Using meldonium to improve adaptation of patients with hypertension and pre-diabetes to influence of heat

Abstract

Aim of the study was to evaluate the effect of meldonium the state of cardiovascular system and the quality of life of patients with arterial hypertension (AH) combined with pre-diabetes under the summer heat.Materials and methods. 45 hypertensive patients 51-76 years old with pre-diabetes. randomized to active management (M), which in addition to basic therapy received during the 3 summer months meldonium 1000 mg/day, and a control (C). Body mass index, office blood pressure, blood chemistry, HbA1c, pulse wave velocity (PWV), tissue glycation, visual analogue scale (VAS) were performed.Results. The trend to lower heart rate during the heat of the group M. In September, a trend increase in PWV (ΔPWV=1.7 m/s; p =0.056) in group C. Lipid and carbohydrate metabolism do not change. In both groups the trend to an increase in the level of sodium in the heat, in group M it remained until September. Increase sodium during heat greater in group M (Δ2.0 mmol/l vs 1,0 mmol/1); p =0.05. In group C, tendency to decrease VAS scores from 70 to 55 ( p =0.07) in group M trend to increase from 60 to 70 ( p =0.07), the differences between the groups were significant ( p =0.01). In group M trend continued in September.Conclusion. Meldonium can be used as an adaptogen in the period of summer heat in patients with hypertension in combination with pre-diabetes.