The prevalence of renal dysfunction in arterial hypertension (in the framework of the ESSE-RF study)
Abstract
Objective. To study the prevalence of renal dysfunction, its relation with arterial hypertension and metabolic risk factors.Materials and methods. Data from the ESSE-RF study from 10 regions of the Russian Federation are presented. Renal dysfunction was assessed on the basis of the calculation of glomerular filtration rate (GFR). GFR calculation was conducted on the Chronic Kidney Disease Epidemiology Collaboration (GFR-EPI).Results. The study reveals a high prevalence of GFR decline in the population studied (76.8% in women and 23.2% in men). More unfavorable situation was found among the patients with hypertensionand in patients with hypertension and impaired glucose metabolism or diabetes mellitus, in which the prevalence of decrease GFR was higher than in patients without hypertension and without impaired glucose metabolism or diabetes mellitus.Conclusion. Prevalence of renal dysfunction among the Russian population is defined. Associations of reduction in glomerular filtration rate with cardiometabolic risk factors are revealed.
About the Authors
E. V. Oshchepkova
A.L.Myasnikov Institute of Clinical Cardiology, Russian Cardiology Research and Production Complex of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Iu. A. Dolgusheva
A.L.Myasnikov Institute of Clinical Cardiology, Russian Cardiology Research and Production Complex of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Iu. V. Zhernakova
A.L.Myasnikov Institute of Clinical Cardiology, Russian Cardiology Research and Production Complex of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
I. E. Chazova
A.L.Myasnikov Institute of Clinical Cardiology, Russian Cardiology Research and Production Complex of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
S. A. Shal'nova
State Research Center for Preventive Medicine of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
E. B. Iarovaia
A.L.Myasnikov Institute of Clinical Cardiology, Russian Cardiology Research and Production Complex of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
O. P. Rotar'
V.A.Almazov Northwestern federal medical research center of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
A. O. Konradi
V.A.Almazov Northwestern federal medical research center of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
S. A. Boitsov
State Research Center for Preventive Medicine of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
References
1. Чазова И.Е., Жернакова Ю.В., Ощепкова Е.В. и др. Распространенность ФР сердечно - сосудистых заболеваний в российской популяции больных артериальной гипертонией. Кардиология. 2014; 10: 4-12.
2. Чазова И.Е., Ощепкова Е.В. Итоги реализации Федеральной целевой программы по профилактике и лечению артериальной гипертензии в России в 2002- 2012 гг. Вестн. Российской академии медицинских наук. 2013; 2: 4-11.
3. Henry R.M, Kostense P.J, Bos G et al. Mild renal insufficiency is associated with increased cardiovascular mortality: the Hoorn Study. Kidney Int 2002; 62: 1402-7.
4. Brantsma A.H, Bakker S.J. Hillege H.L et al. Urinary albumin excretion and its relation with C-reactive protein and the metabolic syndrome in the prediction of type 2 diabetes. Diabetes Care 2005; 28 (10): 2525-30.
5. Klausen K.P, Scharling H, Jensen G et al. New definition of microalbuminuria in hypertensive subjects: association with incident coronary heart disease and death. Hypertension 2005; 46 (1): 33-7.
6. Schmieder R.E, Schrader J, Zidek W et al. Low - grade albuminuria and cardiovascular risk: what is the evidence? Clin Res Cardiol 2007; 96 (5): 247-57.
7. Hallan S, Asberg A, Lindberg M et al. Validation of the Modification of Diet in Renal Disease formula for estimating GFR with special emphasis on calibration of the serum creatinine assay. Am J Kidney Dis 2004; 44 (1): 84-93.
8. Ibrahim S, Rashid L, Darai M. Modification of diet in renal disease equation underestimates glomerular filtration rate in egyptian kidney donors. Exp Clin Transplant 2008; 6 (2): 144-8.
9. Kim M-J, Lim N-K, Park H-Y. Relationship between prehypertension and chronic kidney disease in middle - aged people in Korea: the Korean genome and epidemiology study. BMC Public Health 2012; 12: 960.
10. Coresh J, Selvin E, Stevens L.A et al. Prevalence of chronic kidney disease in the United States. JAMA 2007; 298: 2038-47.
11. Chadban S.J, Briganti E.M, Kerr P.G et al. Prevalence of kidney damage in Australian adults: The Aus Diab kidney study. J Am Soc Nephrol 2003, 14 (7 Suppl. 2): 131-8.
12. Asia pacific Cohort Studies Collaboration. The effects of diabetes on the risk of major cardiovascular diseases and death in the Asia-Pacific region. Diabetes Care 2003; 26: 360-6.
13. Klag M.J, Whelton P.K, Randall B.L et al. Endstage renal disease in African-American and white men. 16-year MRFIT findings. JAMA 1997; 277 (16): 1293-8.
14. Chen J, Muntner P, Hamm L et al. The metabolic syndrome and chronic kidney disease in U.S. adults. Ann Intern Med 2004; 140 (3): 167-74.
15. Palaniappan L, Carnethon M, Fortmann S. Association between microalbuminuria and the metabolic syndrome: NHANES III. Am J Hypertens 2003; 16 (11 Pt. 1): 952-8.
16. Despres J. Abdominal obesity: the most prevalent cause of the metabolic syndrome and related cardiometabolic risk. Eur Heart J 2006; 8 (Suppl. B): 4-12.
17. Vassalotti J.A, Stevens L.A, Levey A.S. Testing for chronic kidney disease: a position statement from the National Kidney Foundation. Am J Kidney Dis 2007; 50 (2): 169-80.
Review
For citations:
Oshchepkova E.V., Dolgusheva I.A., Zhernakova I.V., Chazova I.E., Shal'nova S.A., Iarovaia E.B., Rotar' O.P., Konradi A.O., Boitsov S.A. The prevalence of renal dysfunction in arterial hypertension (in the framework of the ESSE-RF study). Systemic Hypertension. 2015;12(3):19-24. (In Russ.)
Views:
119
Email this article 