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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">systhiper</journal-id><journal-title-group><journal-title xml:lang="ru">Системные гипертензии</journal-title><trans-title-group xml:lang="en"><trans-title>Systemic Hypertension</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2075-082X</issn><issn pub-type="epub">2542-2189</issn><publisher><publisher-name>LLC «ИнтерМедсервис»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.26442/2075082X.2021.1.200724</article-id><article-id custom-type="elpub" pub-id-type="custom">systhiper-657</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОР</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEW</subject></subj-group></article-categories><title-group><article-title>Неконтролируемая артериальная гипертония: основные причины, особенности патогенеза и подходы к лечению</article-title><trans-title-group xml:lang="en"><trans-title>Uncontrolled arterial hypertension: main causes, features of pathogenesis and approaches to treatment</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2686-3026</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Денисова</surname><given-names>А. Р.</given-names></name><name name-style="western" xml:lang="en"><surname>Denisova</surname><given-names>A. R.</given-names></name></name-alternatives><email xlink:type="simple">nastya4358@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7381-7818</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Солнцева</surname><given-names>Т. Д.</given-names></name><name name-style="western" xml:lang="en"><surname>Solntseva</surname><given-names>T. D.</given-names></name></name-alternatives><email xlink:type="simple">Tatanasolnceva372@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0060-095X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сивакова</surname><given-names>О. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Sivakova</surname><given-names>O. A.</given-names></name></name-alternatives><email xlink:type="simple">ya.olga-siv2012@ya.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9822-4357</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Чазова</surname><given-names>И. Е.</given-names></name><name name-style="western" xml:lang="en"><surname>Chazova</surname><given-names>I. E.</given-names></name></name-alternatives><email xlink:type="simple">c34h@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Институт клинической кардиологии им. А.Л. Мясникова ФГБУ «Национальный медицинский исследовательский центр кардиологии» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Myasnikov Institute of Clinical Cardiology, National Medical Research Center of Cardiology</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2021</year></pub-date><pub-date pub-type="epub"><day>06</day><month>02</month><year>2023</year></pub-date><volume>18</volume><issue>1</issue><fpage>13</fpage><lpage>18</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Денисова А.Р., Солнцева Т.Д., Сивакова О.А., Чазова И.Е., 2023</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="ru">Денисова А.Р., Солнцева Т.Д., Сивакова О.А., Чазова И.Е.</copyright-holder><copyright-holder xml:lang="en">Denisova A.R., Solntseva T.D., Sivakova O.A., Chazova I.E.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.syst-hypertension.ru/jour/article/view/657">https://www.syst-hypertension.ru/jour/article/view/657</self-uri><abstract><p>Пациенты с наличием артериальной гипертонии (АГ) представляют особую группу населения с высоким риском развития сердечно-сосудистых заболеваний. Наиболее сложно поддающимися контролю являются резистентная и рефрактерная АГ. В настоящее время известно, что пациенты с недостижением целевых значений артериального давления имеют худший прогноз с точки зрения как сердечно-сосудистых событий, так и общей смертности. В данном обзоре представлены актуальные вопросы, касающиеся особенностей патогенеза, методов лечения, а также прогноза у больных резистентной и рефрактерной АГ.</p></abstract><trans-abstract xml:lang="en"><p>Patients with arterial hypertension represent a special population group with a high risk of developing cardiovascular diseases. The most difficult to control are resistant and refractory hypertension. It is known that patients with uncontrolled hypertension have a worse prognosis, both in terms of cardiovascular events and all-cause mortality. This review presents topical issues related to the features of pathogenesis, treatment and prognosis in patients with refractory and refractory hypertension.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>сердечно-сосудистые заболевания</kwd><kwd>рефрактерная артериальная гипертония</kwd><kwd>резистентная артериальная гипертония</kwd></kwd-group><kwd-group xml:lang="en"><kwd>cardiovascular diseases</kwd><kwd>refractory arterial hypertension</kwd><kwd>resistant arterial hypertension</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Stanaway JD, et al. Global, regional, and national comparative risk assessment of 84 behavioural, environmenta and occupational, and metabolic risks or clusters of risks for 195 countries and territories, 1990-2017: a systematic analysis for the global burden of disease study 2017. 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