systhiperСистемные гипертензииSystemic Hypertension2075-082X2542-2189LLC «ИнтерМедсервис»10.26442/2075082X.2021.4.201305systhiper-668Research ArticleКЛИНИЧЕСКИЙ СЛУЧАЙCASE REPORTВозможности нового представителя агониста рецепторов глюкагоноподобного пептида-1 семаглутида в улучшении диастолической функции левого желудочка у пациентки с артериальной гипертонией и сахарным диабетом 2-го типаPossibilities of a new glucagon-like peptide-1 receptor agonist Semaglutide in improving left ventricular diastolic function in a patient with arterial hypertension and type 2 diabetes mellituАзимоваМ. Р.AzimovaM. R.azimovamak@gmail.comhttps://orcid.org/0000-0001-7895-9068ЖернаковаЮ. В.ZhernakovaJ. V.juli001@mail.ruИнститут клинической кардиологии им. А.Л. Мясникова ФГБУ «Национальный медицинский исследовательский центр кардиологии» Минздрава РоссииРоссияMyasnikov Institute of Clinical Cardiology, National Medical Research Center of CardiologyRussian Federation202106022023184186192Copyright © Азимова М.Р., Жернакова Ю.В., 20232023Азимова М.Р., Жернакова Ю.В.Azimova M.R., Zhernakova J.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.syst-hypertension.ru/jour/article/view/668

Появление новых классов сахароснижающих препаратов, позволяющих добиться дополнительного снижения сердечно-сосудистого риска (ССР), кардинально изменило подходы к ведению пациентов с сахарным диабетом 2-го типа. Наиболее значимые изменения коснулись стратегии выбора сахароснижающей терапии со сменой приоритетов с уровня гликемии на уровень ССР, которому отдана ведущая роль при выборе класса антидиабетических препаратов. Вместе с тем механизмы, посредством которых снижается ССР, во многом остаются неизученными. Изучение возможностей влияния нового представителя агониста рецепторов глюкагоноподобного пептида-1 семаглутида на доклиническую стадию диастолической дисфункции представляет несомненный интерес. Статья посвящена описанию клинического случая использования семаглутида у пациентки с артериальной гипертонией и сахарным диабетом 2-го типа.

The emergence of new classes of glucose-lowering drugs that can further reduce cardiovascular risk (CVR) have fundamentally changed the approach to the management of patients with type 2 diabetes mellitus. The most significant changes concerned the strategy of choosing glucose-lowering therapy with a change in priorities from the glycemia level to CVR, which plays a key role in choosing a class of antidiabetic drugs. At the same time, the mechanisms responsible for lowering CVR remain largely unclear. Of undoubted interest is the study of effects of a new glucagon-like peptide-1 receptor agonist, Semaglutide, on the preclinical stage of diastolic dysfunction. The article presents a clinical case of the use of Semaglutide in a patient with arterial hypertension and type 2 diabetes mellitus.

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The authors declare that there are no conflicts of interest present.