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Interaction of antihypertensive drugs and rosuvastatin: focus on safety, efficiency and prospects

https://doi.org/10.26442/2075-082X_14.3.79-83

Abstract

Arterial hypertension and dyslipidemia is a very frequent comorbid condition. Arterial hypertension and dyslipidemia are combined in 40-70% of patients. The statins is the basic drug in primary and secondary prevention of cardiovascular disease and in the reduction of cardiovascular complications. We`ve attempted to summarize some data about the statins and interaction of antihypertensive drugs. Rosuvastatin is a medicine that provides an intensive reduction of low-density lipoproteins, does not require dose adjustment when applied in conjunction with antihypertensive drugs. The absence of inhibition and activation of rosuvastatin cytochrome P450 provides a low risk of negative interactions in the clinical situations of induced polypharmacy. Every clinician is to remember that it`s crucial to take into account some adverse reactions combining the statins with drugs of other pharmacological groups.

About the Authors

E. V. Luchinina
V.I.Razumovsky Saratov State Medical University of the Ministry of Health of the Russian Federation
Russian Federation


O. G. Kompaniets
Kuban State Medical University of the Ministry of Health of the Russian Federation
Russian Federation


N. V. Kizhvatova
Kuban State Medical University of the Ministry of Health of the Russian Federation
Russian Federation


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Review

For citations:


Luchinina E.V., Kompaniets O.G., Kizhvatova N.V. Interaction of antihypertensive drugs and rosuvastatin: focus on safety, efficiency and prospects. Systemic Hypertension. 2017;14(3):79-83. https://doi.org/10.26442/2075-082X_14.3.79-83

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ISSN 2075-082X (Print)
ISSN 2542-2189 (Online)