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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">systhiper</journal-id><journal-title-group><journal-title xml:lang="ru">Системные гипертензии</journal-title><trans-title-group xml:lang="en"><trans-title>Systemic Hypertension</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2075-082X</issn><issn pub-type="epub">2542-2189</issn><publisher><publisher-name>LLC «ИнтерМедсервис»</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">systhiper-698</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>СТАТЬИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ARTICLES</subject></subj-group></article-categories><title-group><article-title>Современные аспекты
фармакотерапии артериальной
гипертензии. Возможности урапидила</article-title><trans-title-group xml:lang="en"><trans-title></trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Морозова</surname><given-names>Т. Е.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff xml:lang="ru" id="aff-1"><institution>ГОУ ВПО Первый московский государственный медицинский университет им. И.М.Сеченова Минздравсоцразвития РФ</institution><country>Russian Federation</country></aff><pub-date pub-type="collection"><year>2011</year></pub-date><pub-date pub-type="epub"><day>09</day><month>02</month><year>2023</year></pub-date><volume>8</volume><issue>3</issue><fpage>16</fpage><lpage>20</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Морозова Т.Е., 2023</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="ru">Морозова Т.Е.</copyright-holder><copyright-holder xml:lang="en">Морозова Т.Е.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.syst-hypertension.ru/jour/article/view/698">https://www.syst-hypertension.ru/jour/article/view/698</self-uri></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Шальнова С.А., Баланова Ю.А., Константинов В. В. и др. Артериальная гипертония: распространенность, осведомленность, прием антигипертензивных препаратов и эффективность лечения среди населения Российской Федерации. РКЖ. 2006; 4: 45-50.</mixed-citation><mixed-citation xml:lang="en">Шальнова С.А., Баланова Ю.А., Константинов В. В. и др. Артериальная гипертония: распространенность, осведомленность, прием антигипертензивных препаратов и эффективность лечения среди населения Российской Федерации. РКЖ. 2006; 4: 45-50.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Ezzati M, Lopez A, Rodgers A, Vander Hoorn S et al. Comparative Quantification of Health Risks: Global and Regional Burden of Disease Attributable to Selected Major Risk Factors. Ge-neva: World Health Organization 2004.</mixed-citation><mixed-citation xml:lang="en">Ezzati M, Lopez A, Rodgers A, Vander Hoorn S et al. Comparative Quantification of Health Risks: Global and Regional Burden of Disease Attributable to Selected Major Risk Factors. Ge-neva: World Health Organization 2004.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Chobanian AV. Shattuck Lecture. The hypertension paradox - more uncontrolled disease de-spite improved therapy. N Engl J Med 2009; 361: 878-87.</mixed-citation><mixed-citation xml:lang="en">Chobanian AV. Shattuck Lecture. The hypertension paradox - more uncontrolled disease de-spite improved therapy. N Engl J Med 2009; 361: 878-87.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Диагностика и лечение артериальной гипертонии. Рекомендаци РМОАГ/ВНОК, четвертый пересмотр. 2010.</mixed-citation><mixed-citation xml:lang="en">Диагностика и лечение артериальной гипертонии. Рекомендаци РМОАГ/ВНОК, четвертый пересмотр. 2010.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Hunt KJ, Resendez RG, Williams K et al. San Antonio Heart StudyNational Cho-lesterol Edu-cation Program versus World Health Organization metabolic syndrome in relation to all-cause and cardiovascular mortality in the San Antonio Heart Study. Circulation 2004; 110 (10): 1251-7.</mixed-citation><mixed-citation xml:lang="en">Hunt KJ, Resendez RG, Williams K et al. San Antonio Heart StudyNational Cho-lesterol Edu-cation Program versus World Health Organization metabolic syndrome in relation to all-cause and cardiovascular mortality in the San Antonio Heart Study. Circulation 2004; 110 (10): 1251-7.