systhiperСистемные гипертензииSystemic Hypertension2075-082X2542-2189LLC «ИнтерМедсервис»10.26442/2075082X.2020.4.200556systhiper-619Research ArticleСТАТЬИARTICLESЭффективность и безопасность применения фиксированной комбинации азилсартана медоксомила с хлорталидоном у больных сахарным диабетомEfficacy and safety of using a fixed-dose combination of azilsartan medoxomil and chlorthalidone in patients with diabetes mellitushttps://orcid.org/0000-0001-7895-9068ЖернаковаЮ. В.ZhernakovaJ. V.juli001@mail.ruhttps://orcid.org/0000-0002-9822-4357ЧазоваИ. Е.ChazovaI. E.c34h@yandex.ruИнститут клинической кардиологии им. А.Л. Мясникова ФГБУ «Национальный медицинский исследовательский центр кардиологии» Минздрава России; ФГАОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава РоссииРоссияMyasnikov Institute of Clinical Cardiology, National Medical Research Center of Cardiology; Pirogov Russian National Research Medical UniversityRussian FederationИнститут клинической кардиологии им. А.Л. Мясникова ФГБУ «Национальный медицинский исследовательский центр кардиологии» Минздрава РоссииРоссияMyasnikov Institute of Clinical Cardiology, National Medical Research Center of CardiologyRussian Federation2020231220221746873Copyright © Жернакова Ю.В., Чазова И.Е., 20222022Жернакова Ю.В., Чазова И.Е.Zhernakova J.V., Chazova I.E.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.syst-hypertension.ru/jour/article/view/619

Все последние международные и национальные рекомендации, регламентирующие лечение больных артериальной гипертонией, предлагают унифицированный подход к назначению антигипертензивной терапии. Абсолютному большинству пациентов, к которым относятся и больные сахарным диабетом, показаны комбинированные лекарственные средства. В качестве препаратов первого ряда рекомендуются средства, воздействующие на ренин-ангиотензиновую систему, блокаторы кальциевых каналов или диуретики. Требования, предъявляемые к диуретикам для применения у этой категории пациентов, особенно жесткие. При необходимости использования у больных сахарным диабетом в составе антигипертензивной терапии мочегонного предпочтение должно отдаваться тиазидоподобным диуретикам. Всем этим требованиям соответствует комбинированный препарат Эдарби® Кло, представляющий собой фиксированную комбинацию блокатора рецепторов ангиотензина азилсартана медоксомила и тиазидоподобного диуретика хлорталидона. Наряду с выраженным антигипертензивным эффектом Эдарби® Кло оказывает положительное влияние на метаболические показатели, параметры воспаления и предотвращает поражение органов-мишеней, что позволяет рекомендовать его как средство выбора у данной категории больных.

All resent international and national guidelines for the treatment of patients with arterial hypertension offer a unified approach to the prescription of antihypertensive therapy. The vast majority of patients, including those with diabetes mellitus, require combined drugs. Renin-angiotensin-aldosterone system blockers, calcium channel blockers or diuretics are recommended as first-line therapy. The requirements for diuretics which can be used in this category of patients are especially strong. If patients with diabetes mellitus need diuretics as part of their antihypertensive therapy, thiazide-like diuretics should be preferred. Edarbi® Clo, which is a fixed-dose combination of angiotensin receptor blocker azilsartan medoxomil and thiazide-like diuretic chlorthalidone met all these requirements. Along with its strong antihypertensive effect, Edarbi® Clo has a beneficial effect on metabolism parameters, inflammation parameters and prevents damage to target organs, which makes it possible to recommend it as a drug of choice in this category of patients.

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The authors declare that there are no conflicts of interest present.