Gender differences renin-angiotensin-aldosterone system and its relation to humoral factors in patients with arterial hypertension

Aim. Explore gender characteristics of the renin-angiotensin-aldosterone system (RAAS), to assess the state of the RAAS relationship with the level of female sex hormones, aldosterone, plasma renin activity in patients with arterial hypertension (AH) in postmenopausal women.Materials and methods. The study included 35 patients with hypertension 1-3-th degree, the average age 56.8±6.9 years. The control group included 21 healthy people with a normal body mass index (BMI). Each of these groups was divided into subgroups by gender: group IA included healthy men (n=10), group IB - healthy women (n=11), group IIA - men with hypertension (n=17), group IIB - Women with hypertension (n=18). Evaluation was carried out with a hormonal status determining levels of estradiol, testosterone, aldosterone, plasma renin activity in the serum.Results. Aldosterone concentration in group IIB was 169.8±109.9 pg/ml and was significantly higher (p<0.05) than in the group IIA 98.1±47.4 pg/ml. In women with hypertension was observed in more than two-fold increase in renin than men with hypertension (3.8±2.2 vs 1.5±1.3). Statistically significant differences in hormonal profile manifested in the form of a lower concentration of testosterone in the group IB compared to the group IA (0.2±1.08 vs 6.8±2.7), p<0,05. In the group of patients with hypertension (group IIB) was detected with a high concentration of testosterone (9.5 times) when compared with a control group of women (group IB).Conclusion. Hypertensive patients were found gender differences in the state of the RAAS with a higher concentration of aldosterone and renin in postmenopausal women than in men of comparable groups. Testosterone levels in women with hypertension was significantly higher than the values in comparison with the control group of women.

hypertension, men, women, aldosterone, renin, testosterone, postmenopaus

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