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Stamler J, Vaccaro O, Neaton JD et al. for the Multiple Risk Factor Intervention Trial Re-search Group. Diabetes, other risk factors, and 12-year cardiovascular mortality for men screened in the Multiple Risk Factor Intervention Trial. Diabetes Care 1993; 16: 434-44.</mixed-citation><mixed-citation xml:lang="en">Stamler J, Vaccaro O, Neaton JD et al. for the Multiple Risk Factor Intervention Trial Re-search Group. Diabetes, other risk factors, and 12-year cardiovascular mortality for men screened in the Multiple Risk Factor Intervention Trial. Diabetes Care 1993; 16: 434-44.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Parving H.H. Hypertension and diabetes: the scope of the problem. Blood pressure 2001; 10 (Suppl. 2): 25-31.</mixed-citation><mixed-citation xml:lang="en">Parving H.H. Hypertension and diabetes: the scope of the problem. Blood pressure 2001; 10 (Suppl. 2): 25-31.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Мancia G, Grassi G, Zanchetti A. Newonset diabetes and antihypertensive drugs. J Hypertens 2006; 24: 3-10.</mixed-citation><mixed-citation xml:lang="en">Мancia G, Grassi G, Zanchetti A. Newonset diabetes and antihypertensive drugs. J Hypertens 2006; 24: 3-10.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Elliott WJ, Meyer PM. Incident diabetes in clinical trials of antihypertensive drugs: a network metaanalysis. Lancet 2007; 369: 201-7.</mixed-citation><mixed-citation xml:lang="en">Elliott WJ, Meyer PM. Incident diabetes in clinical trials of antihypertensive drugs: a network metaanalysis. Lancet 2007; 369: 201-7.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Mancia G, De Backer G, Dominiczak A et al. 2007 Guidelines for the management of arte-rial hypertension: The Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). Eur Heart J 2007; 28: 1462-536.</mixed-citation><mixed-citation xml:lang="en">Mancia G, De Backer G, Dominiczak A et al. 2007 Guidelines for the management of arte-rial hypertension: The Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). Eur Heart J 2007; 28: 1462-536.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Zusman RM. The role of alpha 1-blockers in combination therapy for hypertension. Int J Clin Pract 2000; 54: 36-40.</mixed-citation><mixed-citation xml:lang="en">Zusman RM. The role of alpha 1-blockers in combination therapy for hypertension. Int J Clin Pract 2000; 54: 36-40.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Verdecchia P, Staessen JA, Angeli F et al. Usual versus tight control of systolic blood pres-sure in non-diabetic patients with hypertension (Cardio-Sis): an open-label randomised trial. Lancet 2009; 374 (9689): 525-33.</mixed-citation><mixed-citation xml:lang="en">Verdecchia P, Staessen JA, Angeli F et al. Usual versus tight control of systolic blood pres-sure in non-diabetic patients with hypertension (Cardio-Sis): an open-label randomised trial. Lancet 2009; 374 (9689): 525-33.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">van Zwieten PA, Blauw GJ, van Brummelen P. Pharmacological profile of anti-hypertensive drugs with serotonin receptor and alpha-adrenoceptor activity. Drugs 1990; 40 (Suppl. 4): 1-8.</mixed-citation><mixed-citation xml:lang="en">van Zwieten PA, Blauw GJ, van Brummelen P. Pharmacological profile of anti-hypertensive drugs with serotonin receptor and alpha-adrenoceptor activity. Drugs 1990; 40 (Suppl. 4): 1-8.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Heran BS, Galm BP, Wright JM. Blood pressure lowering efficacy of alpha blockers for pri-mary hypertension. Cochrane Database Syst Rev 2009; 4: CD004643.</mixed-citation><mixed-citation xml:lang="en">Heran BS, Galm BP, Wright JM. Blood pressure lowering efficacy of alpha blockers for pri-mary hypertension. Cochrane Database Syst Rev 2009; 4: CD004643.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Fozard JR, Mir AK. Are 5HT-receptors involved in the antihypertensive effects of urapidil. Brit J Pharmacol 1987; 90: 24P.