@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Жернакова</surname><given-names>Ю. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Zhernakova</surname><given-names>Yu. V.</given-names></name></name-alternatives><email xlink:type="simple">juli001@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Чазова</surname><given-names>И. Е.</given-names></name><name name-style="western" xml:lang="en"><surname>Chazova</surname><given-names>I. E.</given-names></name></name-alternatives><email xlink:type="simple">c34h@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБУ «НМИЦ кардиологии»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>A.L.Myasnikov Institute of Clinical Cardiology National Medical Research Center of Cardiology of the Ministry of Health of the Russian Federation</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2018</year></pub-date><pub-date pub-type="epub"><day>23</day><month>12</month><year>2022</year></pub-date><volume>15</volume><issue>3</issue><fpage>39</fpage><lpage>43</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Азимова М.О., Блинова Н.В., Жернакова Ю.В., Чазова И.Е., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Азимова М.О., Блинова Н.В., Жернакова Ю.В., Чазова И.Е.</copyright-holder><copyright-holder xml:lang="en">Azimova M.O., Blinova N.V., Zhernakova Y.V., Chazova I.E.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.syst-hypertension.ru/jour/article/view/557">https://www.syst-hypertension.ru/jour/article/view/557</self-uri><abstract><p>В настоящее время отмечается неуклонный рост распространенности ожирения во всем мире. Известно, что именно висцеральное ожирение ассоциировано с высоким риском сердечно-сосудистых заболеваний и осложнений, однако доступные методы его верификации неточно отражают истинный объем висцеральной жировой ткани. В обзоре обсуждается значение локальных жировых депо как фактора риска сердечно-сосудистых заболеваний и раненного маркера поражения органов-мишеней у больных с ожирением. Рассматривается вариант использования толщины эпикардиального жира, оцениваемый методом эхокардиографии, как аналог окружности талии для более точной оценки наличия висцерального ожирения в рутинной практике.</p></abstract><trans-abstract xml:lang="en"><p>At present a steady increase of obesity prevalence is observed all over the world. It is known that specifically visceral obesity is associated with high risk of cardiovascular disease and their complications development, but the available verification methods do not determine the real visceral adipose tissue volume accurately. The importance of localized fat depot as a risk factor for cardiovascular diseases and as an early marker of target organs damage in obese patients is discussed in the review. An alternative method of epicardial adipose tissue thickness determined with the use of echocardiography used as waist circumference analogue for a more precise evaluation of visceral obesity in everyday practice is reviewed.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>ожирение</kwd><kwd>висцеральный эктопический жир</kwd><kwd>локальные жировые депо</kwd><kwd>эпикардиальная жировая ткань</kwd><kwd>паранефральная жировая ткань</kwd><kwd>сердечно-сосудистые заболевания</kwd></kwd-group><kwd-group xml:lang="en"><kwd>obesity</kwd><kwd>visceral ectopic fat</kwd><kwd>localized fat depot</kwd><kwd>epicardial adipose tissue</kwd><kwd>paranephral adipose tissue</kwd><kwd>cardiovascular disease</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Obesity and overweight. Report of a WHO Consultation on Obesity. WHO Technical report Series, 2016.</mixed-citation><mixed-citation xml:lang="en">Obesity and overweight. Report of a WHO Consultation on Obesity. WHO Technical report Series, 2016.