Resistin as an independent marker of vascular stiffness in patients with arterial hypertension

The aim of the study: to investigate the association of plasma resistin concentration with the vascular stiffness index CAVI and to identify factors associated with increased vascular stiffness in patients with arterial hypertension (AH).

Materials and methods. 72 patients (34 men and 38 women) with AH aged 48 to 84 years were included in the study. Type 2 diabetes mellitus (T2DM) was diagnosed in 16 (22.2%) patients. Together with the standard investigations, all patients underwent determination of plasma resistin concentration and measurement of vascular stiffness based on the CAVI index.

Results. All patients with AH were divided into 2 groups: patients with increased vascular stiffness (CAVI≥9) – 32 people (group 1) and patients with normal vascular stiffness (CAVI<9) – 40 people (group 2). A significantly higher concentration of resistin in blood plasma was observed in patients of group 1 – 6.23 [4.99; 8.35] ng/ml compared to group 2 – 4.1 [3.8; 5.58] ng/ml, p=0.036. Univariate linear regression analysis revealed a direct relationship between plasma resistin concentration and CAVI index (beta1=0.34; SD=0.08; p<0.001). According to multivariate regression analysis, independent markers of increased vascular stiffness in patients with AH were: age (OR=1.19, CI=1.06-1.30), T2DM (OR=2.39, CI=1.16-5.99), plasma resistin concentration (OR=1.46, CI=1.09-2.27), p<0.05. Resistin level more than 4.95 ng/ml with sensitivity of 65.2% and specificity of 56.5% allows to diagnose increased arterial stiffness in patients with AH (AUC=0.673, p<0.05).

Conclusion. Independent markers of vascular stiffness in patients with AH are not only age and T2DM, but also a plasma resistin concentration of more than 4.95 ng/ml.

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