</mixed-citation><mixed-citation xml:lang="en">Fozard JR, Mir AK. Are 5HT-receptors involved in the antihypertensive effects of urapidil. Brit J Pharmacol 1987; 90: 24P.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Gross G, Hanft G, Kolassa N. Urapidil and some analogues with hypotensive properties show high affinities for 5-hydroxytryptamine (5HT) binding sites of the 5HT1A-sub-type and for a1-adrenoceptor binding sites. Naunyn-Schmiedeberg. Arch Pharmacol 1987; 336: 597-601.</mixed-citation><mixed-citation xml:lang="en">Gross G, Hanft G, Kolassa N. Urapidil and some analogues with hypotensive properties show high affinities for 5-hydroxytryptamine (5HT) binding sites of the 5HT1A-sub-type and for a1-adrenoceptor binding sites. Naunyn-Schmiedeberg. Arch Pharmacol 1987; 336: 597-601.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Giilis RA, Kellar KJ, Quest JA et al. Experimental studies on the neurocardiovas-cular ef-fects of urapidil. Drugs 1988; 35 (Suppl. 6): 20-33.</mixed-citation><mixed-citation xml:lang="en">Giilis RA, Kellar KJ, Quest JA et al. Experimental studies on the neurocardiovas-cular ef-fects of urapidil. Drugs 1988; 35 (Suppl. 6): 20-33.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Kolassa N, Beller KD, Sanders KH. Involvement of brain 5HT1A-receptors in the hypoten-sive response to urapidil. Am J Cardiol 1989; 64: 7-10D.</mixed-citation><mixed-citation xml:lang="en">Kolassa N, Beller KD, Sanders KH. Involvement of brain 5HT1A-receptors in the hypoten-sive response to urapidil. Am J Cardiol 1989; 64: 7-10D.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Sanders KH, Beller KD, Eltze M et al. Urapidil and some anaglogs with high affinities for serotonin-1A and b1-adrenoceptor binding sites show potent hypotensive activity upon central administration. Current Оpinion Cardiol 1989; 4 (Suppl. 4): S49-55.</mixed-citation><mixed-citation xml:lang="en">Sanders KH, Beller KD, Eltze M et al. Urapidil and some anaglogs with high affinities for serotonin-1A and b1-adrenoceptor binding sites show potent hypotensive activity upon central administration. Current Оpinion Cardiol 1989; 4 (Suppl. 4): S49-55.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Fariello R, Boni E, Corda L, Zaninelli A et al. Influence of a new multifactorial antihyperten-sive on blood pressure and metabolic profile in essential hypertension associated with non-insulin-dependent diabetes mellitus. Eur Heart J 1992; 13 (Suppl. A): 65-9.</mixed-citation><mixed-citation xml:lang="en">Fariello R, Boni E, Corda L, Zaninelli A et al. Influence of a new multifactorial antihyperten-sive on blood pressure and metabolic profile in essential hypertension associated with non-insulin-dependent diabetes mellitus. Eur Heart J 1992; 13 (Suppl. A): 65-9.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Oren S, Turkot S, Paran E, Flandra O et al. Efficacy and tolerability of slow release urapidil (ebrantil) in hypertensive patients with non-insulin dependent diabetes mellitus (NIDDM). J Hum Hypertens 1996; 10: 123-7.</mixed-citation><mixed-citation xml:lang="en">Oren S, Turkot S, Paran E, Flandra O et al. Efficacy and tolerability of slow release urapidil (ebrantil) in hypertensive patients with non-insulin dependent diabetes mellitus (NIDDM). J Hum Hypertens 1996; 10: 123-7.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Goto Y. Effects of sustained-release urapidil on essential hypertension and hyperlipidaemia: a multicenter clinical trial. Curr Ther Res 1992; 51: 870-6.</mixed-citation><mixed-citation xml:lang="en">Goto Y. Effects of sustained-release urapidil on essential hypertension and hyperlipidaemia: a multicenter clinical trial. Curr Ther Res 1992; 51: 870-6.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Ferrara LA, Leonetti G, Fogari R, Mazzola C et al. Urapidil in hypercholesterolemic hyper-tensive patients. Blood Press Suppl 1994; 4: 39-44.</mixed-citation><mixed-citation xml:lang="en">Ferrara LA, Leonetti G, Fogari R, Mazzola C et al. Urapidil in hypercholesterolemic hyper-tensive patients. Blood Press Suppl 1994; 4: 39-44.