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Ogden C.L, Carroll M.D, Lawman H.G et al. Trends in obesity prevalence among children and adolescents in the United States, 1988-1994 through 2013-2014. JAMA 2016; 315: 2292-9. DOI: 10.1001/jama.2016.6361</mixed-citation><mixed-citation xml:lang="en">Ogden C.L, Carroll M.D, Lawman H.G et al. Trends in obesity prevalence among children and adolescents in the United States, 1988-1994 through 2013-2014. JAMA 2016; 315: 2292-9. DOI: 10.1001/jama.2016.6361</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Ng M, Fleming T, Robinson M et al. Global, regional, and national prevalence of overweight and obesity in children and adults during 1980-2013, a systematic analysis for the global burden of Disease Study 2013. Lancet 2014; 384: 766-81. DOI: 10.1016/S0140-6736(14)60460-8</mixed-citation><mixed-citation xml:lang="en">Ng M, Fleming T, Robinson M et al. Global, regional, and national prevalence of overweight and obesity in children and adults during 1980-2013, a systematic analysis for the global burden of Disease Study 2013. Lancet 2014; 384: 766-81. DOI: 10.1016/S0140-6736(14)60460-8</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Global Health Observatory Data Repository. Report WHO [Internet]. Geneva: World Health Organization, 2013 [cited 2015 Feb 12].</mixed-citation><mixed-citation xml:lang="en">Global Health Observatory Data Repository. Report WHO [Internet]. Geneva: World Health Organization, 2013 [cited 2015 Feb 12].</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Ефремова Ю.Е., Ощепкова Е.В., Жернакова Ю.В. и др. Факторы риска сердечно-сосудистых заболеваний у лиц с высоким нормальным артериальным давлением в Российской Федерации (по данным эпидемиологического исследования ЭССЕ-РФ). Системные гипертензии. 2017; 14 (1): 6-11.</mixed-citation><mixed-citation xml:lang="en">Ефремова Ю.Е., Ощепкова Е.В., Жернакова Ю.В. и др. Факторы риска сердечно-сосудистых заболеваний у лиц с высоким нормальным артериальным давлением в Российской Федерации (по данным эпидемиологического исследования ЭССЕ-РФ). Системные гипертензии. 2017; 14 (1): 6-11.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Preventing and Managing the Global Epidemic of Obesity. Report of a WHO Consultation on Obesity. Geneva: WHO Technical report Series, 1997.</mixed-citation><mixed-citation xml:lang="en">Preventing and Managing the Global Epidemic of Obesity. Report of a WHO Consultation on Obesity. Geneva: WHO Technical report Series, 1997.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Flegal K.M, Kit B.K, Orpana H et al. Association of all-cause mortality with overweight and obesity using standard body mass index categories: a systematic review and meta-analysis. JAMA 2013; 309 (1): 71-82.</mixed-citation><mixed-citation xml:lang="en">Flegal K.M, Kit B.K, Orpana H et al. Association of all-cause mortality with overweight and obesity using standard body mass index categories: a systematic review and meta-analysis. JAMA 2013; 309 (1): 71-82.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Gami A.S, Witt B.J, Howard D.E et al. Metabolic syndrome and risk of incident cardiovascular events and death: a systematic review and meta-analysis of longitudinal studies. J Am Coll Cardiol 2007; 49: 403-14.</mixed-citation><mixed-citation xml:lang="en">Gami A.S, Witt B.J, Howard D.E et al. Metabolic syndrome and risk of incident cardiovascular events and death: a systematic review and meta-analysis of longitudinal studies. J Am Coll Cardiol 2007; 49: 403-14.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Hubert H.B, Feinleib M, McNamara P.M et al. Obesity as an independent risk factor for cardiovascular disease: a 26-year follow-up of participants in the Framingham heart study. Circulation 1983; 67: 968-77.</mixed-citation><mixed-citation xml:lang="en">Hubert H.B, Feinleib M, McNamara P.M et al. Obesity as an independent risk factor for cardiovascular disease: a 26-year follow-up of participants in the Framingham heart study. Circulation 1983; 67: 968-77.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Da naei G, Lu Y, Singh G.M et al. Cardiovascular disease, chronic kidney disease, and diabetes mortality burden of cardiometabolic risk factors from 1980 to 2010: a comparative risk assessment. Lancet Diabetes Endocrinol 2014; 2 (8): 634-47. DOI: 10.1016/S2213-8587 (14)70102-0</mixed-citation><mixed-citation xml:lang="en">Da naei G, Lu Y, Singh G.M et al. Cardiovascular disease, chronic kidney disease, and diabetes mortality burden of cardiometabolic risk factors from 1980 to 2010: a comparative risk assessment. Lancet Diabetes Endocrinol 2014; 2 (8): 634-47. DOI: 10.1016/S2213-8587 (14)70102-0</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Wassertheil-Smoller S, Fann C, Allman R.M et al. Relation of low body mass to death and stroke in the systolic hypertension in the elderly program. The SHEP Cooperative Research Group. Arch Intern Med 2000; 160 (4): 494-500.