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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">systhiper</journal-id><journal-title-group><journal-title xml:lang="ru">Системные гипертензии</journal-title><trans-title-group xml:lang="en"><trans-title>Systemic Hypertension</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2075-082X</issn><issn pub-type="epub">2542-2189</issn><publisher><publisher-name>LLC «ИнтерМедсервис»</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">systhiper-743</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>СТАТЬИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ARTICLES</subject></subj-group></article-categories><title-group><article-title>Мочевая кислота и функция эндотелия микроциркуляторного русла у больных на ранних стадиях артериальной гипертонии</article-title><trans-title-group xml:lang="en"><trans-title></trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Атюнина</surname><given-names>И. В.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ощепкова</surname><given-names>Е. В.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Федорович</surname><given-names>А. А.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Дмитриев</surname><given-names>В. А.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гущина</surname><given-names>О. В.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Титов</surname><given-names>В. Н.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Рогоза</surname><given-names>А. Н.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff xml:lang="ru" id="aff-1"><institution>ФГУ Российский кардиологический научно-производственный комплекс Минздрава РФ</institution><country>Russian Federation</country></aff><pub-date pub-type="collection"><year>2012</year></pub-date><pub-date pub-type="epub"><day>09</day><month>02</month><year>2023</year></pub-date><volume>9</volume><issue>2</issue><fpage>29</fpage><lpage>33</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Атюнина И.В., Ощепкова Е.В., Федорович А.А., Дмитриев В.А., Гущина О.В., Титов В.Н., Рогоза А.Н., 2023</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="ru">Атюнина И.В., Ощепкова Е.В., Федорович А.А., Дмитриев В.А., Гущина О.В., Титов В.Н., Рогоза А.Н.</copyright-holder><copyright-holder xml:lang="en">Атюнина И.В., Ощепкова Е.В., Федорович А.А., Дмитриев В.А., Гущина О.В., Титов В.Н., Рогоза А.Н.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.syst-hypertension.ru/jour/article/view/743">https://www.syst-hypertension.ru/jour/article/view/743</self-uri></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Meredith IT, Yeung AC, Weidinger FF et al. Role of impaired endotheliuin-dependent vasodilatioii in iscnemic manifestations of coronary artery disease. Circulation 1993; 87 (SV): 56-6.</mixed-citation><mixed-citation xml:lang="en">Meredith IT, Yeung AC, Weidinger FF et al. Role of impaired endotheliuin-dependent vasodilatioii in iscnemic manifestations of coronary artery disease. Circulation 1993; 87 (SV): 56-6.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Rizzoni D, Porteri E, Castellano M et al. Endothelial dysfunction in hypertension is independent from the etiology and from vascular structure. Hypertension 1998; 31 (pt 2): 335-41.</mixed-citation><mixed-citation xml:lang="en">Rizzoni D, Porteri E, Castellano M et al. Endothelial dysfunction in hypertension is independent from the etiology and from vascular structure. Hypertension 1998; 31 (pt 2): 335-41.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Panza JA, Quyyumi AA, Brush JE, Epstein SE. Abnormal endothelium-dependent vascular relaxation in patients with essential hypertension. N Engl J Med 1990; 323: 22-7.</mixed-citation><mixed-citation xml:lang="en">Panza JA, Quyyumi AA, Brush JE, Epstein SE. Abnormal endothelium-dependent vascular relaxation in patients with essential hypertension. N Engl J Med 1990; 323: 22-7.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Федорович А.А. Функциональное состояние регуляторных механизмов микроциркуляторного кровотока в норме и при артериальной гипертензии по данным лазерной допплеровской флоуметрии. Региональное кровообращение и микроциркуляция. 2010; 9 (33): 49-60.</mixed-citation><mixed-citation xml:lang="en">Федорович А.А. Функциональное состояние регуляторных механизмов микроциркуляторного кровотока в норме и при артериальной гипертензии по данным лазерной допплеровской флоуметрии. Региональное кровообращение и микроциркуляция. 2010; 9 (33): 49-60.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Крупаткин А.И., Сидоров В.В. Лазерная допплеровская флоуметрия микроциркуляции крови. М.: Медицина, 2005; с. 254.</mixed-citation><mixed-citation xml:lang="en">Крупаткин А.И., Сидоров В.В. Лазерная допплеровская флоуметрия микроциркуляции крови. М.: Медицина, 2005; с. 254.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Маколкин В.И., Подзолков В.И., Бранько В.В. и др. Микроциркуляция в кардиологии. М.: 2004; с. 131.</mixed-citation><mixed-citation xml:lang="en">Маколкин В.И., Подзолков В.И., Бранько В.