systhiperСистемные гипертензииSystemic Hypertension2075-082X2542-2189LLC «ИнтерМедсервис»systhiper-70Research ArticleСТАТЬИARTICLESРестеноз после коронарного стентирования у больных с метаболическим синдромомДаниловН. М.noemail@neicon.ruГоргадзеТ. Т.noemail@neicon.ruСавченкоА. П.noemail@neicon.ruЧазоваИ. Е.noemail@neicon.ruИнститут кардиологии им. А.Л.Мясникова ФГУ РКНПК Росздрава, МоскваRussian Federation200623122022414750Copyright © Данилов Н.М., Горгадзе Т.Т., Савченко А.П., Чазова И.Е., 20222022Данилов Н.М., Горгадзе Т.Т., Савченко А.П., Чазова И.Е.Данилов Н.М., Горгадзе Т.Т., Савченко А.П., Чазова И.Е.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.syst-hypertension.ru/jour/article/view/70

В последнее время появились достаточно убедительные данные, указывающее на то, что такие факторы, как пониженное высвобождение оксида азота (NO) после проведения перорального теста толерантности к глюкозе (ПТТГ), повышенный уровень лептина, гиперинсулинемия и инсулинорезистентность (ИР), являются важными предикторами развития рестеноза внутри стента у больных ишемической болезнью сердца (ИБС) с нормальными уровнями глюкозы натощак и гликированного гемоглобина. Как известно, именно эти факторы являются основополагающими в структуре формирования метаболического синдрома (МС). Настоящий обзор предполагает, что и ИР, и эндотелиальная дисфункция являются независимыми предикторами рестенозов после коронарного стентирования с использованием непокрытых металлических стентов. Оценка толерантности к глюкозе, секреции инсулина и высвобождения NO после стандартного ПТТГ является важным инструментом в попытке выявить пациентов с высоким риском раннего рестеноза среди больных с МС, подвергающихся эндоваскулярным вмешательствам. Более того, изолированное определение ИР и постнагрузочной гиперинсулинемии хотя и служит важным фактором риска ИБС, является слабым предиктором рестенозов после коронарного стентирования, но становится высоко прогностически значимым при повышенном уровне лептина и сниженном уровне высвобождения NO во время ПТТГ.

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The authors declare that there are no conflicts of interest present.