The value of blood pressure variability in clinical practice. Opportunities of amlodipine in reducing blood pressure variability (based on the Russian program «VARIATIONS»)
Abstract
The article discusses the importance of different types of variability in blood pressure (BP) as an independent risk factor for stroke and myocardial infarction in patients with arterial hypertension. The results of the Russian observation program (1500 patients) on the impact of amlodipine show BP variability in real clinical practice. According to the results, amlodipine 5-10 mg after 2 weeks of treatment significantly reduces the variability of systolic and diastolic blood pressure in both sexes. His influence on the short-term variability in diastolic blood pressure is dose-dependent.
About the Authors
O. D. Ostroumova
ГБОУ ВПО МГМСУ им. А.И.Евдокимова Минздрава России; ГБОУ ВПО Первый МГМУ им. И.М.Сеченова Минздрава России
Russian Federation
Russian Federation
O. V. Bondarets
ГБОУ ВПО МГМСУ им. А.И.Евдокимова Минздрава России
Russian Federation
Russian Federation
T. F. Guseva
ГБОУ ВПО МГМСУ им. А.И.Евдокимова Минздрава России
Russian Federation
Russian Federation
References
1. Rothwell P.M, Howard S.C, Dolan E et al. Prognostic significance of visit - to - visit variability, maximum systolic blood pressure, and episodic hypertension. Lancet 2010; 375: 895-905.
2. Sever P.S, Dahlof B, Poulter N.R et al. Rationale, design, methods and baseline demography of participants of the Anglo- Scandinavian Cardiac Outcomes Trial. J Hypertens 2001; 6: 1139-47.
3. Dahlof B, Sever P.S, Poulter N.R et al. Prevention of cardiovascular events with an antihypertensive regimen of amlodipine adding perindopril as required versus atenolol adding bendroflumethiazide as required, in Anglo-Scandinavian Cardiac Outcomes Trial - Blood Pressure Lowering Arm (ASCOT-BPLA): a multicentral randomized controlled trial. Lancet 2005; 366: 895-906.
4. Webb A.J.S, Fischer U, Mehta Z, Rothwell P.M. Effects of antihypertensive - drug class on interindividual variation in BP and risk of stroke: a systematic review and meta - analysis. Lancet 2010; 375: 906-15.
5. Rothwell P.M, Webb A.J.S. Effect of Dose and Combination of Antihypertensives on Interindividual Blood Pressure Variability: A Systematic Review. Stroke 2011; 42: 2860-5.
6. Диагностика и лечение артериальной гипертензии. Российский рекомендации (четвертый пересмотр). Системные гипертензии. 2010; 3: 5-26.
Review
For citations:
Ostroumova O.D., Bondarets O.V., Guseva T.F. The value of blood pressure variability in clinical practice. Opportunities of amlodipine in reducing blood pressure variability (based on the Russian program «VARIATIONS»). Systemic Hypertension. 2014;11(1):11-16. (In Russ.)
Views:
154
Email this article 