CONNECTION BETWEEN URIC ACID AND SCARDIVASCULAR RISK FACTORS IN HYPERTENSIVE PATIENTS.
Natavan Zakir kyzy Musaeva,
Elena Vladimirovna Oshchepkova,
Anna Vladimirovna Aksenova,
Timur Maratovich Gurtsiev,
Irina Evgen'evna Chazova Abstract
The aim of the research is to analyze correlations between UA and cardiovascular risk factors (CV RF) (age, BMI, waist circumference (WC), total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) levels, glucose) and GFR in outpatient care hypertensive patients. The research was based on the data of 1285 ambulatory patients from the national register of Hypertension. Hyperuricemia (HU) was detected in 28,4% of cases. A positive correlation was established between UA and WC, BMI; negative – between UA and kidney function deterioration (based on GFR). It was stated that diuretic therapy and smoking are associated with the increase in UA serum levels. The study of CV RF frequency in patients with hypertension (H) and HU concluded that 80% had more than 1 additional RF; combination of ≥3 RF occurred in males significantly more often than in females.
Acquired data proves that UA is closely related to disturbance in metabolic factors, kidney function and diuretic therapy admission, which makes it essential to control its levels in hypertensive patients, as well as to use measures approved by the modern guidelines to decrease UA in patients with HU.
About the Authors
Natavan Zakir kyzy MusaevaРоссия
Clinical Resident
Elena Vladimirovna Oshchepkova
Россия
Dr. Sci. (Med.), Professor, Chief Researcher, Department of Hypertension, Institute of Clinical Cardiology named after A.L. Myasnikov.
Anna Vladimirovna Aksenova
Россия
Cand. Sci. (Med.), Research Scientist, Department of Hypertension, Institute of Clinical Cardiology named after A.L. Myasnikov, E.I.
Timur Maratovich Gurtsiev
Россия
Clinical Resident
Irina Evgen'evna Chazova
Россия
Dr. Sci. (Med.), Professor, Full Member of the Russian Academy of Sciences, Head of the Department of Hypertension Head of the Department of Hypertension, A.L. Myasnikov Research Institute of Clinical Cardiology, Deputy Director General for Scientific and Expert Work of the E.I. Chazov National Medical Research Center of Cardiology
References
1. Биологическая химия. Учебник для вузов. Под редакцией чл.-корр. РАН, проф. Е.С. Северина – М.: ГЭОТАР-Медиа, 2011. – 624 с.: ил.
2. Чазова И.Е., Жернакова Ю.В., Кисляк О.А., Подзолков В.И., Ощепкова Е.В., Миронова О.Ю., Блинова Н.В. Консенсус по ведению пациентов с гиперурикемией и высоким сердечно-сосудистым риском: 2022. Системные гипертензии. 2022;19(1):5-22. https://doi.org/10.38109/2075-082X-2022-1-5-22
3. Stewart DJ, Langlois V, Noone D. Hyperuricemia and hypertension: links and risks. Integr Blood Press Control. (2019) 12:43–62. doi: 10.2147/IBPC.S184685
4. Shalnova S.A., Deev A.D., Artamonov G.V., Duplyakov D.V., Efanov A.Yu., Zhernakova Yu.V., Konradi A.O., Libis R.A., Muromtseva G.A., Nedogoda S.V., Oschepkova E.V., Romanchuk S.V., Rotar O.P., Titov V.N., Toguzova Z.A., Trubacheva I.A., Furmenko G.I., Shlyakhto E.V., Boytsov S.A. HYPERURICEMIA AND ITS CORRELATES IN THE RUSSIAN POPULATION (RESULTS OF ESSE-RF EPIDEMIOLOGICAL STUDY). Rational Pharmacotherapy in Cardiology. 2014;10(2):153-159. (In Russ.)
5. Elfishawi MM, Zleik N, Kvrgic Z, Michet CJ Jr, Crowson CS, Matteson EL, Bongartz T. The Rising Incidence of Gout and the Increasing Burden of Comorbidities: A Population-based Study over 20 Years. J Rheumatol. 2018 Apr;45(4):574-579. doi: 10.3899/jrheum.170806. Epub 2017 Dec 15. PMID: 29247151; PMCID: PMC5880714.
6. Del Pinto R, Viazzi F, Pontremoli R, Ferri C, Carubbi F, Russo E. The URRAH study. Panminerva Med. 2021 Dec;63(4):416-423. doi: 10.23736/S0031-0808.21.04357-3. Epub 2021 Mar 26. PMID: 33765764.
7. Ruocco G, Palazzuoli A. Hyperuricemia in US Population with Heart Failure: Causal or Incidental Bystander? Cardiorenal Med. 2019;9(6):341-343. doi: 10.1159/000503058. Epub 2019 Oct 23. PMID: 31645036.