</mixed-citation><mixed-citation xml:lang="en">Wassertheil-Smoller S, Fann C, Allman R.M et al. Relation of low body mass to death and stroke in the systolic hypertension in the elderly program. The SHEP Cooperative Research Group. Arch Intern Med 2000; 160 (4): 494-500.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Romero-Corral A, Montori V.M, Somers V.K et al. Association of bodyweight with total mortality and with cardiovascular events in coronary artery disease: a systematic review of cohort studies. Lancet 2006; 368 (9536): 666-78.</mixed-citation><mixed-citation xml:lang="en">Romero-Corral A, Montori V.M, Somers V.K et al. Association of bodyweight with total mortality and with cardiovascular events in coronary artery disease: a systematic review of cohort studies. Lancet 2006; 368 (9536): 666-78.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Rakel D. Integrative Medicine - E-Book. Elsevier Health Sciences, 2017.</mixed-citation><mixed-citation xml:lang="en">Rakel D. Integrative Medicine - E-Book. Elsevier Health Sciences, 2017.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Жернакова Ю.В., Чазова И.Е., Ощепкова Е.В. и др. Распространенность сахарного диабета в популяции больных артериальной гипертонией. По данным исследования ЭССЕ-РФ. Системные гипертензии. 2018. 15 (1): 56-62. DOI: 10.26442/2075-082X_15.1.56-62</mixed-citation><mixed-citation xml:lang="en">Жернакова Ю.В., Чазова И.Е., Ощепкова Е.В. и др. Распространенность сахарного диабета в популяции больных артериальной гипертонией. По данным исследования ЭССЕ-РФ. Системные гипертензии. 2018. 15 (1): 56-62. DOI: 10.26442/2075-082X_15.1.56-62</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Cornier M.A, Després J.P, Davis N et al. Assessing Adiposity: A Scientific Statement From the American Heart Association. Circulation 2011; 124 (18): 1996-2019. DOI: 10.1161/CIR.0b013e318233bc6a</mixed-citation><mixed-citation xml:lang="en">Cornier M.A, Després J.P, Davis N et al. Assessing Adiposity: A Scientific Statement From the American Heart Association. Circulation 2011; 124 (18): 1996-2019. DOI: 10.1161/CIR.0b013e318233bc6a</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Буторова Е.А., Елфимова Е.М., Шария М.А. и др. Возможности магнитно-резонансной томографии в оценке мягких тканей вокруг верхних дыхательных путей у больных с ожирением и синдромом обструктивного апноэ во время сна. Вестн. рентгенологии и радиологии. 2017; 98 (2): 79-85. https: //doi.org/10.20862/0042-4676-2017-98-2-79-85</mixed-citation><mixed-citation xml:lang="en">Буторова Е.А., Елфимова Е.М., Шария М.А. и др. Возможности магнитно-резонансной томографии в оценке мягких тканей вокруг верхних дыхательных путей у больных с ожирением и синдромом обструктивного апноэ во время сна. Вестн. рентгенологии и радиологии. 2017; 98 (2): 79-85. https: //doi.org/10.20862/0042-4676-2017-98-2-79-85</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Santanasto A.J, Goodpaster B.H, Kritchevsky S.B. Body Composition Remodeling and Mortality: The Health Aging and Body Composition Study Journals of Gerontology: Medical Sciences cite as. J Gerontol A Biol Sci Med Sci 2017; 72 (4): 513-9. DOI: 10.1093/gerona/glw163</mixed-citation><mixed-citation xml:lang="en">Santanasto A.J, Goodpaster B.H, Kritchevsky S.B. Body Composition Remodeling and Mortality: The Health Aging and Body Composition Study Journals of Gerontology: Medical Sciences cite as. J Gerontol A Biol Sci Med Sci 2017; 72 (4): 513-9. DOI: 10.1093/gerona/glw163</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Чазова И.Е., Жернакова Ю.В., Ощепкова Е.В. и др. Распространенность факторов риска сердечно- сосудистых заболеваний в российской популяции больных артериальной гипертонией. Кардиология. 2014; 54 (10): 4-10. DOI: https: //dx.doi.org/10.18565/cardio.2014.10.4-12</mixed-citation><mixed-citation xml:lang="en">Чазова И.Е., Жернакова Ю.В., Ощепкова Е.В. и др. Распространенность факторов риска сердечно- сосудистых заболеваний в российской популяции больных артериальной гипертонией. Кардиология. 2014; 54 (10): 4-10. DOI: https: //dx.doi.org/10.18565/cardio.2014.10.4-12</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Yui H, Otagiri K, Nakamura C еt al. Impact of gender difference on abdominal fat accumulation and coronary artery disease severity stratified by computed tomography-derived SYNTAX score. Eur Heart J 2017.