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Pattenier JW, von Heusinger FC. Effect of urapidil treatment on lipid metabolism in patients with hypertension. Royal Soc Med Int Congr Symp 1992; 196: 61-7.</mixed-citation><mixed-citation xml:lang="en">Pattenier JW, von Heusinger FC. Effect of urapidil treatment on lipid metabolism in patients with hypertension. Royal Soc Med Int Congr Symp 1992; 196: 61-7.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Alijotas-Reig J, Bove-Farre I, De Cabo-Frances F et al. Effectiveness and safety of prehospi-tal urapidil for hypertensive emergencies. Am J Emerg Med 2001; 19: 130-3.</mixed-citation><mixed-citation xml:lang="en">Alijotas-Reig J, Bove-Farre I, De Cabo-Frances F et al. Effectiveness and safety of prehospi-tal urapidil for hypertensive emergencies. Am J Emerg Med 2001; 19: 130-3.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Cherney D, Strans Sh. Management of patients with hypertensive urgencies and emergen-cies. J Gen Intern Med 2002; 17: 937-94.</mixed-citation><mixed-citation xml:lang="en">Cherney D, Strans Sh. Management of patients with hypertensive urgencies and emergen-cies. J Gen Intern Med 2002; 17: 937-94.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Елагин Р.И. Адренергические средства: альфа-адреноблокаторы. Cons. Med. 2003; 7: 1-6.</mixed-citation><mixed-citation xml:lang="en">Елагин Р.И. Адренергические средства: альфа-адреноблокаторы. Cons. Med. 2003; 7: 1-6.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Rosei EA, Salvetti M, Farsang C. Лечение осложненных и неосложненных гипертонических кризов. Актуальные вопросы болезней сердца и сосудов. 2007; 2: 66-8.</mixed-citation><mixed-citation xml:lang="en">Rosei EA, Salvetti M, Farsang C. Лечение осложненных и неосложненных гипертонических кризов. Актуальные вопросы болезней сердца и сосудов. 2007; 2: 66-8.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Liebau H, Wurst W, Harder I, Solleder P. Metabolically neutral therapy of hyper-tension. An open, multicenter, prospective long-term study of the tolerance, safety and effective-ness of ura-pidil. Fortschr Med 1988; 106: 651-4.</mixed-citation><mixed-citation xml:lang="en">Liebau H, Wurst W, Harder I, Solleder P. Metabolically neutral therapy of hyper-tension. An open, multicenter, prospective long-term study of the tolerance, safety and effective-ness of ura-pidil. Fortschr Med 1988; 106: 651-4.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Liebau H, Solleder P, Harder I, Wurst W. Long-term antihypertensive therapy with urapidil. A 3-year open, multicenter trial of tolerance, safety and effectiveness. Fortschr Med 1990; 108: 325-28.</mixed-citation><mixed-citation xml:lang="en">Liebau H, Solleder P, Harder I, Wurst W. Long-term antihypertensive therapy with urapidil. A 3-year open, multicenter trial of tolerance, safety and effectiveness. Fortschr Med 1990; 108: 325-28.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Haerlin R. Treatment of primary and secondary hypertension. Long-term use of urapidil (Ebrantil®). Clinical Trials J 1985; 22: 215-25.</mixed-citation><mixed-citation xml:lang="en">Haerlin R. Treatment of primary and secondary hypertension. Long-term use of urapidil (Ebrantil®). Clinical Trials J 1985; 22: 215-25.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Dooley M, Goa KL. Urapidil. A reappraisal of its use in the management of hypertension. Drugs 1998; 56: 929-55.</mixed-citation><mixed-citation xml:lang="en">Dooley M, Goa KL. Urapidil. A reappraisal of its use in the management of hypertension. Drugs 1998; 56: 929-55.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Zanchetti A. Addition of urapidil or metoprolol to the treatment of hypertensive non-responders to nifedipine monotherapy: efficacy and metabolic effects. Italian Urapidil Study Group. Blood Press Suppl 1995; 3: 38-46.</mixed-citation><mixed-citation xml:lang="en">Zanchetti A. Addition of urapidil or metoprolol to the treatment of hypertensive non-responders to nifedipine monotherapy: efficacy and metabolic effects. Italian Urapidil Study Group. Blood Press Suppl 1995; 3: 38-46.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