В. и др. Микроциркуляция в кардиологии. М.: 2004; с. 131.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Luscher TF, Noll G. The pathogenesis of cardiovascular disease: role of the endothelium as a target and mediator. Atherosclerosis 1995; (Suppl.) 118: 8190.</mixed-citation><mixed-citation xml:lang="en">Luscher TF, Noll G. The pathogenesis of cardiovascular disease: role of the endothelium as a target and mediator. Atherosclerosis 1995; (Suppl.) 118: 8190.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Van Zwieten PA. Endothelial dysfunction in hypertension. A critical evaluation. Blood Press 1997; (Suppl.) 2: 6770.</mixed-citation><mixed-citation xml:lang="en">Van Zwieten PA. Endothelial dysfunction in hypertension. A critical evaluation. Blood Press 1997; (Suppl.) 2: 6770.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Vanhoutte PM. Endothelial dysfunction in hypertension J Hypertens 1996; (Suppl.) 14 (5): 8393.</mixed-citation><mixed-citation xml:lang="en">Vanhoutte PM. Endothelial dysfunction in hypertension J Hypertens 1996; (Suppl.) 14 (5): 8393.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Boulanger C, Vanhoutte PM. The role of the endothelium in the regulation of vasomotor activity. Arch Mal Coeur Vaiss 1991; 84 (Spec.) 1: 3544.</mixed-citation><mixed-citation xml:lang="en">Boulanger C, Vanhoutte PM. The role of the endothelium in the regulation of vasomotor activity. Arch Mal Coeur Vaiss 1991; 84 (Spec.) 1: 3544.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Van Zwieten PA. Endothelial dysfunction in hypertension. A critical evaluation. Blood Press 1997; (Suppl.) 2: 6770.</mixed-citation><mixed-citation xml:lang="en">Van Zwieten PA. Endothelial dysfunction in hypertension. A critical evaluation. Blood Press 1997; (Suppl.) 2: 6770.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Zoccali C, Maio R, Mallamaci F et al. Uric acid and endothelial dysfunction in essential hypertension. J Am Soc Nephrol 2006; 17: 1466-7.</mixed-citation><mixed-citation xml:lang="en">Zoccali C, Maio R, Mallamaci F et al. Uric acid and endothelial dysfunction in essential hypertension. J Am Soc Nephrol 2006; 17: 1466-7.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Khosla UM, Zharikov S, Finch JL et al. Hyperuricemia induces endothelial dysfunction. Kidney Int 2005; 67: 1739-42.</mixed-citation><mixed-citation xml:lang="en">Khosla UM, Zharikov S, Finch JL et al. Hyperuricemia induces endothelial dysfunction. Kidney Int 2005; 67: 1739-42.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Verdechia P, Schilaci G, Reboldi G. Relation between serum uric acid and risk of cardiovascular disease in essential hypertension. The PIUMA study. Hypertension 2000; 36: 1072-8.</mixed-citation><mixed-citation xml:lang="en">Verdechia P, Schilaci G, Reboldi G. Relation between serum uric acid and risk of cardiovascular disease in essential hypertension. The PIUMA study. Hypertension 2000; 36: 1072-8.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Faig DL, Johnson RJ. Hyperuricemia in childhood primary hypertension. Hypertension 2003; 42: 247-52.</mixed-citation><mixed-citation xml:lang="en">Faig DL, Johnson RJ. Hyperuricemia in childhood primary hypertension. Hypertension 2003; 42: 247-52.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Band FN, McGee DL, Kennel WB. Hyperuricemia as a risk factor of coronary heart disease: the Framinghem Heart Study. Am J Epidemiology 1985; 121 (1): 11-8.</mixed-citation><mixed-citation xml:lang="en">Band FN, McGee DL, Kennel WB. Hyperuricemia as a risk factor of coronary heart disease: the Framinghem Heart Study. Am J Epidemiology 1985; 121 (1): 11-8.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Fang J, Alderman MN. Serum uric acid and cardiovascular mortality: The NHANES I Epidemiologic Follow-up study 1971-1992. National Health and nutrition Examination survey. Am Med Assoc 2000; 238; 2404-10.</mixed-citation><mixed-citation xml:lang="en">Fang J, Alderman MN. Serum uric acid and cardiovascular mortality: The NHANES I Epidemiologic Follow-up study 1971-1992. National Health and nutrition Examination survey. Am Med Assoc 2000; 238; 2404-10.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Meisinger C, Koenig W, Baumert J, Doring A. Uric Acid Levels Are Associated With All-Cause and Cardiovascular Disease Mortality Independent of Systemic Inflammation in Men From the General Population. The MONICA/KORA Cohort Study. Arterioscler Thromb Vasc Biol 2008; 28: 1186-92.</mixed-citation><mixed-citation xml:lang="en">Meisinger C, Koenig W, Baumert J, Doring A. Uric Acid Levels Are Associated With All-Cause and Cardiovascular Disease Mortality Independent of Systemic Inflammation in Men From the General Population. The MONICA/KORA Cohort Study. Arterioscler Thromb Vasc Biol 2008; 28: 1186-92.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Методические аспекты применения метода лазерной допплеровской флоуметрии. Чуян Е.Н., Трибрат Н.С. Серия Биология; Химия 2008; 21 (60); 2: 156-71.</mixed-citation><mixed-citation xml:lang="en">Методические аспекты применения метода лазерной допплеровской флоуметрии. Чуян Е.