</mixed-citation><mixed-citation xml:lang="en">Yui H, Otagiri K, Nakamura C еt al. Impact of gender difference on abdominal fat accumulation and coronary artery disease severity stratified by computed tomography-derived SYNTAX score. Eur Heart J 2017.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Стародубова А.В., Кисляк О.А. Ожирение как фактор риска сердечно-сосудистых заболеваний. Обзор литературы. Фарматека. 2015; 17 (310): 28-35.</mixed-citation><mixed-citation xml:lang="en">Стародубова А.В., Кисляк О.А. Ожирение как фактор риска сердечно-сосудистых заболеваний. Обзор литературы. Фарматека. 2015; 17 (310): 28-35.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Xia N, Li H. The role of perivascular adipose tissue in obesity-induced vascular dysfunction. Br J Pharmacol 2017; 174 (20): 3425-42. DOI: 10.1111/bph.13650</mixed-citation><mixed-citation xml:lang="en">Xia N, Li H. The role of perivascular adipose tissue in obesity-induced vascular dysfunction. Br J Pharmacol 2017; 174 (20): 3425-42. DOI: 10.1111/bph.13650</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Fernández-Alfonso M.S, Gil-Ortega M, García-Prieto C.F et al. Mechanisms of Perivascular Adipose Tissue Dysfunction in Obesity. Int J Endocrinol 2013; 2013: 1-8. DOI: 10.1155/2013/402053</mixed-citation><mixed-citation xml:lang="en">Fernández-Alfonso M.S, Gil-Ortega M, García-Prieto C.F et al. Mechanisms of Perivascular Adipose Tissue Dysfunction in Obesity. Int J Endocrinol 2013; 2013: 1-8. DOI: 10.1155/2013/402053</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Narayan K.M, Boyle J.P, Geiss L.S et al. Impact of recent increase in incidence on future diabetes burden: U.S. 2005-2050. Diabetes Care 2006; 29 (9): 2114-6.</mixed-citation><mixed-citation xml:lang="en">Narayan K.M, Boyle J.P, Geiss L.S et al. Impact of recent increase in incidence on future diabetes burden: U.S. 2005-2050. Diabetes Care 2006; 29 (9): 2114-6.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Kopelman P.G. Obesity as a medical problem. Nature 2000; 404 (6778): 635-43.</mixed-citation><mixed-citation xml:lang="en">Kopelman P.G. Obesity as a medical problem. Nature 2000; 404 (6778): 635-43.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Montani J.P, Carroll J.F, Dwyer T.M et al. Ectopic fat storage in heart, blood vessels and kidneys in the pathogenesis of cardiovascular diseases. Int J Obes Relat Metab Dis 2004; 28 (Suppl. 4): S58-65. DOI: 10.1038/sj.ijo.0802858</mixed-citation><mixed-citation xml:lang="en">Montani J.P, Carroll J.F, Dwyer T.M et al. Ectopic fat storage in heart, blood vessels and kidneys in the pathogenesis of cardiovascular diseases. Int J Obes Relat Metab Dis 2004; 28 (Suppl. 4): S58-65. DOI: 10.1038/sj.ijo.0802858</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Axelsson J, Moller H.J, Witasp A et al. Changes in fat mass correlate with changes in soluble sCD163, a marker of mature macrophages, in patients with CKD. Am J Kidney Dis 2006; 48: 916-25.</mixed-citation><mixed-citation xml:lang="en">Axelsson J, Moller H.J, Witasp A et al. Changes in fat mass correlate with changes in soluble sCD163, a marker of mature macrophages, in patients with CKD. Am J Kidney Dis 2006; 48: 916-25.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Kurella M, Luan J, Lash J.P et al. Self-assessed sleep quality in chronic kidney disease. Int Urol Nephrol 2005; 37 (1): 159-65. DOI: 10.1007/s11255-004-4654-z</mixed-citation><mixed-citation xml:lang="en">Kurella M, Luan J, Lash J.P et al. Self-assessed sleep quality in chronic kidney disease. Int Urol Nephrol 2005; 37 (1): 159-65. DOI: 10.1007/s11255-004-4654-z</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Knight S.F, Imig J.D. Obesity, insulin resistance, and renal function. Microcirculation 2007; 14: 349-62.</mixed-citation><mixed-citation xml:lang="en">Knight S.F, Imig J.D. Obesity, insulin resistance, and renal function. Microcirculation 2007; 14: 349-62.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Iacobellis G. Epicardial and pericardial fat: close, but very different. Obesity 2009; 17: 625.</mixed-citation><mixed-citation xml:lang="en">Iacobellis G. Epicardial and pericardial fat: close, but very different. Obesity 2009; 17: 625.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Owan T.E, Redfield M.M. Epidemiology of diastolic heart failure. Prog Cardiovasc Dis 2005; 47: 320-32.