8. Chazova I.E., Zhernakova Ju.V., Kisliak O.A. et al. Consensus on patients with hyperuricemia and high cardiovascular risk treatment. Systemic Hypertension. 2019; 16
9. Shalnova S.A., Deev A.D., Artamonov G.V., Duplyakov D.V., Efanov A.Yu., Zhernakova Yu.V., Konradi A.O., Libis R.A., Muromtseva G.A., Nedogoda S.V., Oschepkova E.V., Romanchuk S.V., Rotar O.P., Titov V.N., Toguzova Z.A., Trubacheva I.A., Furmenko G.I., Shlyakhto E.V., Boytsov S.A. HYPERURICEMIA AND ITS CORRELATES IN THE RUSSIAN POPULATION (RESULTS OF ESSE-RF EPIDEMIOLOGICAL STUDY). Rational Pharmacotherapy in Cardiology. 2014;10(2):153-159. (In Russ.)
10. Borghi C, Domienik-Karłowicz J, Tykarski A, et al. Expert consensus for the diagnosis and treatment of patient with hyperuricemia and high cardiovascular risk: 2021 update. Cardiol J. 2021;28(1):1-14. doi:10.5603/CJ.a2021.0001
11. Zhu Y, Pandya BJ, Choi HK. Prevalence of gout and hyperuricemia in the US general population: the National Health and Nutrition Examination Survey 2007–2008. Arthritis Rheum. 2011;63(10):3136–3141. doi: 10.1002/art.30520.
12. Chen-Xu M, Yokose C, Rai SK, et al. Hyperuricemia in the United States and Decadal Trends: The National Health and Nutrition Examination Survey, 2007 –2016. Arthritis Rheumatol. 2019;71(6):991–999. doi: 10.1002/art.40807.
13. Zhu Y, Pandya BJ, Choi HK. Prevalence of gout and hyperuricemia in the US general population: the National Health and Nutrition Examination Survey 2007-2008. Arthritis Rheum. 2011;63(10):3136-3141. doi:10.1002/art.30520
14. Chen-Xu M, Yokose C, Rai SK, Pillinger MH, Choi HK. Contemporary Prevalence of Gout and Hyperuricemia in the United States and Decadal Trends: The National Health and Nutrition Examination Survey, 2007-2016. Arthritis Rheumatol. 2019;71(6):991-999. doi:10.1002/art.40807
15. Borghi C, Domienik-Karłowicz J, Tykarski A, Widecka K, Filipiak KJ, Jaguszewski MJ, Narkiewicz K, Mancia G. Expert consensus for the diagnosis and treatment of patient with hyperuricemia and high cardiovascular risk: 2021 update. Cardiol J. 2021;28(1):1-14. doi: 10.5603/CJ.a2021.0001. Epub 2021 Jan 13. PMID: 33438180; PMCID: PMC8105060.
16. Grayson PC, Kim SY, LaValley M, et al. Hyperuricemia and incident hypertension: a systematic review and meta-analysis. Arthritis Care Res (Hoboken) 2011;63(1):102–110. doi: 10.1002/acr.20344
17. Shalnova S.A., Deev A.D., Artamonov G.V., Duplyakov D.V., Efanov A.Yu., Zhernakova Yu.V., Konradi A.O., Libis R.A., Muromtseva G.A., Nedogoda S.V., Oschepkova E.V., Romanchuk S.V., Rotar O.P., Titov V.N., Toguzova Z.A., Trubacheva I.A., Furmenko G.I., Shlyakhto E.V., Boytsov S.A. HYPERURICEMIA AND ITS CORRELATES IN THE RUSSIAN POPULATION (RESULTS OF ESSE-RF EPIDEMIOLOGICAL STUDY). Rational Pharmacotherapy in Cardiology. 2014;10(2):153-159. (In Russ.)
18. Shirasawa T, Ochiai H, Yoshimoto T, et al. Cross-sectional study of associations between normal body weight with central obesity and hyperuricemia in Japan [published correction appears in BMC Endocr Disord. 2020 Feb 21;20(1):26]. BMC Endocr Disord. 2020;20(1):2. Published 2020 Jan 6. doi:10.1186/s12902-019-0481-1
19. Е.В Ощепкова, П.Я. Довгалевский, В.И. Гриднев. Регистр артериальной гипертонии в первичном звене здравоохранения. Государство и медицина. АтмосферА. Кардиология 3, 2006. Стр.43-44
20. Ощепкова Е.В., Довгалевский П.Я., Гриднев В.И., Посненкова О.М., Киселев А.Р., Дмитриев В.А., Попова Ю.В., Волкова Е.Н. Структура первичных элементов базы данных российского регистра больных артериальной гипертонией, ишемической болезнью сердца и хронической сердечной недостаточностью. Кардио-ИТ 2014; 1: 0202. DOI: 10.15275/cardioit.2014.0202
21. Stevens PE, Levin A; Kidney Disease: Improving Global Outcomes Chronic Kidney Disease Guideline Development Work Group Members. Evaluation and management of chronic kidney disease: synopsis of the kidney disease: improving global outcomes 2012 clinical practice guideline. Ann Intern Med. 2013;158(11):825-830. doi:10.7326/0003-4819-158-11-201306040-00007
22. Front. Cardiovasc. Med., 11 January 2022 Sec. Hypertension Volume 8 – 2021 https://doi.org/10.3389/fcvm.2021.751089
23. Kuwabara M, Kuwabara R, Niwa K, Hisatome I, Smits G, Roncal-Jimenez CA, MacLean PS, Yracheta JM, Ohno M, Lanaspa MA, Johnson RJ, Jalal DI. Different Risk for Hypertension, Diabetes, Dyslipidemia, and Hyperuricemia According to Level of Body Mass Index in Japanese and American Subjects. Nutrients. 2018 Aug 3;10(8):1011. doi: 10.3390/nu10081011. PMID: 30081468; PMCID: PMC6115805.
