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Survival of patients with pulmonary arterial hypertension during therapy PAH-specific drugs

Abstract

Pulmonary arterial hypertension (PAH) is a life threatening syndrome, which is characterized by a progressive increase in pulmonary vascular resistance (PVR), medium pulmonary artery pressure and functional disorders and morphological changes of pulmonary arteries. Despite the relative abundance of PAH-specific drugs, the choice of a suitable agent for the treatment of a particular patient remains challenging. One of the most important parameters measured in clinical studies is patient survival or, in some cases, mortality. Survival or mortality as secondary or components of the primary endpoint one way or another has been studied in clinical trials of drugs for the treatment of PAH. For tablets drugs for the treatment of some forms of PAH (sildenafil, riociguat, bosentan, macitentan, ambrisentan) currently available data studies, which studied the survival.

About the Authors

D. Yu. Platonov
Regional Clinical Hospital; Tver State Medical University of the Ministry of Health of the Russian Federation
Russian Federation


N. A. Tsareva
Research Institute of Pulmonology of FMBA of Russia; I.M.Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation
Russian Federation


S. N. Avdeev
Research Institute of Pulmonology of FMBA of Russia; I.M.Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation
Russian Federation


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Review

For citations:


Platonov D.Yu., Tsareva N.A., Avdeev S.N. Survival of patients with pulmonary arterial hypertension during therapy PAH-specific drugs. Systemic Hypertension. 2017;14(3):58-64.

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ISSN 2075-082X (Print)
ISSN 2542-2189 (Online)