Features of diagnostic search and choice of treatment strategy in patients with chronic thromboembolic pulmonary hypertension associated with systemic lupus erythematosus and antiphospholipid syndrome: case report
A. V. Ostraukh,
A. V. Zorin,
T. N. Veselova,
N. M. Danilov,
T. V. Martynyuk,
P. A. Sholkina,
T. M. Reshetnyak https://doi.org/10.38109/2075-082X-2025-3-19-24
Abstract
Chronic thromboembolic pulmonary hypertension (CTEPH) is a life-threatening form of pulmonary hypertension, caused by obstruction of the large and/or medium pulmonary arteries by organized thrombi. Currently, a multimodal approach, including surgical and endovascular treatment, using modern specific drugs has improved treatment results. This clinical case demonstrates the successful treatment with triple PAH-specific therapy and balloon angioplasty of the pulmonary arteries in the patient with severe CTEPH associated with systemic lupus erythematosus and antiphospholipid syndrome.
About the Authors
A. V. Ostraukh
E.I.Chazov National Medical Research Centre of Cardiology
Russian Federation
Russian Federation
Anastasia V. Ostraukh, resident of Department of pulmonary hypertension and heart disease, A.L.Myasnikov Scientific research institute of clinical cardiology
15A Academician Chazova str., Moscow
A. V. Zorin
E.I.Chazov National Medical Research Centre of Cardiology
Russian Federation
Russian Federation
Andrey V. Zorin, Cand. Sci. (Med.), Research Associate of Department of pulmonary hypertension and heart disease, A.L.Myasnikov Scientific research institute of clinical cardiology
15A Academician Chazova str., Moscow
T. N. Veselova
E.I.Chazov National Medical Research Centre of Cardiology
Russian Federation
Russian Federation
Tatiana N. Veselova, Dr. Sci. (Med.), Leading Research of Tomography Department, A.L. Myasnikov Scientific research institute of clinical cardiology
15A Academician Chazova str., Moscow
N. M. Danilov
E.I.Chazov National Medical Research Centre of Cardiology
Russian Federation
Russian Federation
Nikolay M. Danilov, Dr. Sci. (Med.), Leading Research of Hypertension Department, A.L. Myasnikov Scientific research institute of clinical cardiology
15A Academician Chazova str., Moscow
T. V. Martynyuk
E.I.Chazov National Medical Research Centre of Cardiology;
Pirogov Russian National Research Medical University
Russian Federation
Russian Federation
Tamila V. Martynyuk, Dr. Sci. (Med.), Head of Department of pulmonary hypertension and heart disease, A.L.Myasnikov Scientific research institute of clinical cardiology, Professor, Department of Cardiology, Faculty of Continuing Professional Education
15A Academician Chazova str., Moscow
1 Ostrovitianov str., Moscow 117997
P. A. Sholkina
V.A. Nasonova Research Institute of Rheumatology
Russian Federation
Russian Federation
Polina A. Sholkina, rheumatologist, Laboratory of thromboinflammation, Professor, Department of Rheumatology
34А Kashirskoe hwy., Moscow 115522
T. M. Reshetnyak
V.A. Nasonova Research Institute of Rheumatology;
Russian Medical Academy of Continuous Professional Education
Russian Federation
Russian Federation
Tatiana M. Reshetnyak, Dr. Sci. (Med.), Leading Research Associate of Laboratory of thromboinflammation, Professor, Department of Rheumatology
34А Kashirskoe hwy., Moscow 115522
2/1 Barrikadnaia str., Moscow 125993
References
1. Irina E. Chazova, Tamila V. Martynyuk, Anton A. Shmalts et al. Eurasian guidelines for the diagnosis and treatment of pulmonary hypertension (2023). Eurasian heart journal. February 2024;(1):6-85 (in Russ.) https://doi.org/10.38109/2225-1685-2023-1-6-85
2. Humbert M., Kovacs G., Hoeper M.M. et al. 2022 ESC/ERS guidelines for the diagnosis and treatment of pulmonary hypertension. Eur Respir J. 2022;43:3618-3731. https://doi.org/10.1093/eurheartj/ehac237
3. Reshetnyak T.M., Lisitsyna T.A., Cheldieva F.A. et al. Comparative assessment of sensitivity and specificity of three variants of classification criteria for systemic lupus erythematosus in a cohort of Russian patients. Terapevticheskii Arkhiv (Ter. Arkh.). 2023;95(5):410-417. (In Russ.) https://doi.org/10.26442/00403660.2023.05.202201
4. Martynyuk T.V. Chronic thromboembolic pulmonary hypertension: Guide for doctors/ Ed. Chazova I. E. – M: Medical Information Agency, 2023. P. 416 (In Russ.) ISBN 978-5-907098-61-9
5. Zhu R., Cheng Gang-Yi, Denas G., Pengo V. Antiphospholipid antibodies in chronic thromboembolic pulmonary hypertension. European Journal of Internal Medicine. 2023 May:111:1-4. https://doi.org/10.1016/j.ejim.2023.01.012
6. Irina E. Chazova, Tamila V. Martynyuk, Zarina S. Valieva et al. Eurasian Guidelines for the diagnosis and treatment of chronic thromboembolic pulmonary hypertension (2020). Eurasian heart journal. 2021; (1):6-43. (In Russ.) https://doi.org/10.38109/2225-1685-2021-1-6-43
Review
For citations:
Ostraukh A.V., Zorin A.V., Veselova T.N., Danilov N.M., Martynyuk T.V., Sholkina P.A., Reshetnyak T.M. Features of diagnostic search and choice of treatment strategy in patients with chronic thromboembolic pulmonary hypertension associated with systemic lupus erythematosus and antiphospholipid syndrome: case report. Systemic Hypertension. 2025;22(3):19-24. (In Russ.) https://doi.org/10.38109/2075-082X-2025-3-19-24
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