24. Wang YY, Li L, Cui J, Yin F, Yang F, Yuan DM, Xin HL, Zhang L, Gao WG, Sun JP. Associations between anthropometric parameters (body mass index, waist circumference and waist to hip ratio) and newly diagnosed hyperuricemia in adults in Qingdao, China: A cross-sectional study. Asia Pac J Clin Nutr. 2020;29(4):763-770. doi: 10.6133/apjcn.202012_29(4).0011. PMID: 33377370.
25. Obermayr RP, Temml C, Gutjahr G, Knechtelsdorfer M, Oberbauer R, Klauser-Braun R. Elevated uric acid increases the risk for kidney disease. J Am Soc Nephrol. 2008 Dec;19(12):2407-13. doi: 10.1681/ASN.2008010080. Epub 2008 Sep 17. PMID: 18799720; PMCID: PMC2588108.
26. Shalnova S.A., Deev A.D., Artamonov G.V., Duplyakov D.V., Efanov A.Yu., Zhernakova Yu.V., Konradi A.O., Libis R.A., Muromtseva G.A., Nedogoda S.V., Oschepkova E.V., Romanchuk S.V., Rotar O.P., Titov V.N., Toguzova Z.A., Trubacheva I.A., Furmenko G.I., Shlyakhto E.V., Boytsov S.A. HYPERURICEMIA AND ITS CORRELATES IN THE RUSSIAN POPULATION (RESULTS OF ESSE-RF EPIDEMIOLOGICAL STUDY). Rational Pharmacotherapy in Cardiology. 2014;10(2):153-159. (In Russ.)
27. Гиперурикемия и сахарный диабет. РМЖ. Медицинское обозрение. 2019;3(1(I)):20-24.
28. Shalnova S.A., Deev A.D., Artamonov G.V., Duplyakov D.V., Efanov A.Yu., Zhernakova Yu.V., Konradi A.O., Libis R.A., Muromtseva G.A., Nedogoda S.V., Oschepkova E.V., Romanchuk S.V., Rotar O.P., Titov V.N., Toguzova Z.A., Trubacheva I.A., Furmenko G.I., Shlyakhto E.V., Boytsov S.A. HYPERURICEMIA AND ITS CORRELATES IN THE RUSSIAN POPULATION (RESULTS OF ESSE-RF EPIDEMIOLOGICAL STUDY). Rational Pharmacotherapy in Cardiology. 2014;10(2):153-159. (In Russ.)
29. Chen-Xu M, Yokose C, Rai SK, Pillinger MH, Choi HK. Contemporary Prevalence of Gout and Hyperuricemia in the United States and Decadal Trends: The National Health and Nutrition Examination Survey, 2007-2016. Arthritis Rheumatol. 2019;71(6):991-999. doi:10.1002/art.40807
30. «ИЗУЧЕНИЕ СОДЕРЖАНИЯ МОЧЕВОЙ КИСЛОТЫ СЫВОРОТКИ КРОВИ И МОЧИ В СОПОСТАВЛЕНИИ С СОСТОЯНИЕМ ОРГАНОВ-МИШЕНЕЙ (СОСУДЫ, ПОЧКИ) У БОЛЬНЫХ ГИПЕРТОНИЧЕСКОЙ БОЛЕЗНЬЮ НА РАННИХ СТАДИЯХ ЗАБОЛЕВАНИЯ», диссертация на соискание ученой степени к.м.н., ИНСТИТУТ КЛИНИЧЕСКОЙ КАРДИОЛОГИИ ИМ. А.Л. МЯСНИКОВА ФГУ «РОССИЙСКИЙ КАРДИОЛОГИЧЕСКИЙ НАУЧНО-ПРОИЗВОДСТВЕННЫЙ КОМПЛЕКС» МИНИСТЕРСТВА ЗДРАВООХРАНЕНИЯ И СОЦИАЛЬНОГО РАЗВИТИЯ РОССИЙСКОЙ ФЕДЕРАЦИИ. Гущина О.В, 2011 г.
31. Bazalar-Palacios, J., Jaime Miranda, J., Carrillo-Larco, R.M. et al. Aggregation and combination of cardiovascular risk factors and their association with 10-year all-cause mortality: the PERU MIGRANT Study. BMC Cardiovasc Disord 21, 582 (2021). https://doi.org/10.1186/s12872-021-02405-8
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For citations:
Musaeva N.Z., Oshchepkova E.V., Aksenova A.V., Gurtsiev T.M., Chazova I.E. CONNECTION BETWEEN URIC ACID AND SCARDIVASCULAR RISK FACTORS IN HYPERTENSIVE PATIENTS. Systemic Hypertension. 2023;20(3).
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