The urgency of the problem of comorbidity of peptic ulcer disease and arterial hypertension is due to their high prevalence in the population, the commonality of some pathogenetic mechanisms and the difficulties of pharmacotherapy, when treatment of one pathology can negatively affect the course of another. The combination of peptic ulcer disease and arterial hypertension poses serious diagnostic and therapeutic challenges for the clinician, requiring a comprehensive and measured approach. Numerous epidemiological studies confirm that peptic ulcer disease and arterial hypertension often occur in the same patient. This association is not random and can be explained by both common risk factors (psychosocial stress, smoking, poor diet, etc.) and direct pathophysiological interactions. The presence of hypertension in a patient with peptic ulcer disease aggravates its course, increases the risk of complications (bleeding), and the need for constant use of antihypertensive and antiplatelet drugs dictates the need for a special gastroprotective strategy. This article is devoted to a literature review of current data on pathogenetic relationships, drug interactions and optimal strategies for managing patients with this comorbidity.