</mixed-citation><mixed-citation xml:lang="en">Owan T.E, Redfield M.M. Epidemiology of diastolic heart failure. Prog Cardiovasc Dis 2005; 47: 320-32.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Kossaify A, Nicolas N. Impact of overweight and obesity on left ventricular diastolic function and value of tissue Doppler echocardiography. Clin Med Insights Cardiol 2013; 7: 43-50.</mixed-citation><mixed-citation xml:lang="en">Kossaify A, Nicolas N. Impact of overweight and obesity on left ventricular diastolic function and value of tissue Doppler echocardiography. Clin Med Insights Cardiol 2013; 7: 43-50.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Hatem S.N, Sanders P. Epicardial adipose tissue and atrial fibrillation. Cardiovasc Res 2014; 102: 205-13.</mixed-citation><mixed-citation xml:lang="en">Hatem S.N, Sanders P. Epicardial adipose tissue and atrial fibrillation. Cardiovasc Res 2014; 102: 205-13.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Mahmood S.S, Levy D, Vasan R.S et al. The Framingham Heart Study and the epidemiology of cardiovascular disease: a historical perspective. Lancet 2014; 383 (9921): 999-1008. DOI: 10.1016/S0140-6736 (13)61752-3</mixed-citation><mixed-citation xml:lang="en">Mahmood S.S, Levy D, Vasan R.S et al. The Framingham Heart Study and the epidemiology of cardiovascular disease: a historical perspective. Lancet 2014; 383 (9921): 999-1008. DOI: 10.1016/S0140-6736 (13)61752-3</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Mazurek T, Zhang L.F, Zalewski A. et al. Human epicardial adipose tissue is a source of inflammatory markers. Circulation 2003; 108: 2460-6.</mixed-citation><mixed-citation xml:lang="en">Mazurek T, Zhang L.F, Zalewski A. et al. Human epicardial adipose tissue is a source of inflammatory markers. Circulation 2003; 108: 2460-6.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Baker A.R, Silva N.F, Quinn D.W et al. Human epicardial adipose tissue expresses a pathogenic profile of adipocytokines in patients with cardiovascular disease. Cardiovasc Diabet 2006; 5: 1.</mixed-citation><mixed-citation xml:lang="en">Baker A.R, Silva N.F, Quinn D.W et al. Human epicardial adipose tissue expresses a pathogenic profile of adipocytokines in patients with cardiovascular disease. Cardiovasc Diabet 2006; 5: 1.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Hirata Y, Tabata M, Kurobe H et al. Coronary atherosclerosis is associated with macrophage polarization in epicardial adipose tissue. J Am Coll Cardiol 2011; 58: 248-55.</mixed-citation><mixed-citation xml:lang="en">Hirata Y, Tabata M, Kurobe H et al. Coronary atherosclerosis is associated with macrophage polarization in epicardial adipose tissue. J Am Coll Cardiol 2011; 58: 248-55.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Park H, Choi S et al. Association of epicardial fat with left ventricular diastolic function in subjects with metabolic syndrome: assessment using 2 dimensional echocardiography. BMC Cardiovasc Dis 2014; 14: 3.</mixed-citation><mixed-citation xml:lang="en">Park H, Choi S et al. Association of epicardial fat with left ventricular diastolic function in subjects with metabolic syndrome: assessment using 2 dimensional echocardiography. BMC Cardiovasc Dis 2014; 14: 3.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Дружилов М.А., Бетелева Ю. Е., Кузнецова Т.Ю. Толщина эпикардиального жира - альтернатива окружности талии как самостоятельный или второй основной критерий метаболического синдрома? Рос. кардиол. журн. 2014; 3 (107): 76-81.</mixed-citation><mixed-citation xml:lang="en">Дружилов М.А., Бетелева Ю. Е., Кузнецова Т.Ю. Толщина эпикардиального жира - альтернатива окружности талии как самостоятельный или второй основной критерий метаболического синдрома? Рос. кардиол. журн. 2014; 3 (107): 76-81.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Iacobellis G, Ribaudo M, Assael F et al. Echocardiographic epicardial adipose tissue is related to anthropometric and clinical parameters of metabolic syndrome: a new indicator of cardiovascular risk. J Clin Endocrinol Metab 2003, 88 (11): 5163-8.</mixed-citation><mixed-citation xml:lang="en">Iacobellis G, Ribaudo M, Assael F et al. Echocardiographic epicardial adipose tissue is related to anthropometric and clinical parameters of metabolic syndrome: a new indicator of cardiovascular risk. J Clin Endocrinol Metab 2003, 88 (11): 5163-8.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