Н., Трибрат Н.С. Серия Биология; Химия 2008; 21 (60); 2: 156-71.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Stefanovska A, Bracic M, Kvernmo HD. Wavelet analysis of oscillations in peripheral blood circulation measured by Doppler technique. IEEE Trans Biomed Eng 1999; 46: 1230-9.</mixed-citation><mixed-citation xml:lang="en">Stefanovska A, Bracic M, Kvernmo HD. Wavelet analysis of oscillations in peripheral blood circulation measured by Doppler technique. IEEE Trans Biomed Eng 1999; 46: 1230-9.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Klijn E, Lagrand WK et al. The microcirculation in health and critical disease. Prog Cardiovasc Dis 2008; 51: 161-70.</mixed-citation><mixed-citation xml:lang="en">Klijn E, Lagrand WK et al. The microcirculation in health and critical disease. Prog Cardiovasc Dis 2008; 51: 161-70.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Stroes ES, Koomans НА, de Bmin TW, Rabelink ТJ. Vascular function in the forearm of hypercholesterolaemic patients off and оn lipid-lowering medication. Lancet 1995; 346: 467-71.</mixed-citation><mixed-citation xml:lang="en">Stroes ES, Koomans НА, de Bmin TW, Rabelink ТJ. Vascular function in the forearm of hypercholesterolaemic patients off and оn lipid-lowering medication. Lancet 1995; 346: 467-71.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Annuk M, Zilmer M, Lind L et al. Oxidative stress and endothelial function in chronic renal failure. J Am Soc Nephrol 2001; 12: 2747-52.</mixed-citation><mixed-citation xml:lang="en">Annuk M, Zilmer M, Lind L et al. Oxidative stress and endothelial function in chronic renal failure. J Am Soc Nephrol 2001; 12: 2747-52.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Johnson RJ, Kang D-H, Feig D et al. Is there a pathogenic role for uric acid in hypertension and cardiovascular and renal disease? Hypertension 2003; 41: 1183-90.</mixed-citation><mixed-citation xml:lang="en">Johnson RJ, Kang D-H, Feig D et al. Is there a pathogenic role for uric acid in hypertension and cardiovascular and renal disease? Hypertension 2003; 41: 1183-90.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Corry DB, Eslami P, Yamamoto K et al. Uric acid stimulates vascular smooth muscle cell proliferation and oxidative stress via the vascular renin-angiotensin system. J. Hypertension 2008; 26 (2): 269-75.</mixed-citation><mixed-citation xml:lang="en">Corry DB, Eslami P, Yamamoto K et al. Uric acid stimulates vascular smooth muscle cell proliferation and oxidative stress via the vascular renin-angiotensin system. J. Hypertension 2008; 26 (2): 269-75.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Sautin YY, Nakagawa T, Zharikov S et al. Adverse effects of the ckassical antioxidant uric acid in adypocites: NAD-PH oxidase-mediated oxidative/nitrosative stress. Am J Physiol Cell Physiol 2007; 293: 584-96.</mixed-citation><mixed-citation xml:lang="en">Sautin YY, Nakagawa T, Zharikov S et al. Adverse effects of the ckassical antioxidant uric acid in adypocites: NAD-PH oxidase-mediated oxidative/nitrosative stress. Am J Physiol Cell Physiol 2007; 293: 584-96.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Celermajer DS, Sorensen KE, Gooch VM et al. Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis. Lancet 1992; 340: 1111-15.</mixed-citation><mixed-citation xml:lang="en">Celermajer DS, Sorensen KE, Gooch VM et al. Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis. Lancet 1992; 340: 1111-15.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Moncoda S, Radomski MW, Palmer RMJ. Endothelium-derived relaxing factor: identification of nitric oxide and role in the control of vascular tone and platelet function. Biochem. Pharmacology 1988; 37: 2495-2501.</mixed-citation><mixed-citation xml:lang="en">Moncoda S, Radomski MW, Palmer RMJ. Endothelium-derived relaxing factor: identification of nitric oxide and role in the control of vascular tone and platelet function. Biochem. Pharmacology 1988; 37: 2495-2501.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Mazzali M, Hughes J, Kim Yooh-Goo et al. Elevated uric acid increases blood pressure in the rat by a novel crystal-independent mechanism. Hypertension 2001; 38: 1101-06.</mixed-citation><mixed-citation xml:lang="en">Mazzali M, Hughes J, Kim Yooh-Goo et al. Elevated uric acid increases blood pressure in the rat by a novel crystal-independent mechanism. Hypertension 2001; 38: 1101-06.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Бойцов С.А., Федорович А.А., Рогоза А.Н. Основные параметры микроциркуляторного кровотока в норме по данным лазерной допплеровской флоуметрии. Национальный медико-хирургический центр им. Н.И.Пирогова. Научные труды. Москва, РАЕН: 2009; 2: 86-101.</mixed-citation><mixed-citation xml:lang="en">Бойцов С.А., Федорович А.А., Рогоза А.Н. Основные параметры микроциркуляторного кровотока в норме по данным лазерной допплеровской флоуметрии. Национальный медико-хирургический центр им. Н.И.Пирогова. Научные труды. Москва, РАЕН: 2009; 2: 86-101.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
