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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">systhiper</journal-id><journal-title-group><journal-title xml:lang="ru">Системные гипертензии</journal-title><trans-title-group xml:lang="en"><trans-title>Systemic Hypertension</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2075-082X</issn><issn pub-type="epub">2542-2189</issn><publisher><publisher-name>LLC «ИнтерМедсервис»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.26442/2075082X.2018.4.180116</article-id><article-id custom-type="elpub" pub-id-type="custom">systhiper-559</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>СТАТЬИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ARTICLES</subject></subj-group></article-categories><title-group><article-title>Концепция «полипилл» в современной кардиологии</article-title><trans-title-group xml:lang="en"><trans-title>Polypill" conception in modern cardiology</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Чазова</surname><given-names>И. Е.</given-names></name><name name-style="western" xml:lang="en"><surname>Chazova</surname><given-names>I. E.</given-names></name></name-alternatives><email xlink:type="simple">c34h@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Аксенова</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Aksenova</surname><given-names>A. V.</given-names></name></name-alternatives><email xlink:type="simple">aksenovaannav@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Жернакова</surname><given-names>Ю. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Zhernakova</surname><given-names>Yu. V.</given-names></name></name-alternatives><email xlink:type="simple">juli001@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБУ «Национальный медицинский исследовательский центр кардиологии» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>National Medical Research Center for Cardiology of the Ministry of Health of the Russian Federation</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2018</year></pub-date><pub-date pub-type="epub"><day>23</day><month>12</month><year>2022</year></pub-date><volume>15</volume><issue>4</issue><fpage>6</fpage><lpage>7</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Чазова И.Е., Аксенова А.В., Жернакова Ю.В., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Чазова И.Е., Аксенова А.В., Жернакова Ю.В.</copyright-holder><copyright-holder xml:lang="en">Chazova I.E., Aksenova A.V., Zhernakova Y.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.syst-hypertension.ru/jour/article/view/559">https://www.syst-hypertension.ru/jour/article/view/559</self-uri><abstract><p>Объединение препаратов с антигипертензивным, гиполипидемическим, гипогликемическим и антиагрегантным действием в одну таблетку существенно повышает приверженность лечению и обеспечивает множественный контроль факторов риска, снижая риск развития сердечно-сосудистых заболеваний и фатальных событий. При этом в настоящее время еще не получены убедительные доказательства, что использование полипилла в кардиологии приводит к большему снижению частоты развития первичных конечных точек (общая смертность, фатальный инфаркт миокарда, острое нарушение мозгового кровообращения и т.д.), чем стандартная стратегия лечения. К</p></abstract><trans-abstract xml:lang="en"><p>Combining treatments with antihypertensive, lipid lowering, antidiabetic and antiplatelet effects into a single pill significantly increases adherence to treatment, provides multiple control of risk factors and reduces the risk of cardiovascular diseases and fatal events. At the same time, there is still no convincing evidence that the using polypill in cardiology instead of the standard treatment strategy leads to a greater reduction in the incidence of primary end points (total mortality, fatal myocardial infarction, stroke, etc.)</p></trans-abstract><kwd-group xml:lang="ru"><kwd>полипилл</kwd><kwd>антигипертензивная терапия</kwd><kwd>сердечно-сосудистый риск</kwd></kwd-group><kwd-group xml:lang="en"><kwd>polypill</kwd><kwd>antihypertensive treatment</kwd><kwd>cardiovascular risk</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Simpson S.H, Eurich D.T, Majumdar S.R et al. A meta-analysis of the ssociation between adherence to drug therapy and mortality. BMJ 2006; 333: 315.</mixed-citation><mixed-citation xml:lang="en">Simpson S.H, Eurich D.T, Majumdar S.R et al. 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