Specificity of the effect of double fractures of the rhythmogram on the daily variability of the sinus rhythm in patients with pulmonary and arterial hypertension

Introduction. In contrast to coronary heart disease (CHD), heart failure and a number of other diseases, in arterial and pulmonary hypertension, the deterioration of the functional state of the patient is often not accompanied by a decrease in the parameters of his sinus rhythm variability (SRV) for long periods of time. Moreover, an increase in age and an increase in blood pressure in patients with hypertension may lead not to a decrease, but to an increase in the parameters of daily SRV. It is noted that with hypertension on the sinus rhythm, the number of so-called double fractures of the rhythmogram (DFR) - sequences of RR intervals «short-long-short-long» - becomes greater, which can greatly affect the daily SRV. Aim. To study the specifics of the effect of DFR on daily SRV in arterial and pulmonary hypertension. Materials and methods. 300 Holter ECG records were analyzed, including 67 records of healthy persons, 20 records of CHD patients with CAG-confirmed vascular damage, 126 records of patients with arterial hypertension and 87 records of patients with idiopathic pulmonary hypertension. In the analysis of daily SRV, a modification of the SRV analysis method developed at the National Medical Research Center of Cardiology, taking into account the presence of DFR, was used. Results. It is shown that DFR reflects the processes of regulation of the sinus rhythm, which are affected differently by CHD and hypertension. In CHD, the frequency of DFR and its effect on the daily SRV significantly decreases (compared to the norm). With hypertension, the frequency of the appearance of DFR increases; there is a clear trend towards a decrease in SRV in comparison with the norm in the areas without DFR; in areas with DFR, this trend is less pronounced or absent, and at ages over 50 years, SRV increases. Conclusion. When studying the daily SRV of patients with arterial and idiopathic pulmonary hypertension, it is necessary to take into account the effect of DFR on the increase in SRV.

heart rate variability, coronary heart disease, arterial hypertension, pulmonary hypertension

1. Баевский Р.М., Берсенева А.П. Оценка адаптационных возможностей организма и риск развития заболеваний. М.: Медицина, 1997.

2. Баевский Р.М. Анализ вариабельности сердечного ритма при использовании различных электрокардиографических систем (методические рекомендации). Вестн. аритмологии. 2001; 24: 66-85.

3. Баевский Р.М., Кириллов О.И., Клецкин С.З. Математический анализ изменений сердечного ритма при стрессе. М.: Наука, 1984.

4. Heart rate variability. Standards of measurement, physiological interpretation, and clinical use. Task force of the European society of cardiology and the North American society of pacing and electrophysiology. Eur Heart J 1996; 17: 354-81.

5. Маколкин В.И., Зябрев Ф.Н. Может ли частота сердечных сокращений рассматриваться в качестве фактора риска сердечно-сосудистых заболеваний? Кардиоваск. терапия и профилактика. 2006; 5 (6): 5-9.

6. Wolf MM, Varigos GA, Hunt D, Sloman JG. Sinus arrhythmia in acute myocardial infarction. Med J Aust 1978; 2: 52-3.

7. Соболев А.В. Методы анализа вариабельности сердечного ритма на длительных промежутках времени. М.: Медпрактика, 2009.

8. Рябыкина Г.В., Соболев А.В. Холтеровское и бифункциональное мониторирование ЭКГ и артериального давления. Издание второе. М.: Медпрактика-М, 2016.

9. Соболев А.В. Анализ вариабельности сердечного (синусового) ритма. В кн.: Функциональная диагностика. Национальное руководство. Под ред. Н.Ф. Берестень, В.А. Сандрикова, С.И. Федоровой. М: ГЭОТАР-Медиа, 2019.

10. Медведев А.П., Гаврилушкин А.П., Маслюк А.П., и др. Анализ вариабельности ритма сердца у спортсменов. Учебное пособие. Н. Новгород: Изд-во Нижегородской мед. академии, 1999.

11. Соболев А.В., Рябыкина Г.В., Кожемякина Е.Ш. Новый метод анализа вариабельности синусового ритма на длительных промежутках времени, учитывающий наличие на ритмограмме двойных изломов. Современная функциональная диагностика. 2017; 1: 22-6.